Repeated Dose Toxicity | List of Frontiers open access articles

Original Research

Published on 10 Feb 2025

The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy

in Pharmacology of Anti-Cancer Drugs

Huihui Guo
Hongsheng Xie
Yuanyuan Huang
Junxiang Jia
Xiangfei Kong
Qingliang Yang
Shun Gai
Wenjun Li
Lu Bai
Lingli Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532104

5,239 views
1 citation

Original Research

Published on 22 Apr 2025

Repeated-dose toxicity and immunogenicity evaluation of a recombinant subunit COVID-19 vaccine (ZF2001) in rats

in Adaptive immunity in infection

Ruimin Sun
Lijuan Xia
Guangbiao She
Jinrong Li
Yiru Wang
Yunxiang Chen
Qian Yang
Siming Zhang
Fang Liu
Ying Chen

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1548787

3,420 views

Perspective

Published on 28 Jun 2022

Treating Thyroid Associated Ophthalmopathy in Pediatric Patients

in Pediatric Endocrinology

Tianyu Dong
Zhujun Fu
Xu Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2022.900204

5,094 views
3 citations

Original Research

Published on 23 Mar 2021

Development of a New Threshold of Toxicological Concern Database of Non-cancer Toxicity Endpoints for Industrial Chemicals

in Computational Toxicology and Informatics

Takashi Yamada
Masayuki Kurimoto
Akihiko Hirose
Chihae Yang
James F. Rathman

Frontiers in Toxicology

doi 10.3389/ftox.2021.626543

7,047 views
8 citations

Original Research

Published on 22 Jul 2022

RAID: Regression Analysis–Based Inductive DNA Microarray for Precise Read-Across

in Predictive Toxicology

Yuto Amano
Masayuki Yamane
Hiroshi Honda

Frontiers in Pharmacology

doi 10.3389/fphar.2022.879907

4,428 views
1 citation

Original Research

Published on 20 Nov 2025

Evaluation of long-term safety profile of an EU-GMP certified Cannabis sativa L. strain in a naturally aging preclinical model

in Ethnopharmacology

Gabriela-Dumitrita Stanciu
Ivona Costachescu
Daniela-Carmen Ababei
Andrei Szilagyi
Raluca-Maria Gogu
Vlad-Constantin Craciun
Andrei-Daniel Timofte
Irina-Draga Caruntu
Cristina-Elena Dobre
Bogdan-Ionel Tamba

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1716366

1,147 views

Original Research

Published on 11 Apr 2024

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

in Regulatory Toxicology

Todd Bourcier
Timothy McGovern
Tania Cavaliero
Geoffrey Ebere
Akiyoshi Nishikawa
Jihei Nishimura
Kumiko Ogawa
Markku Pasanen
Alisa Vespa
Jan Willem Van der Laan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1353783

7,980 views
9 citations

Articles

The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy

Repeated-dose toxicity and immunogenicity evaluation of a recombinant subunit COVID-19 vaccine (ZF2001) in rats

Treating Thyroid Associated Ophthalmopathy in Pediatric Patients

Development of a New Threshold of Toxicological Concern Database of Non-cancer Toxicity Endpoints for Industrial Chemicals

RAID: Regression Analysis–Based Inductive DNA Microarray for Precise Read-Across

Evaluation of long-term safety profile of an EU-GMP certified Cannabis sativa L. strain in a naturally aging preclinical model

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup