Rat Oa Model | List of Frontiers open access articles

Original Research

Published on 15 Jul 2022

An Inducible Nitric Oxide Synthase Dimerization Inhibitor Prevents the Progression of Osteoarthritis

in Inflammation Pharmacology

Shang Xian Bo
Wang Yan Jie
Cai De Chao
Ma Sai
Wang Zhe
Zhu Ya Kun
Guo Hui Hui
Wang Chen
Ma Xiao
Hu Zhong Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2022.861183

3,824 views
8 citations

Original Research

Published on 17 Aug 2018

Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways

in Ethnopharmacology

Yao-Xin Gao
Hao-Heng Yu
Chuan He
Ming Li
Dan-Dan Guo
Jun-Jiang Lian
Hai-Jie Yang
Mian Wang
Lei Wang
Zhi-Wei Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00910

6,028 views
9 citations

Original Research

Published on 11 Aug 2025

The Eucommia ulmoides - Achyranthes bidentata pair and their active monomers exert synergistic therapeutic potential for osteoarthritis through the PI3K-AKT pathway

in Experimental Pharmacology and Drug Discovery

Chun Chen
Lei Lv
Yueying Huang
Fangyuan Xie
Mingzhu Gao
Sailiang Zeng
Zijun Wang
Xue Jiang
Yangyang Zhan
Leilei Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571884

2,666 views
1 citation

Original Research

Published on 15 Oct 2025

Combined multi-omics approach to identify the key metabolites, key microorganisms and biomarkers correlated with the neutrophil extracellular traps-associated gene TIMP1 in osteoarthritis

in Integrative and Regenerative Pharmacology

Yaoyu Xiang
Jizheng Li
Xidan Hu
Xianguang Yang
Fei Sun
Jing Yang
Weiqing Ge
Tao Zhou
En Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665228

2,889 views
1 citation

Original Research

Published on 13 Feb 2026

Identification of potential biomarkers related to the Bitong mixture in osteoarthritis based on bioinformatics and network pharmacology, and exploration of the mechanism involved

in Molecular Innate Immunity

Ziwei Shen
Suming Li
Teng Li
Lining Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1739355

373 views

Original Research

Published on 09 Mar 2022

Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis

in Molecular and Cellular Pathology

Shuangshuo Jia
Yue Yang
Yishu Bai
Yingliang Wei
He Zhang
Yicheng Tian
Jiabao Liu
Lunhao Bai

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.797855

10,130 views
65 citations

Original Research

Published on 23 Nov 2018

Intra-Articular Injection of Fructus Ligustri Lucidi Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats

in Ethnopharmacology

Bo Yan
Li Zhou
Caiwei Wang
Rongrong Wang
Li Yan
Lingying Yu
Fucun Liu
Wenxi Du
Guangping Yu
Qiang Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01360

4,875 views
12 citations

Articles

An Inducible Nitric Oxide Synthase Dimerization Inhibitor Prevents the Progression of Osteoarthritis

Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways

The Eucommia ulmoides - Achyranthes bidentata pair and their active monomers exert synergistic therapeutic potential for osteoarthritis through the PI3K-AKT pathway

Combined multi-omics approach to identify the key metabolites, key microorganisms and biomarkers correlated with the neutrophil extracellular traps-associated gene TIMP1 in osteoarthritis

Identification of potential biomarkers related to the Bitong mixture in osteoarthritis based on bioinformatics and network pharmacology, and exploration of the mechanism involved

Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis

Intra-Articular Injection of Fructus Ligustri Lucidi Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats