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CLINICAL TRIAL article

Front. Neurol.
Sec. Neurorehabilitation
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1364270
This article is part of the Research Topic Neurostimulation: Exploring Perceptual & Cognitive Enhancement View all 3 articles

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Provisionally accepted
Teris Cheung Teris Cheung 1,2*Benjamin K. Yee Benjamin K. Yee 1,2Bolton K. Chau Bolton K. Chau 1,2Joyce Yuen Ting Lam Joyce Yuen Ting Lam 1Tommy Kwan Hin Fong Tommy Kwan Hin Fong 1Herman Hay-ming Lo Herman Hay-ming Lo 1Tim M.H. Li Tim M.H. Li 3Albert M. Li Albert M. Li 3Lei SUN Lei SUN 1Roland Beisteiner Roland Beisteiner 4Pak Wing, Calvin Cheng Pak Wing, Calvin Cheng 5*
  • 1 Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR China
  • 2 Mental Health Research Centre, Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR China
  • 3 The Chinese University of Hong Kong, Shatin, Hong Kong Region, China
  • 4 Medical University of Vienna, Vienna, Vienna, Austria
  • 5 The University of Hong Kong, Pokfulam, Hong Kong, SAR China

The final, formatted version of the article will be published soon.

    Background: This is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong. Methods: This double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyse data. Results: The TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups. Conclusion: TPS is an effective and safe adjunct treatment for the clinical management of ADHD. Clinical Trial Registration: ClinicalTrials.gov, NCT05422274.

    Keywords: efficacy, Transcranial Pulse Stimulation, rct, ADHD, Neuromodulation, adolescents

    Received: 02 Jan 2024; Accepted: 17 Apr 2024.

    Copyright: © 2024 Cheung, Yee, Chau, Lam, Fong, Lo, Li, Li, SUN, Beisteiner and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Teris Cheung, Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR China
    Pak Wing, Calvin Cheng, The University of Hong Kong, Pokfulam, 999077, Hong Kong, SAR China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.