Ras Mapk | List of Frontiers open access articles

Original Research

Published on 21 Feb 2023

MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma

in Pediatric Oncology

Thomas F. Eleveld
Lindy Vernooij
Linda Schild
Bianca Koopmans
Lindy K. Alles
Marli E. Ebus
Rana Dandis
Harm van Tinteren
Huib N. Caron
Jan Koster

Frontiers in Oncology

doi 10.3389/fonc.2023.1130034

4,423 views
9 citations

Original Research

Published on 06 Dec 2024

Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11

in Cancer Molecular Targets and Therapeutics

Vid Mlakar
Ina Oehme
Laurence Lesne
Sara Najafi
Marc Ansari
Fabienne Gumy-Pause

Frontiers in Oncology

doi 10.3389/fonc.2024.1433256

3,297 views
2 citations

Brief Research Report

Published on 13 Aug 2021

Clinical and Cytometric Study of Immune Involvement in a Heterogeneous Cohort of Subjects With RASopathies and mTORopathies

in Pediatric Immunology

Erica Valencic
Prisca Da Lozzo
Gianluca Tornese
Elena Ghirigato
Francesco Facca
Elisa Piscianz
Flavio Faletra
Andrea Taddio
Alberto Tommasini
Andrea Magnolato

Frontiers in Pediatrics

doi 10.3389/fped.2021.703613

5,008 views
8 citations

Original Research

Published on 11 Sep 2025

Crhr1 and epinephrine utilize the central Ras-MAPK pathway in mediating the acute stress-related locomotor activity in zebrafish larvae

in Experimental Endocrinology

Enezi Khalid
Mathilakath M. Vijayan

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1650458

2,366 views

Original Research

Published on 15 Mar 2018

miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal

in Experimental Endocrinology

Ming Liu
Yongqing Wang
Huifen Lu
Hao Wang
Xiaoming Shi
Xuan Shao
Yu-xia Li
Yangyu Zhao
Yan-Ling Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2018.00100

5,486 views
38 citations

Mini Review

Published on 24 Dec 2021

Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer

in Thoracic Oncology

Juan Bautista Blaquier
Andrés Felipe Cardona
Gonzalo Recondo

Frontiers in Oncology

doi 10.3389/fonc.2021.787585

20,908 views
48 citations

Case Report

Published on 10 Aug 2023

Case Report: Sequential postzygotic HRAS mutation and gains of the paternal chromosome 11 carrying the mutated allele in a patient with epidermal nevus and rhabdomyosarcoma: evidence of a multiple-hit mechanism involving HRAS in oncogenic transformation

in Genetics of Common and Rare Diseases

Roberta Zuntini
Chiara Cattani
Lucia Pedace
Evelina Miele
Stefano Giuseppe Caraffi
Stefano Gardini
Elena Ficarelli
Simone Pizzi
Francesca Clementina Radio
Angelica Barone

Frontiers in Genetics

doi 10.3389/fgene.2023.1231434

4,118 views
1 citation

Review

Published on 04 Sep 2013

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

in T Cell Biology

Jesse E. Jun
Ignacio Rubio
Jeroen P. Roose

Frontiers in Immunology

doi 10.3389/fimmu.2013.00239

22,360 views
67 citations

Original Research

Published on 08 Sep 2022

Differences in severity of cardiovascular anomalies in children with Noonan syndrome based on the causative gene

in Genetics of Common and Rare Diseases

Nagham Shehade-Awwad
Yonatan Yeshayahu
Orit Pinhas-Hamiel
Uriel Katz

Frontiers in Pediatrics

doi 10.3389/fped.2022.946071

2,578 views
5 citations

Review

Published on 05 Feb 2020

Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model

in Cell Growth and Division

John E. La Marca
Helena E. Richardson

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2020.00042

21,808 views
139 citations

Case Report

Published on 25 Sep 2024

Case report: MEK inhibitor as treatment for multi-lineage mosaic KRAS G12D-associated epidermal nevus syndrome in a pediatric patient

in Neuro-Oncology and Neurosurgical Oncology

Margarita Dionysiou
Stavriani C. Makri
Shivani Ahlawat
Melike Guryildirim
Kristin W. Barañano
Mari L. Groves
Pedram Argani
Christine A. Pratilas

Frontiers in Neurology

doi 10.3389/fneur.2024.1466946

4,458 views
6 citations

Original Research

Published on 31 Jul 2023

Lipid profile in Noonan syndrome and related disorders: trend by age, sex and genotype

in Pediatric Endocrinology

Federica Tamburrino
Laura Mazzanti
Emanuela Scarano
Dino Gibertoni
Maria Sirolli
Maximiliano Zioutas
Concetta Schiavariello
Annamaria Perri
Alessio Mantovani
Cesare Rossi

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1209339

3,064 views
5 citations

Articles

MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma

Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11

Clinical and Cytometric Study of Immune Involvement in a Heterogeneous Cohort of Subjects With RASopathies and mTORopathies

Crhr1 and epinephrine utilize the central Ras-MAPK pathway in mediating the acute stress-related locomotor activity in zebrafish larvae

miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal

Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer

Case Report: Sequential postzygotic HRAS mutation and gains of the paternal chromosome 11 carrying the mutated allele in a patient with epidermal nevus and rhabdomyosarcoma: evidence of a multiple-hit mechanism involving HRAS in oncogenic transformation

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

Differences in severity of cardiovascular anomalies in children with Noonan syndrome based on the causative gene

Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model

Case report: MEK inhibitor as treatment for multi-lineage mosaic KRAS G12D-associated epidermal nevus syndrome in a pediatric patient

Lipid profile in Noonan syndrome and related disorders: trend by age, sex and genotype