Top Down Effect | List of Frontiers open access articles

Review

Published on 04 Mar 2026

Mitochondrial metabolism in cancer stem cells (CSCs): molecular and diagnostic implications

in Molecular Diagnostics and Therapeutics

Charan PSVV
Sona Sunil
Nandana Thuyyath
Rekha Rani Kokkanti
Kousalya Lavudi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1741800

300 views

Original Research

Published on 04 Mar 2026

Fractional CO2 laser therapy for genitourinary syndrome of menopause: symptom-specific trajectories, exposure–outcome associations, and ultrasonographic changes in vulvar soft tissue in a cohort of 826 women

in Menopause

Mariko Hatta
Hiroaki Ohta
Kuniaki Ota
Remi Yoshikata
Stefano Salvatore

Frontiers in Reproductive Health

doi 10.3389/frph.2026.1776174

Review

Published on 04 Mar 2026

The brain-gut-muscle axis: a mechanism for exercise-mediated protection in brain aging

in Neurocognitive Aging and Behavior

Wenyu Sun
WanHong Wang
Yu Zhang
Huifen Liu
Linlin Li
Yang Zhang
Bin Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1761832

Original Research

Published on 04 Mar 2026

Association of the triglyceride-glucose index with carotid intima-media thickness in type 2 diabetes: effect modification by age and albuminuria—a retrospective cross-sectional study

in Cardiovascular Metabolism

Yanmei Lin
Kang Du
Jianqing Tian

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1711633

131 views

Original Research

Published on 04 Mar 2026

Diagnostic utility of high-resolution magnetic resonance vessel wall imaging for identifying culprit plaques in intracranial atherosclerotic disease

in Applied Neuroimaging

Qing Li
Kunheng Fan
Feifeng Liu
Shuguang Chu
Jianhua Zhang
Changlong Hou

Frontiers in Neurology

doi 10.3389/fneur.2026.1677672

Original Research

Published on 04 Mar 2026

Integrated transcriptomic, protein, and MicroRNA profiling reveals a conserved pyroptosis-related molecular signature across breast cancer subtypes

in Molecular Diagnostics and Therapeutics

Agata Panfil
Tomasz Sirek
Agata Sirek
Nikola Zmarzły
Michalina Wróbel
Zbigniew Wróbel
Kacper Boroń
Dariusz Boroń
Piotr Ossowski
Martyna Stefaniak

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1759944

234 views

Case Report

Published on 04 Mar 2026

Intraoperative vascular ligation uncovers the role of tumor vasculature in Doege-Potter syndrome: a case report

in Thoracic Oncology

Lin Du
Kai Wei
Na Li
Yajing Sun
Dongmei Liu
Geng Xu
Tao Yang
Xiuqiang Zhang

Frontiers in Oncology

doi 10.3389/fonc.2026.1701711

Original Research

Published on 04 Mar 2026

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

in Comparative Immunology

Jun Jet Hen
Ariel Isaacs
Benjamin Liang
Tony Schountz
Keith Chappell
Paul R. Young
Naphak Modhiran
Daniel Watterson

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743193

180 views

Original Research

Published on 04 Mar 2026

The role of L3 skeletal muscle index in the diagnosis and prognosis prediction of sarcopenia and malnutrition in cancer patients

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Zhuo Chen
Deduo Xu
Xingyun Hou
Zhipeng Wang
Jinping Xiong
Mingying Geng
Jing Xu
Yanyan Gu

Frontiers in Oncology

doi 10.3389/fonc.2026.1759925

Original Research

Published on 04 Mar 2026

Dietary modulation of intestinal integrity and functionality in weaned piglets using short-chain fructooligosaccharides, essential oils and sodium humate

in Animal Nutrition and Metabolism

J. M. Decundo
J. Mozo
D. S. Pérez Gaudio
G. Martínez
S. N. Dieguez
C. P. Bianchi
V. R. Eguía
M. L. Maté
J. P. Lirón
F. A. Amanto

Frontiers in Veterinary Science

doi 10.3389/fvets.2026.1771820

Original Research

Published on 04 Mar 2026

Antibody elution methods for multiplex immunofluorescence of Alzheimer's disease pathology in human post-mortem brain tissue

in Dementia and Neurodegenerative Diseases

Dhiraj Maskey
Hoang-Tuong Nguyen-Hao
Caine C. Smith
Mario Novelli
Julia Stevens
Greg T. Sutherland

Frontiers in Neurology

doi 10.3389/fneur.2026.1760600

133 views

Original Research

Published on 04 Mar 2026

A real-world comparison study of the efficacy of dual-target first-line rescue treatment of human epidermal growth factor receptor 2 positive advanced breast cancer: trastuzumab combined with pertuzumab versus trastuzumab combined with pyrotinib

in Breast Cancer

Liang Zhang
Chao Li
Shubin Song
Fukai Wang
Tingting Ding
Zhengrui Liu
Yuqin Jin
Zhiyong Yu

Frontiers in Oncology

doi 10.3389/fonc.2026.1720851

Original Research

Published on 04 Mar 2026

Predicting cardiovascular events in hemodialysis patients based on the fusion of physicochemical indicators and tongue images: a prospective and multicenter study

in Computational Physiology and Medicine

Kun Zou
Fan Xiao
Shuang Cheng
Qingxiang Wang
Xiaohua He
Jin Wang
Lijuan Dong
Kun Bao
Wu Zhou
Daixin Zhao

Frontiers in Physiology

doi 10.3389/fphys.2026.1782190

Original Research

Published on 04 Mar 2026

Total body water to lean body mass ratio predicts mortality in patients with chronic heart failure: a prospective, observational study

in Clinical Nutrition

Linfeng Xie
Bryan Richard Sasmita
Yuhe Zhao
Jing Chen
Yuanzhu Li
Suxin Luo
Bi Huang

Frontiers in Nutrition

doi 10.3389/fnut.2026.1762912

Original Research

Published on 04 Mar 2026

Dual-level weighted cross-entropy loss function and multi-object region segmentation network evaluation for dynamic knee joint X-ray radiography based on a novel scoring criterion

in Medical Imaging and Nuclear Medicine

Shiming Wang
Tianqi Wu
Weiqing Huang
Jinglong Du
Ziran Chen
Zhibo Xiao
Qi Gao
Yun Liu
Yingying Chen
Peng Guo

Frontiers in Medicine

doi 10.3389/fmed.2026.1768134

Brief Research Report

Published on 04 Mar 2026

Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer after prior vascular endothelial growth factor receptor-targeted therapy (COSMIC-311): outcomes by BRAF status

in Head and Neck Cancer

Marcia S. Brose
Bhumsuk Keam
Jolanta Krajewska
Ana O. Hoff
Fernanda Vaisman
Chia-Chi Lin
Erika Hitre
Daniel W. Bowles
Bruce Robinson
Steven I. Sherman

Frontiers in Oncology

doi 10.3389/fonc.2026.1748566

260 views

Articles

Mitochondrial metabolism in cancer stem cells (CSCs): molecular and diagnostic implications

Fractional CO2 laser therapy for genitourinary syndrome of menopause: symptom-specific trajectories, exposure–outcome associations, and ultrasonographic changes in vulvar soft tissue in a cohort of 826 women

The brain-gut-muscle axis: a mechanism for exercise-mediated protection in brain aging

Association of the triglyceride-glucose index with carotid intima-media thickness in type 2 diabetes: effect modification by age and albuminuria—a retrospective cross-sectional study

Diagnostic utility of high-resolution magnetic resonance vessel wall imaging for identifying culprit plaques in intracranial atherosclerotic disease

Integrated transcriptomic, protein, and MicroRNA profiling reveals a conserved pyroptosis-related molecular signature across breast cancer subtypes

Intraoperative vascular ligation uncovers the role of tumor vasculature in Doege-Potter syndrome: a case report

Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)

The role of L3 skeletal muscle index in the diagnosis and prognosis prediction of sarcopenia and malnutrition in cancer patients

Dietary modulation of intestinal integrity and functionality in weaned piglets using short-chain fructooligosaccharides, essential oils and sodium humate

Antibody elution methods for multiplex immunofluorescence of Alzheimer's disease pathology in human post-mortem brain tissue

A real-world comparison study of the efficacy of dual-target first-line rescue treatment of human epidermal growth factor receptor 2 positive advanced breast cancer: trastuzumab combined with pertuzumab versus trastuzumab combined with pyrotinib

Predicting cardiovascular events in hemodialysis patients based on the fusion of physicochemical indicators and tongue images: a prospective and multicenter study

Total body water to lean body mass ratio predicts mortality in patients with chronic heart failure: a prospective, observational study

Dual-level weighted cross-entropy loss function and multi-object region segmentation network evaluation for dynamic knee joint X-ray radiography based on a novel scoring criterion

Cabozantinib versus placebo in patients with radioiodine-refractory differentiated thyroid cancer after prior vascular endothelial growth factor receptor-targeted therapy (COSMIC-311): outcomes by BRAF status