Wearing a KN95/FFP2 facemask has no measureable effect on functional activity in a challenging working memory n-back task Provisionally Accepted

Marie-Louise Montandon¹ Sven HALLER^2* Cristelle Rodriguez³ Francois R. HERRMANN⁴ Panteleimon Giannakopoulos¹

• ¹Hôpitaux universitaires de Genève (HUG), Switzerland
• ²CIMC Centre d'Imagerie Medicale Cornavin, Switzerland
• ³University Hospitals Geneva Medical Center, United States
• ⁴University Hospitals of Geneva, Switzerland

Wide use of facemasks is one of the many consequences of the COVID-19 pandemic. We used an established working memory n-back task in functional magnetic resonance imaging (fMRI) to explore whether wearing a KN95/FFP2 facemask affects overall performance and brain activation patterns. We provide here a prospective crossover design 3T fMRI study with/without wearing a tight FFP2/KN95 facemask, including 24 community-dwelling male healthy control participants (mean age ± SD = 37.6 ± 12.7 years) performing a 2-back task. Data analysis was performed using the FSL toolbox, performing both task-related and functional connectivity independent component analyses. Wearing an FFP2/KN95 facemask did not impact behavioral measures of the 2-back task (response time and number of errors). The 2-back task resulted in typical activations in working-memory related areas in both MASK and NOMASK conditions. There were no statistically significant differences in MASK versus NOMASK while performing the 2-back task in both task-related and functional connectivity fMRI analyses. In conclusion, the effect of wearing a tight FFP2/KN95 facemasks did not significantly affect working memory performance and brain activation patterns of functional connectivity.