Trypanothione | List of Frontiers open access articles

Original Research

Published on 14 May 2025

Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis

in Theoretical Modeling, Structure Prediction & Design

Cécile Exertier
Lorenzo Antonelli
Vittorio Brufani
Gianni Colotti
Andrea Ilari
Annarita Fiorillo

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1605579

2,355 views

Original Research

Published on 04 Feb 2019

Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach

in Parasite and Host

Anurag Kumar
Nutan Chauhan
Shailza Singh

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2019.00015

5,781 views
16 citations

Original Research

Published on 25 Mar 2021

Epigallocathechin-O-3-Gallate Inhibits Trypanothione Reductase of Leishmania infantum, Causing Alterations in Redox Balance and Leading to Parasite Death

in Parasite and Host

Job D. F. Inacio
Myslene S. Fonseca
Gabriel Limaverde-Sousa
Ana M. Tomas
Helena Castro
Elmo E. Almeida-Amaral

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2021.640561

4,684 views
15 citations

Original Research

Published on 06 Dec 2022

Graphene quantum dots induce cascadic apoptosis via interaction with proteins associated with anti-oxidation after endocytosis by Trypanosoma brucei

in Parasite Immunology

Yiwei Xie
Hongrui Liang
Ning Jiang
Dingyuan Liu
Naiwen Zhang
Qilong Li
Kai Zhang
Xiaoyu Sang
Ying Feng
Ran Chen

Frontiers in Immunology

doi 10.3389/fimmu.2022.1022050

3,866 views
4 citations

Original Research

Published on 04 Jul 2022

Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

in Structural Biology

Annarita Fiorillo
Gianni Colotti
Cécile Exertier
Anastasia Liuzzi
Francesca Seghetti
Alessandra Salerno
Jessica Caciolla
Andrea Ilari

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.900882

5,042 views
12 citations

Mini Review

Accepted on 12 Feb 2026

Metal-based compounds and Chagas Disease treatment: current knowledge and therapeutic perspectives

in Anti-Infective Agents

Vitor Klipel da Silva Bertolini
Jennyfer Castro
Josielle Vieira Fontes
Camilla Abbehausen
Fernanda Ramos Gadelha

Frontiers in Drug Discovery

Original Research

Published on 06 Mar 2024

Anti-leishmanial activity of Eleutherine plicata Herb. and predictions of isoeleutherin and its analogues

in Organic Chemistry

Kelly Cristina Oliveira de Albuquerque
Andreza do Socorro Silva da Veiga
Fernando Tobias Silveira
Marliane Batista Campos
Ana Paula Lima da Costa
Ananda Karolyne Martins Brito
Paulo Ricardo de Souza Melo
Sandro Percario
Fábio Alberto de Molfetta
Maria Fâni Dolabela

Frontiers in Chemistry

doi 10.3389/fchem.2024.1341172

3,655 views
2 citations

Original Research

Published on 25 May 2020

Leishmanicidal Potential of Hardwickiic Acid Isolated From Croton sylvaticus

in Experimental Pharmacology and Drug Discovery

Justice Afrifa Crentsil
Lauve Rachel Tchokouaha Yamthe
Barbara Zenabu Anibea
Emmanuel Broni
Samuel Kojo Kwofie
John Kweku Amissah Tetteh
Dorcas Osei-Safo

Frontiers in Pharmacology

doi 10.3389/fphar.2020.00753

7,458 views
28 citations

Articles

Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis

Understanding the Cross-Talk of Redox Metabolism and Fe-S Cluster Biogenesis in Leishmania Through Systems Biology Approach

Epigallocathechin-O-3-Gallate Inhibits Trypanothione Reductase of Leishmania infantum, Causing Alterations in Redox Balance and Leading to Parasite Death

Graphene quantum dots induce cascadic apoptosis via interaction with proteins associated with anti-oxidation after endocytosis by Trypanosoma brucei

Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

Metal-based compounds and Chagas Disease treatment: current knowledge and therapeutic perspectives

Anti-leishmanial activity of Eleutherine plicata Herb. and predictions of isoeleutherin and its analogues

Leishmanicidal Potential of Hardwickiic Acid Isolated From Croton sylvaticus