Time Dependent Inhibition | List of Frontiers open access articles

Original Research

Published on 12 Feb 2025

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

in Drug Metabolism and Transport

Sadegh Faramarzi
Arianna Bassan
Kevin P. Cross
Xinning Yang
Glenn J. Myatt
Donna A. Volpe
Lidiya Stavitskaya

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451164

4,762 views
4 citations

Original Research

Published on 03 Dec 2024

The study of halogen effect on the reactivity of the serine-targeting covalent warheads

in Medicinal and Pharmaceutical Chemistry

Conghao Gai
Ya Zhang
Shihao Zhang
Xueyan Hu
Yun-Qing Song
Xiaoyu Zhuang
Xiaoyun Chai
Yan Zou
Guang-Bo Ge
Qingjie Zhao

Frontiers in Chemistry

doi 10.3389/fchem.2024.1504453

2,940 views
4 citations

Case Report

Published on 17 Jul 2017

Fatal Statin-Induced Rhabdomyolysis by Possible Interaction with Palbociclib

in Women's Cancer

Kellie Lynn Nelson
David Stenehjem
Meghan Driscoll
Glynn Weldon Gilcrease

Frontiers in Oncology

doi 10.3389/fonc.2017.00150

10,150 views
18 citations

Original Research

Published on 11 May 2022

Inhibition of Bacterial Neuraminidase and Biofilm Formation by Ugonins Isolated From Helminthostachys Zeylanica (L.) Hook

in Ethnopharmacology

Abdul Bari Shah
Aizhamal Baiseitova
Jeong Ho Kim
Yong Hyun Lee
Ki Hun Park

Frontiers in Pharmacology

doi 10.3389/fphar.2022.890649

4,410 views
16 citations

Original Research

Published on 15 Feb 2023

Inhibitory effect of Selaginella doederleinii hieron on human cytochrome P450

in Drug Metabolism and Transport

Fei Lin
Xinhua Lin
Xuewen Wang
Guanghui Mei
Bing Chen
Hong Yao
Lingyi Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1108867

4,699 views
5 citations

Original Research

Published on 17 Mar 2021

Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization

in Obstetric and Pediatric Pharmacology

Yahui Zhang
Sixuan Zhao
Chuhui Wang
Pengxiang Zhou
Suodi Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2021.636097

7,363 views
14 citations

Original Research

Published on 28 Feb 2020

Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding

in Molecular Recognition

Sara Hernando-Amado
Manuel Alcalde-Rico
Teresa Gil-Gil
José R. Valverde
José L. Martínez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.00025

8,153 views
78 citations

Original Research

Published on 18 Dec 2013

Concentration dependent effect of calcium on brain mitochondrial bioenergetics and oxidative stress parameters

Jignesh D. Pandya
Vidya N. Nukala
Patrick G Sullivan

Frontiers in Neuroenergetics

doi 10.3389/fnene.2013.00010

114,377 views
112 citations

Original Research

Published on 10 Nov 2021

Gene Expression in Amnion-Derived Cells Cultured on Recombinant Laminin 332—A Preliminary Study

in Gene and Cell Therapy

Katarzyna Skowron-Kandzia
Marcin Tomsia
Halina Koryciak-Komarska
Danuta Plewka
Patrycja Wieczorek
Piotr Czekaj

Frontiers in Medicine

doi 10.3389/fmed.2021.719899

3,207 views
1 citation

Original Research

Published on 22 Nov 2019

Nematode-Associated Bacteria: Production of Antimicrobial Agent as a Presumptive Nominee for Curing Endodontic Infections Caused by Enterococcus faecalis

in Antimicrobials, Resistance and Chemotherapy

Hicran Donmez Ozkan
Harun Cimen
Derya Ulug
Sebastian Wenski
Senem Yigit Ozer
Murat Telli
Neriman Aydin
Helge B. Bode
Selcuk Hazir

Frontiers in Microbiology

doi 10.3389/fmicb.2019.02672

10,333 views
32 citations

Original Research

Published on 18 Sep 2023

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes

in Drug Metabolism and Transport

Yunyun Zhan
Anzhou Wang
Yige Yu
Jie Chen
Xinhao Xu
Jingjing Nie
Jingjing Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1199548

6,119 views
7 citations

Original Research

Published on 30 Apr 2020

In Vitro Assessment of the Interaction Potential of Ocimum basilicum (L.) Extracts on CYP2B6, 3A4, and Rifampicin Metabolism

in Ethnopharmacology

Saneesh Kumar
Patrick J. Bouic
Bernd Rosenkranz

Frontiers in Pharmacology

doi 10.3389/fphar.2020.00517

21,840 views
16 citations

Articles

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes

The study of halogen effect on the reactivity of the serine-targeting covalent warheads

Fatal Statin-Induced Rhabdomyolysis by Possible Interaction with Palbociclib

Inhibition of Bacterial Neuraminidase and Biofilm Formation by Ugonins Isolated From Helminthostachys Zeylanica (L.) Hook

Inhibitory effect of Selaginella doederleinii hieron on human cytochrome P450

Application of a Physiologically Based Pharmacokinetic Model to Characterize Time-dependent Metabolism of Voriconazole in Children and Support Dose Optimization

Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding

Concentration dependent effect of calcium on brain mitochondrial bioenergetics and oxidative stress parameters

Gene Expression in Amnion-Derived Cells Cultured on Recombinant Laminin 332—A Preliminary Study

Nematode-Associated Bacteria: Production of Antimicrobial Agent as a Presumptive Nominee for Curing Endodontic Infections Caused by Enterococcus faecalis

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes

In Vitro Assessment of the Interaction Potential of Ocimum basilicum (L.) Extracts on CYP2B6, 3A4, and Rifampicin Metabolism