Genome Editing

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Genome Editing

Genome editing explores the tools and techniques that enable targeted modifications to DNA. Our Research Topics span CRISPR, base editing, gene drives, and epigenetic editing, advancing both foundational science and therapeutic innovation. By connecting experts across disciplines, we aim to accelerate breakthroughs that shape the future of medicine, agriculture, and biotechnology.

The following Research Topics are led by experts in their field and contribute to the scientific understanding of surgery. These Research Topics are published in the peer-reviewed journal Frontiers in Genome Editing, as open access articles.

Research Topics

Frontiers' Research Topics are peer-reviewed article collections around cutting-edge research themes.
Learn more about how Research topics work.

Gene Editing: New Frontiers to Fight Genetic Diseases

The goal of genome editing technology is to develop strategies for the correction of those mutations that are responsible of a plethora of genetic diseases that collectively affect hundreds of millions of people.

Base and Prime Editing for Correction of Cancer-Associated Mutations

This Research Topic aims to gather and highlight recent progress in the development and application of base and prime editing tools for the targeted correction of somatic mutations implicated in various cancers.

Epigenome Editing to Overcome Hormone Therapy Resistance in Breast Cancer

This Research Topic aims to bring together cutting-edge original research, reviews, and perspectives focused on epigenome editing as a strategy to address hormone therapy resistance in breast cancer.

Next-Generation CRISPR Systems: Expanding the Genome Editing Toolbox

This Research Topic invites exploration of the molecular mechanisms, engineering advancements, and innovative applications of next-generation CRISPR tools. Key areas of interest include the discovery and characterization of...

Engineering the Tumor Microenvironment in Pancreatic Cancer via Genome Editing

This Research Topic aims to highlight cutting-edge research and reviews that leverage genome editing technologies to investigate or therapeutically target the TME in pancreatic cancer.

Genome-Engineered CAR-T and CAR-NK Cell Therapies for Hematological Malignancies

This Research Topic aims to bring together original research articles, comprehensive reviews, perspectives, and clinical trial reports addressing recent advancements in genome-edited CAR-T and CAR-NK cell therapies for the treatment of leukemias...

3D rendering of Tumor Microenvironment

Multiplex Genome Editing to Overcome Tumor Immune Evasion

This Research Topic aims to showcase the latest developments and applications in multiplex genome editing designed to overcome tumor immune evasion. We welcome original research articles, reviews, mini-reviews, methods papers, and perspectives across...

DNA molecules, structure of the genetic code, 3d rendering,conceptual image.

Gene Editing for Enhanced Plant Reproduction Systems: Shaping a Resilient Future

This research topic aims to address the fundamental problem of improving plant reproductive systems to meet global challenges. The reproductive process leading to seed formation in flowering plants is complex, involving diverse signaling...

In Ultra Modern Electronic Manufacturing Factory Design Engineer in Sterile Coverall Holds Microchip with symbols in futuristic holography. artificial intelligence, future of robots.

Computational Methods and AI in Genome Editing

This Research Topic aims to present developments and innovations in bioinformatic software and computational methods to analyze CRISPR-based datasets. In addition, it aims to explore the application of artificial intelligence (AI) in genome editing...

Gene Editing: New Frontiers to Fight Genetic Diseases

The goal of genome editing technology is to develop strategies for the correction of those mutations that are responsible of a plethora of genetic diseases that collectively affect hundreds of millions of people.

Base and Prime Editing for Correction of Cancer-Associated Mutations

This Research Topic aims to gather and highlight recent progress in the development and application of base and prime editing tools for the targeted correction of somatic mutations implicated in various cancers.

Epigenome Editing to Overcome Hormone Therapy Resistance in Breast Cancer

This Research Topic aims to bring together cutting-edge original research, reviews, and perspectives focused on epigenome editing as a strategy to address hormone therapy resistance in breast cancer.

Next-Generation CRISPR Systems: Expanding the Genome Editing Toolbox

This Research Topic invites exploration of the molecular mechanisms, engineering advancements, and innovative applications of next-generation CRISPR tools. Key areas of interest include the discovery and characterization of...

Engineering the Tumor Microenvironment in Pancreatic Cancer via Genome Editing

This Research Topic aims to highlight cutting-edge research and reviews that leverage genome editing technologies to investigate or therapeutically target the TME in pancreatic cancer.

Genome-Engineered CAR-T and CAR-NK Cell Therapies for Hematological Malignancies

This Research Topic aims to bring together original research articles, comprehensive reviews, perspectives, and clinical trial reports addressing recent advancements in genome-edited CAR-T and CAR-NK cell therapies for the treatment of leukemias...

3D rendering of Tumor Microenvironment

Multiplex Genome Editing to Overcome Tumor Immune Evasion

This Research Topic aims to showcase the latest developments and applications in multiplex genome editing designed to overcome tumor immune evasion. We welcome original research articles, reviews, mini-reviews, methods papers, and perspectives across...

DNA molecules, structure of the genetic code, 3d rendering,conceptual image.

Gene Editing for Enhanced Plant Reproduction Systems: Shaping a Resilient Future

This research topic aims to address the fundamental problem of improving plant reproductive systems to meet global challenges. The reproductive process leading to seed formation in flowering plants is complex, involving diverse signaling...

In Ultra Modern Electronic Manufacturing Factory Design Engineer in Sterile Coverall Holds Microchip with symbols in futuristic holography. artificial intelligence, future of robots.

Computational Methods and AI in Genome Editing

This Research Topic aims to present developments and innovations in bioinformatic software and computational methods to analyze CRISPR-based datasets. In addition, it aims to explore the application of artificial intelligence (AI) in genome editing...