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Frontiers in Neurology


Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neurol. | doi: 10.3389/fneur.2018.01005

Clinical and radiological markers of extra-motor deficits in amyotrophic lateral sclerosis

 FOTEINI CHRISTIDI1*,  Efstratios Karavasilis2, Michail Rentzos1, Nikolaos Kelekis2,  Ioannis Evdokimidis1 and  Peter Bede3
  • 1Aeginition Hospital, National and Kapodistrian University of Athens, Greece
  • 2University General Hospital Attikon, Greece
  • 3Quantitative Neuroimaging Group, Trinity Biomedical Sciences Institute, Ireland

Amyotrophic lateral sclerosis (ALS) is now universally recognised as a complex multisystem disorder with considerable extra-motor involvement. The neuropsychological manifestations of frontotemporal, parietal and basal ganglia involvement in ALS have important implications for compliance with assistive devices, survival, participation in clinical trials, caregiver burden, and the management of individual care needs. Recent advances in neuroimaging have been instrumental in characterising the biological substrate of heterogeneous cognitive and behavioural deficits in ALS. In this review we discuss the clinical and radiological aspects of cognitive and behavioural impairment in ALS focusing on the recognition, assessment, and monitoring of these symptoms.

Keywords: Amyotrophic Lateral Sclerosis (ALS), extra-motor involvement, Cognition, behaviour, neuropsychological deficits, Neuroimaging

Received: 03 Oct 2018; Accepted: 06 Nov 2018.

Edited by:

Pierre-francois Pradat, Hôpitaux Universitaires Pitié Salpêtrière, France

Reviewed by:

Giorgia Querin, INSERM U1146 Laboratoire d'Imagerie Biomédicale, France
Christos Bakirtzis, Aristotle University of Thessaloniki, Greece  

Copyright: © 2018 CHRISTIDI, Karavasilis, Rentzos, Kelekis, Evdokimidis and Bede. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. FOTEINI CHRISTIDI, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece,