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Original Research ARTICLE

Front. Neuroinform., 05 April 2019 | https://doi.org/10.3389/fninf.2019.00024

PManalyzer: A Software Facilitating the Study of Sensorimotor Control of Whole-Body Movements

  • 1Department of Sport Science, University of Innsbruck, Innsbruck, Austria
  • 2Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy
  • 3Department of Physical Therapy, University of Phayao, Mae Ka, Thailand

Motion analysis is used to study the functionality or dysfunctionality of the neuromuscular system, as human movements are the direct outcome of neuromuscular control. However, motion analysis often relies on measures that quantify simplified aspects of a motion, such as specific joint angles, despite the well-known complexity of segment interactions. In contrast, analyzing whole-body movement patterns may offer a new understanding of movement coordination and movement performance. Clinical research and sports technique evaluations suggest that principal component analysis (PCA) provides novel and valuable insights into control aspects of the neuromuscular system and how they relate to coordinative patterns. However, the implementation of PCA computations are time consuming, and require mathematical knowledge and programming skills, drastically limiting its application in current research. Therefore, the aim of this study is to present the Matlab software tool “PManalyzer” to facilitate and encourage the application of state-of-the-art PCA concepts in human movement science. The generalized PCA concepts implemented in the PManalyzer allow users to apply a variety of marker set independent PCA-variables on any kinematic data and to visualize the results with customizable plots. In addition, the extracted movement patterns can be explored with video options that may help testing hypotheses related to the interplay of segments. Furthermore, the software can be easily modified and adapted to any specific application.

Introduction

Sensorimotor control of movements is one of the most important functions of the nervous system. It involves detecting the physical state which the biomechanical system is in; processing this information to determine which changes to the system are desired or need to be opposed; and activating the motor system to generate the forces that produce the required changes to the system. From a biophysical viewpoint, the state of the biomechanical system is fully described, when the position and velocity of the body segments are known. Thus, full-body motion analysis offers an approach for studying the function of the nervous system by determining, on the one hand, the state of the system and thus the input to the various sensory systems, and, on the other hand, the accelerations of the body segments and thus the resultant output of the neuromuscular system.

However, multi-segment human movements allow many degrees of freedom DOF and typically allow a large variety of different movement strategies to successfully achieve a goal (Bernstein, 1967), i.e., human movements are mechanically complex. Therefore, conventional movement analyses often look into specific, pre-determined aspects of a motion. Such analyses often neglect important information about segment interactions; and the complex nature of these interactions makes a priori variable determination prone to false identification of important aspects. That is why other approaches quantify whole body kinematics (Honegger et al., 2013; Boström et al., 2018). Nevertheless, most of these approaches still rely on pre-defined aspects of specific movements such as angles, torques, or segment trajectories.

In the past two decades several principal component analysis (PCA) based approaches were developed for various applications in kinematic data analysis (Sadeghi et al., 1997; Troje, 2002; Daffertshofer et al., 2004; Wang et al., 2014), with the aim of determining relevant aspects of a motion in an unbiased and data driven way. One of these approaches identifies whole-body movement components (Troje, 2002; Daffertshofer et al., 2004), later called principal movements PMk (Federolf et al., 2012), thus reducing data complexity without neglecting segment interactions. In this framework, a PCA yields eigenvectors PCk, eigenvalues EVk and score time-series called principal positions PPk(t). Each PCk defines one type of movement or movement strategy that the respective PMk describes, while each EVk determines the amount of total variance in the data explained by the respective PMk. Furthermore, the scores PPk(t) determine the evolution of the respective PMk over time.

Among the first papers applying PCA in this sense were studies on walking patterns and gait forms (Troje, 2002; Daffertshofer et al., 2004; Verrel et al., 2009). In these studies, a separate PCA was conducted for each trial and the individual EV-spectra characterizing the amount of contribution of each individual postural strategy were compared. On the one hand, this approach allowed programming a motion synthesizer that displays gait forms according to different classifiers such as gender, weight, and emotional condition (Troje, 2002). On the other hand, it could be shown that gait regularity is not only affected by cognitive dual-tasking, but that different age groups display different changes in regularity (Verrel et al., 2009).

These results established PCA as a useful tool to analyze human movements. However, only EV-spectra describing the contribution of trial specific movement patterns could be compared, thus the comparison of movements between subjects or trials remained unsolved. Soon after, it was shown that one PCA could be conducted on several trials of various participants simultaneously, if the datasets were normalizing appropriately (Federolf P. et al., 2013). This approach enabled the comparison of the movement executions PPk(t) between trials. Furthermore, the relative contribution of each PMk to a trial's overall variance (corresponding to the EVk) was quantified with the variable rVARk computed on the PPk(t).

Amongst others, the rVARk and PPk(t) have provided new insights into the execution of sports techniques in alpine skiing, cross-country skiing, karate, dancing, cycling and race-walking (Donà et al., 2009; Moore et al., 2011; Masurelle et al., 2013; Federolf et al., 2014; Gløersen et al., 2017; Zago et al., 2017a). Moreover, related variables such as residual variances RVk or relative standard deviations rSTDk have been used to quantify the dimensionality of coordinative tasks such as juggling or balancing (Zago et al., 2017b; Haid and Federolf, 2018).

While the studies discussed so far applied the PCA method to compare movements, they have not calculated velocities or accelerations, and thus have not studied the control of movements. Only in 2016 it was suggested to differentiate the PPk-time series to obtain principal velocities PVk and principal accelerations PAk (Federolf, 2016). Since then, PAk and variables based on PAk have been used to study differences in movement control due to aging (Haid et al., 2018) or leg dominance/laterality (Promsri et al., 2018a). The PPk and PPk-variables were also applied in postural control research and linked to COP-time-series (Federolf, 2016), which are analyzed in a range of clinical applications that investigate impairments due to aging, overweight, back pain, concussion, multiple sclerosis, autism spectrum disorders, or Parkinson's disease (Fino et al., 2016; Huisinga et al., 2017; Lim et al., 2017; Yamagata et al., 2017; Han et al., 2018; MacRae et al., 2018; Nikaido et al., 2018). A recent study evaluated COP-irregularity by linking it to PPk(t) irregularity and to the complexity of the movement structure as defined by rSTDk (Haid et al., 2018).

Variables computed on PM time-series contain information about whole-body positioning, which allows studying the movements of the human body as a system, while preserving or possibly enhancing (Federolf P. A. et al., 2013) the ability to discriminate groups. Therefore, the PCA approach is well-suited for addressing any research questions where coordination or the interplay of segment movements is of importance. However, despite its research potential the implementation of PCA approaches requires a fair amount of programming and mathematical skills, and can be very time consuming. Therefore, the development of new PCA based variables and research output validation comparing different computational options is severely hampered.

The main goal of this paper is to present the PManalyzer-software. It generalizes many of the existing PCA concepts and was designed to motivate the development and validation of kinematic PCA related variables and methods within a user-friendly graphical environment. On the one hand, the software will allow researchers and clinicians without extensive programming or mathematical skills to perform PCA on kinematic data; on the other hand, it will allow users with more advanced knowledge in the area to adapt and further develop the software.

Materials and Methods

The software was designed to pre-process the kinematic input data and then compute a PCA on it. Furthermore, the PManalyzer can compute a range of PCA variables. In this section the mathematical background of kinematic feature extraction and some of the most important variables are explained.

General Data Model and Data Pre-processing

Typical kinematic data consists of 3D positions in time obtained by tracking the motion of n anatomical landmarks; either utilizing a motion capture system or video-tracking (Figueroa et al., 2003). The kinematic data is then available in matrix form in which the N = 3·n columns represent the time-series si(t) (i∈{1, 2…, N}) of the respective x-y-z-coordinates of each anatomical landmark. Each row contains the measured 3D positions of all markers at one time-point:

D= [s1(t1)sN(t1)s1(tT)sN(tT) ],

Where T equals the number of measured time-points. The application of PCA to human movement is based on the idea of identifying linear whole-body movement patterns that dominate the recorded movements. However, when identifying movement patterns within a group of several subjects, both the mean positioning of a participant and anthropometrical differences distort the results. To reduce such distortions, the data of each subject can be centered, weighted and normalized (Federolf P. et al., 2013; Zago et al., 2017b; Haid et al., 2018).

The data is centered by subtracting the mean < si> of each individual time-series si (each column) from the respective time-series sic= si-<si >:

Dc= [s1c(t1)sNc(t1)s1c(tT)sNc(tT) ],

preventing differences in mean marker positioning in space to affect the results. Furthermore, a participant's weight distribution can influence marker movements. As an example, when moving a hand, less mass has to be accelerated and controlled, in comparison to moving a thigh. Therefore, each of the N time-series can be scaled according to the weight wi (i∈{1, 2…, N}), that the respective marker represents:

Dc, w= Dc· [w100wN ],

Weighting has been applied in literature (Federolf P. et al., 2013; Gløersen et al., 2017; Haid et al., 2018; Promsri et al., 2018a), often considering gender-specific mass distributions (Defense Technical Information Center, 1988; de Leva, 1996; Gallagher and Heymsfield, 1998).

Another important aspect to be considered when comparing trials is that anthropometric differences can influence the amount of movement produced. Therefore, each data-set should be normalized according to application specific criteria:

Dc, w,n= Dc,w·1dnorm

Normalization factors dnorm such as the mean Euclidean distance (MED) (Federolf P. et al., 2013; Zago et al., 2017b) or the body height (Haid and Federolf, 2018; Haid et al., 2018) have been proposed to reduce anthropometric differences. In detail, the MED ensures that all subjects contribute equally to the overall variance, while the body height normalization scales the data to a trial-independent anthropometric parameter.

Once the data sets of each participant are centered, weighted and normalized1, one large data matrix Dall is formed, containing all data sets of all X trials concatenated vertically (with index 1.X representing different subjects and/or several trials of different subjects):

Dall= [D1c, w,nDX c, w,n]

Feature Extraction—PCA

After pre-processing, the eigenvectors PCkand eigenvalues EVk of the covariance matrix of Dall are computed [implemented as SVD (Shlens, 2014)]. The eigenvectors PCk form a new orthonormal basis that spans posture space (Federolf P. et al., 2013), a space in which each of the axes determines one specific linear, one-dimensional whole-body movement. Furthermore, scores S can be obtained by projecting the data onto the new PCk basis:

S=Dall·PCk    (1)

The k-th column of the score matrix S can be interpreted as time-series PPk(t) that quantitatively describes the evolution over time of the respective principal movement PMk, i.e., the manifestation of the one-dimensional PMk defined by the corresponding PCk:

S= [PP1(t1)PPN(t1)PP1(tT)PPN(tT)]

In addition, the eigenvalues EVk describe the amount of variance (or movement) explained by each PMk and are typically presented as percentages or relative eigenvalues rEVk2.

To compute one PCA on each trial separately can be done by running the software for each trial separately. However, this feature is not explicitly supported, because the authors recommend only comparing trials with respect to one PCA basis that describes the group as a whole. The benefit of the current procedure—being able to compare the PPk(t) of trials—outweighs the benefit of obtaining several, trial-specific PCA-bases that only allow comparisons of rEVk-spectra, but not of PPk(t). Moreover, the PPk(t) can be used to compute variables that describe the subjects specific variance explained by each PMk and further variables that quantify the additional aspects of a movement or of neuromuscular control.

Interpretation of the Movement Components

As mentioned in the previous section, the PCk form a basis of the posture space. Moreover, they have the property that they point in the direction of the largest correlated variance expressed in the data. Therefore, they point in the direction of the most common patterns of correlated marker movements. As a consequence, the PMk are linear approximations of the analyzed movements and interpreting them as real movements should be done with caution. For example, to explain non-linear movements such as rotations at least two linear components are needed. Nevertheless, for movements with small perturbations such as static balancing tasks (tandem, bipedal, one-legged) past research has found the PMk to describe the main dynamics of well established, nonlinear movement strategies, e.g., ankle sway or upper body rotation (Haid and Federolf, 2018; Haid et al., 2018; Promsri et al., 2018a). Moreover, also for movements with higher amplitudes the PMk have been found to reflect the main the dynamics of established movement strategies, such as isolated leg or arm swinging, trunk leaning, or coordinated multi-segment movements (Troje, 2002; Verrel et al., 2009; Eskofier et al., 2013; Gløersen et al., 2017; Zago et al., 2017a,b).

Advantages of analyzing the movement with PMs are that few variables are needed to approximate the movement to great detail and obtaining the PMs is data-driven—not postulated from subjective observations. Moreover, the PMs can be visualized which improves interpretation of results. In the current paper we further propose that movement analysis involving rotational movements of large amplitudes could additionally benefit from non-linear coordinate transformations. To the best of our knowledge, there is no literature to support this assumption, therefore, a motivational example will be presented.

PCA Variables

In the following some of the most common kinematic PCA variables in literature are described. These, amongst others, are pre-implemented in the software.

Trial Specific Movement Structure or Composition

The rEVk determine the overall variance explained by each PMk either in the respective trial—if one PCA is computed for one trial—or in the overall variance produced by all trials—if one PCA is computed for the concatenated trials-matrix. In the latter, trial-specific relative variances rVARk can be computed that represent the explained variance of each PMk (Federolf P. et al., 2013), analogously to the rEVk for applications in which one PCA is computed for each trial. Therefore, the sum of all variances of each trial's individual PPk(t) ~ time-series

totVARtrial:= kVARktrial:=kVAR(PPktrial(t) ),

can be computed. The subject specific relative variances are then defined by

rVARktrial=VARktrialtotVARtrial · 100.

To obtain a similar variable that quantifies the movement structure and explains the relative contributions to a movement, but scales as the original movement, the variance in the rVARk computation can be replaced by the standard deviation to compute trial-specific relative standard deviations rSTDk (Haid and Federolf, 2018; Haid et al., 2018).

When the dimensionality of a movement is of interest, it makes sense to define subject specific cumulative relative variances as

CUM_rVARk:​ =Σ1nkVARntrialtotVARtrial · 100,

or analogously CUM_rSTDk, which explain the cumulative contribution of the respective component order. This can further be used to compute subject specific residual variances

RV3: =100CUM_rVARm=k>mVARktrialkVARktrial  · 100

where m is the highest PC-order included (Zago et al., 2017b,c).

Kinematics in Posture Space and Measures of Postural Control

Similarly to conventional kinematics in biomechanics (Federolf, 2016) the PPk(t) time-series can be utilized to analyze the execution of movements with respect to their PMk. Different trajectories or performances can therefore be directly compared to another if the PPk(t) of all trials are coordinates in the same posture space, i.e., if one only one PCA was computed.

Furthermore, the PPk(t) can be utilized to compute principal velocities PVk(t) and principal accelerations PAk(t) by differentiating the PPk once and twice, respectively. The dynamics of all three PM time-series can be studied using conventional time-series analysis. For example, postural reconfiguration can be ascribed to acting external forces, such as gravity, and internal forces, such as acting muscle forces. Therefore, the PAk(t) can be used to compute variables that characterize the neuromuscular control of movement, as they represent the acceleration of the postural movements. For example, it has been shown that the PAk can be used to quantify the amount and the variability of the neuromuscular control, by further defining variables Nk and σk (Haid et al., 2018; Promsri et al., 2018a), which represent the number of PAk -zero-crossings (changes in the direction in which the neuro-muscular control3 system influences the current motion) and the time-variability between the zero-crossings, respectively.

Table 1 contains a summary and a description of these PCA variables. However, any other type of time-series analysis that fits the research question may be applied to the three PM time-series.

TABLE 1
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Table 1. Summary and description of the variables.

PCA Validity Considerations

To quantify which PCk basis is adequate to describe the group as a whole, a leave-one-out cross-validation can be performed (Diana and Tommasi, 2002; Bro et al., 2008; Camacho and Ferrer, 2012). Therefore, the PCk are computed several times, while omitting one trial each time. The changes between the used PCk and the newly obtained PCk can be quantified as angles and serve as a PM-inclusion criterion (Federolf, 2016; Haid and Federolf, 2018; Haid et al., 2018).

Results—The PManalyzer Software

The Interface

As depicted in Figure 1, the PManalyzer interface is organized into five main panels with red margin and font: 1. “Input data,” 2. “Computation and output,” 3. “Plots,” 4. “Videos” and 5. “Save/Load interface settings.” Following the subpanels one by one allows the user to move through the conventional steps for a PCA applied to kinematic data as described in the section Materials and methods. The block scheme in Figure 2 visualizes the steps of the parameter selection when using the PManalyzer.

FIGURE 1
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Figure 1. General user interface (GUI) of the PManalyzer. The input settings shown here were used for the computation of the example discussed in the current paper.

FIGURE 2
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Figure 2. Block-scheme of the PManalyzer computation options. Gray fields describe essential parameter selections. White field represent optional GUI features (Welch's PSD-estimation can be used to estimate the power spectral density of data and to determine a plausible cut-off frequency).

Once the computational options are selected, the user can save interface settings and reload them later if needed. To improve efficiency when repeating calculation steps, computed data can also be saved, and loaded. The compatibility of the computing vs. loading vs. disabling options is regulated over the interface to avoid the selection of incompatible features.

Note: The interface was created with the “guide” tool in “MATLAB 2015a” in “Windows 10” on a screen with a 1,920 × 1,080 resolution. Both “Units” and “FontUnits” were set to “normalized” with respect to screen size. For other software or hardware configurations (for example on Mac books) some adaptations may be necessary. Also, some of the plotting features may produce errors if the PManalyzer is run on earlier versions of MATLABTM.

Code Structure and Computation

The source code is built upon the structure of the user interface and kinematic PCA described in the methods. To monitor the code activity a text describing the current computational step is printed in the output-console. Furthermore, the code is documented by comments to identify the task of each code section and help identifying important computational variables and their respective role in the code. Despite the self-regulating interface, it is possible to select options that do not match the data. The code has implemented fail-safes to identify obvious selection errors and forward them to the user, e.g., when users choose to make video files of data that was not read in.

Functions containing computational options meant for the user to customize (pre-processing, coordinate transformations, normalizations, weighting, variables on PM time-series, video-coloring and creating additional plots) are contained in the PManalyzer subfolder “FunctionsToEdit.” Users can follow the descriptions and the examples provided inside each function to implement their new options. When starting, the GUI automatically loads all functions contained in subfolders and updates the interface with the available options.

Application Example

In this section, an example computation will be presented to highlight the flexibility of the software. Then, a standard PCA-analysis procedure is outlined. The input is a data subset taken from a previously published tandem stance study that served as template for the PManalyzer (Haid et al., 2018).

Computational Parameters and Modifications

For the sample tandem-stance data the first two columns containing time-frames and the headers were deleted. Then gap-filling (Gløersen and Federolf, 2016) was performed on each data set if needed, and a pre-processing option was created that mirrors specific data to make it comparable (unsymmetrical markers were deleted and data with left foot in front was mirrored). The data was then centered, weighted to standard human mass distribution (Defense Technical Information Center, 1988) and normalized with the height of the participants. We also filtered the data with a low-pass filter of 7 Hz, since Fourier analysis suggested signal power up to this frequency. As this example shows, standard pre-processing options can be performed on all of the data by simple parameter selection.

Another interesting pre-processing option that is rarely taken advantage of in kinematic PCA-research is a coordinate transformation. The PManalyzer has two types of coordinate transformations pre-implemented (spherical and cylindrical). Hence, we recomputed the analysis twice using the same parameter selection as described above, but transforming the data either into spherical or cylindrical coordinates, respectively.

Moreover, we selected several of the standard plotting options for the standard PCA variables (rEVk, rSTDk, rVARk, PP, PV, PA). Further variables such as Nk or σk (Haid et al., 2018; Promsri et al., 2018a) can be computed by selecting “Compute selfdefined variables” and can either be analyzed via Excel output or plotted by defining plots in the function personalizedPlots.m. In addition, we selected several video options (2D, 3D, and three different coloring choices. The Supplementary Files contain a summary of the important results of these computations, which we will discuss in the following section.

PCA Results

As a common first step, the overall eigenvalues were analyzed to see how much overall variance can be explained by the components (individually or cumulatively). These results (Figure 3) show that using spherical or cylindrical coordinate transformations would allow to explain more variance with fewer components. Therefore, we chose to continue the analysis with the results obtained by using spherical coordinates.

FIGURE 3
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Figure 3. Eigenvalue and cumulative eigenvalue spectra obtained from three coordinate systems (standard kinematic PCA applications use Cartesian-coordinate systems). To explain roughly 98% of the variance it takes 9 PMs using Cartesian, 8 PMs using polar and 6 PMs using spherical coordinates.

As a next step, the PM-movies can be used to describe the movement components to form a better understanding of the extracted movements (compare “ColoringNone_2D_PM1-5_vis.mp4”). It is often helpful to implement specific coloring options (compare “Coloring1_2D_PM1-5_vis.mp4” and “Coloring1_2D_PM1-5_vis.mp4”). For this sample data, the first principal movement resembled an anteroposterior ankle sway. The second PM resembled an upper body retraction accompanied by front knee flexion, etc. The amplification factors displayed in the titles can be adjusted individually for every PMk. This is helpful when identifying movements of different magnitudes.

Furthermore, PM time-series plots show the execution of the individual trials with respect to the extracted movements (see Figure 4) and the PP activity over time can also be displayed in the video option (“Subject1_2D_PM-5.mp4” and “Subject1_3D_PM-5.mp4”). Both can be useful developing hypotheses related to the dynamics of PMs or their interplay. Users may define any sort of variable in the function optionsVariablesComp.m. These variables can then be computed on PPk -, PVk- and PAk-time-series, thus describing specific aspects of movement components that were not a priori defined, but play an important role producing the observed variance. As an example, we plotted the trial specific relative variances rVARk and standard deviations rSTDk that have been very useful when comparing movement structures amongst various groups (Federolf, 2016; Haid et al., 2018; Promsri et al., 2018a). In the current example it can be observed that while the overall movement of subject 2 is dominated by anteroposterior ankle sway, subject 3 has a more balanced movement structure, where several movements contribute effectively (Figure 5).

FIGURE 4
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Figure 4. Exemplary PP-, PV- and PA-time-series produced by the PManalyser. This specific data was recorded from a subject performing a tandem stance balance trial. The number of trials, subjects and PMs displayed per figure can be selected in the interface. Units are arbitrary (AU), since they represent a combined motion of all markers and may depend on pre-processing options.

FIGURE 5
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Figure 5. Subject specific relative variances and standard deviations (rSTD and rVAR) for five subjects performing a tandem stance, using spherical coordinates. These eigenvalues are useful to compare the coordinative structure of a movement. In a similar fashion to Figure 3 the cumulative versions of the variables can also be plotted with the software.

Discussion

Application of PCA-Variables

In human movement analyses, one of the most important steps is the reduction of the numerous degrees of freedom. Several approaches have been proposed in order to reduce the DOF while capturing the most important dynamics of human movements. For example, in static balance research, one of the most common approaches is to quantify the center of pressure movement, reducing the complex whole-body kinematics to the resultant point where the vertical ground reaction forces act. Indeed, COP based variables proved to be effective at distinguishing different pathological groups and different balancing conditions. However, literature findings are inconsistent and some interpretations are controversial. For example, COP-irregularity has been interpreted as a sign of very active and effective postural control (Cavanaugh et al., 2006; Donker et al., 2007; Haran and Keshner, 2008; Stins et al., 2009; De Beaumont et al., 2011), but also as a sign of a disordered and less effective control (Donker et al., 2007; Stins et al., 2009; Borg and Laxåback, 2010; Gao et al., 2011).

Reducing the DOF via PCA has helped to address some of the inconsistencies in COP literature. As a first step it was shown that the information contained in the COP-excursion should also be contained in PCA variables, since the COP-trajectories can be calculated from the PPk and PAk time series (Federolf, 2016). Then, follow-up research found that COP-irregularity correlates with both the mechanical complexity of the movement, as quantified by the movement structure rSTDk, and the irregularity of the neuromuscular control as quantified by PPk-irregularity (Haid and Federolf, 2018). Hence, these findings suggest that COP-irregularity depends on more than one interacting phenomenon, possibly explaining some of the controversial results.

As another example, in research areas that involve postural control and motor control theories, e.g., neurosciences, distinguishing movement strategies can be of great importance. For example, the minimal intervention principle MIP, as discussed in the context of the optimal feedback control theory (Todorov and Jordan, 2002), states that postural control focuses on task relevant movements, while allowing variability in redundant ones. Furthermore, evidence suggests that ankle, knee and hip strategies dominate the whole-body kinematics of balancing tasks (Gage et al., 2004; Kuznetsov and Riley, 2012). In addition, coherence analyses of respective joint angles (Kilby et al., 2015; Masumoto and Inui, 2015) and muscle-EMGs (Alfuth and Gomoll, 2018; Pollock et al., 2019) suggest that these strategies are coordinated (Huisinga et al., 2017; Shahvarpour et al., 2018). Nevertheless, further evidence suggests that when modeling the dynamics according to these segment interactions (Oliveira et al., 2017; McNair et al., 2018), the models seem unable to explain the full extent of the movement dynamics (Hume et al., 2019). Hence, since these studies depend on only a few pre-selected muscles and DOF they might be limited when testing hypotheses related to the MIP.

The advantage of the PCA approach is that the extracted principal movement components are inherent in the data. They represent coordinated marker movements that generate quantifiable amounts of the overall variance produced by the analyzed movement. This allows categorizing them with respect to their relative contribution to the overall movement and to determine a movement's composition of PM, i.e. the movement structure (rSTD). Furthermore, the respective PM-time-series can be used to quantify novel aspects of postural control, such as how tight a movement is controlled (how often the control system intervenes (Nk) and how variable the control (σk) of the respective PMk is). As an example, in accordance with the MIP the tandem stance study mentioned in the results of this paper (Haid et al., 2018) found that aging effects emerged in the movement structure and control of specific, task relevant components, but did not affect other movement components. In detail, the movement component with the least base of support exhibited less relative contribution and tighter control in the younger age group. Also leg dominance was studied in a similar fashion (Promsri et al., 2018b) revealing differing movement control characteristics in different movement components.

In addition, the PCA variables were used in several studies with clinical purposes, or for fundamental research. Specifically, they were helpful to classify gait patterns that are a result of spastic diplegia (Zago et al., 2017c), affect (Karg et al., 2010), gender or age (Troje, 2002; Verrel et al., 2009; Eskofier et al., 2013), or shoe material (Maurer et al., 2012; von Tscharner et al., 2013). Principal movements were also calculated as pre-processing step in research on work-related musculoskeletal disorders that aimed at characterizing the variability and the local dynamic stability of the movements (Longo et al., 2018a,b). The PM calculation allowed distinguishing cycle-to-cycle variability from changes in the overall postural configuration—a prerequisite for the calculation of non-linear variables such as the largest Lyapunov exponent in this context. In sports, coordinative strategies were studied, by identifying and quantifying PCA-eigenvectors, eigenvalues and score time-series, for example in alpine skiing (Federolf et al., 2014), cross-country skiing (Gløersen et al., 2017), Karate (Zago et al., 2017a), dancing (Masurelle et al., 2013), cycling (Moore et al., 2011), diving (Young and Reinkensmeyer, 2014), and race-walking (Donà et al., 2009).

In summary, literature suggests that kinematic PCA can be an effective tool to study pathological conditions or sport performance, and to address unsolved problems of motor control theories such as the minimal intervention principle. The basic code structure of the PManalyzer was originally developed for the tandem stance study (Haid et al., 2018). Later, the code was further developed to be applicable in a wider range of static balancing tasks. However, as discussed in the following section, it is also modifiable to be used in other application areas.

Computational Features and Advantages of the Software

The main purpose of the PManalyzer software was to make PCA computations more easily accessible for users, particularly for users less familiar with programming or with the mathematical background of PCA applications. The PManalyzer offers the broad spectrum of available computational options and the large variety of easily customizable visualization options. It also allows a user to perform pre-processing steps like PCA-based gap-filling (Gløersen and Federolf, 2016), deleting markers, columns or rows, or to integrate any other self-defined data pre-processing steps. Additionally, the PManalyzer can transform data from a Cartesian into a spherical or polar coordinate system. Users with more advanced mathematical knowledge can implement further coordinate transformations. Moreover, a number of pre-defined normalization options are available, of which two have been validated (mean Euclidean distance and height) through previous research (Federolf P. et al., 2013; Zago et al., 2017b; Haid et al., 2018; Promsri et al., 2018a), while others (such as maximum movement range in x, y, or z direction) have yet to be explored. Also the weighting options for the standard 39 and 37 (no fingers) plug-in gate marker systems are pre-implemented, as well as the specialized 28 marker system (only symmetric markers) used in the tandem stance study of the results (Haid et al., 2018).

Furthermore, new variables can easily be implemented to be computed on all PM-time-series. If selected, they will be saved with the other variables on the PP-, PV- and PA-time-series (rVAR, rSTD, N, σ, RMS, mean, standard deviation, amongst others). For users not familiar with Matlab programming, the results of all computed variables can be exported to an Excel spread sheet. Moreover, users can create customized plots that are directly integrated into the interface. Finally, any video coloring option can be added to the software without extensive Matlab skills, saving programming time and effort.

To validate the obtained basis PCk, a leave one out cross-validation has been implemented that produces a figure displaying the angle-changes as described in section PCA validity considerations. Furthermore, a figure containing a Welch's power spectral density estimate can be created to help determine a suitable filtering frequency. Moreover, specifying a vector of cut-off frequencies will run the selected PCA-computations consecutively with different filtering cut-off frequencies and saving the results in separate folders. This is particularly useful, in order to conduct a frequency analysis to ensure that statistical results are stable for various cut-off frequencies (Haid and Federolf, 2018; Haid et al., 2018; Promsri et al., 2018a).

Limitations and Future Research Potential

When it comes to effectively applying kinematic PCA and to establishing reliable norm values for a clinical and sports related environment, several factors should be considered. First, kinematic PCA is only one of many interesting feature extraction algorithms. For example, independent component analysis (von Tscharner et al., 2013), isometric feature mapping (Blackburn et al., 2003) and linear discriminant analysis (Karg et al., 2010) have been used as kinematic feature extraction tools and shown to outperform PCA in specific situations. Hence, there is tremendous potential for systematic research into the advantages and disadvantages of PCA compared to several other feature extraction techniques (Van Der Maaten et al., 2009).

Second, in order to establish norm values it is essential to define standard procedures. Hence, marker systems, pre-processing options, normalization and weighting, and coordinate transformations must be explored and standardized for different types of movements. Specifically, coordinate transformations are an interesting, yet relatively unexplored feature in kinematic PCA. As an example, the tandem-stance study analyzed nine different ankle, knee, upper body and head strategies, explaining 98% of the overall variance. The results in this study show that only 6 PMs would be necessary to achieve the same accuracy, if spherical coordinates were used. Furthermore, also moving coordinate systems offer unexplored potential. The example of alpine skiing technique analysis (Federolf et al., 2014) shows that body-positioning-dependent coordinate systems can help focus the analysis by neglecting movements with respect to specified planes. A similar, implemented pre-processing feature in the PManalyzer is the pre-processing option that moves the coordinate system into the center of mass, which can be used to avoid body displacements being represented as PMs.

Third, PCA based variables described in this study have been applied successfully to quantify movement coordination and complexity (rEV, rVAR, rSTD, and RV), and movement control (N, σ, PP-irregularity), amongst others. However, especially the variables of movement control computed on the PA-time-series (N, σ) react sensitively to the quality of kinematic data and filtering settings, due to double differentiation of the data. Nevertheless, a frequency analysis of the variables of movement control indicated that the underlying effects are robust to changes in filtering frequency and not random artifacts (Haid and Federolf, 2018; Haid et al., 2018; Promsri et al., 2018a). Hence, it should be possible to use PCA variables to establish objective norm values that describe movement performance. However, follow-up research is needed to further validate existing variables and possible to develop new ones.

Finally, the extracted principal movements must be carefully interpreted. Each PM is defined by one linear movement of each marker. Since real whole-body movements are usually not linear, individual PMs can only approximate real movements, at best. However, some of the PMs obtained from movements with small amplitudes, such bipedal static balancing tasks (Federolf, 2016; Haid et al., 2018), seem to be realistic approximations of movement strategies that were already described in the literature, such as ankle sway and hip-strategies (Gage et al., 2004; Kuznetsov and Riley, 2012; Kilby et al., 2015). Others, such as certain upper body strategies have not been described in literature but seem realistic in the author's eyes. Furthermore, non-linear movements with higher amplitudes would require at least two or more PMs to be approximated in a realistic way. In theory, this limitation could be overcome with specialized non-linear coordinate transformations or other feature extraction techniques. At the moment, evidence suggests that the PMs of higher amplitude movements describe interesting features that allow group classifications, e.g., gait recognition (Troje, 2002; Verrel et al., 2009; Karg et al., 2010) or sport performance (Donà et al., 2009; Federolf et al., 2014; Young and Reinkensmeyer, 2014). However, further research is needed to link specific linear PM-combinations to realistic non-linear movements.

In terms of the PManalyzer, some of the GUI options, for example weighing markers according to the segment masses they represent, depend on the input data (number and distribution of markers) and the type of movement analyzed. A flexible usage requires the user to define these options for non-standardized input data, since, specifically for these options, the software relies on pre-implemented options rather than on software recognition. However, only basic, easily acquirable Matlab knowledge is needed to follow the templates in the editable functions and to perform such changes in the according functions. Furthermore, despite beta testing, bugs can never be excluded. Nevertheless, we are confident that the software works well, as it has been tested on various data sets (Haid and Federolf, 2018; Haid et al., 2018; Longo et al., 2018a,b, 2019; Promsri et al., 2018a,b), yielding the expected results. We encourage the community to report possible improvements to the authors.

Conclusions

We presented the PManalyzer, a software tool that is meant as a basis code for applying PCA in the analysis of human movement and its sensorimotor control. We hope this will encourage colleagues to more often apply PCA in their movement control related research. The computational options are not meant to be complete, but rather to enable easy software modifications to assist future users in the development of specialized applications.

Ethics Statement

The example data in section Discussion was taken from a study that was conducted in agreement with the Declaration of Helsinki, in particular, an institutionalized ethics review board had approved the study design and informed written consent was obtained from all volunteers prior to any measurements.

Author Contributions

TH developed and implemented the PManalyzer, and wrote the first draft of the paper, the quick start guide and the user's manual, constantly updating the software and the manuscripts. MZ validated the software's computational steps, by comparing the PCA outputs to previously published results, and repeatedly revised both the paper and the starter guide. AP contributed by challenging several software-updates as they became available and helped eliminating numerous update-bugs. She also gave valuable insights on how to improve the software's usability and revised the starter guide. A-CD tested the functionality and adaptability of the software, improving code-documentation and contributed to the manuscript and the quick start guide. PF contributed as mentor and PCA-teacher, which lead to the PManalyzer software project. For this paper he was also deeply involved in the writing-process, improving its structure, and wording. Moreover, his regular and critical software evaluations drastically improved the PManalyzer.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Acknowledgments

We would like to thank all students and co-workers involved in testing early versions of the software for their feedback. Particularly, Julian Kiefer, Roman Rethwilm, Inge Werner, Alessia Longo, and Felix Wachholz.

The current study was an internal research project that did not receive external funding. Internal university grants may cover parts of the open access publishing costs after the paper has been published.

Supplementary Material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fninf.2019.00024/full#supplementary-material Supplementary materials (the PManalyzer software, documentation, data examples and video files) can be found online at: https://www.uibk.ac.at/isw/forschung/neurophysiologie-bewegungswissenschaft/software.html.

The website contains the most recent, updated versions of the software, a quick start guide “GettingStarted_PManalyzer.docx” and a user's manual (“UsersManual_PManalyzer.pdf”).

Footnotes

1. ^The default order in the software is centering, then weighting and finally normalizing the individual data sets. Depending on the pre-processing selection, the order might influence the results.

2. ^In literature the “relative eigenvalues” rEVk are sometimes referred to as EVk out of simplicity. In addition, the term “relative eigenvalues” may refer to the “trial specific relative variances” as described in the following section. In this manuscript we aim at consistency.

3. ^Residual variances can also be computed for the overall contributions by substituting the rVARk with the rEVk.

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Keywords: sensorimotor control, motion analysis, clinical gait analysis, postural control, coordination, principal component analysis PCA

Citation: Haid TH, Zago M, Promsri A, Doix A-CM and Federolf PA (2019) PManalyzer: A Software Facilitating the Study of Sensorimotor Control of Whole-Body Movements. Front. Neuroinform. 13:24. doi: 10.3389/fninf.2019.00024

Received: 24 August 2018; Accepted: 18 March 2019;
Published: 05 April 2019.

Edited by:

Antonio Fernández-Caballero, University of Castilla La Mancha, Spain

Reviewed by:

Karen Zentgraf, Goethe-Universität Frankfurt am Main, Germany
Thorsten Stein, Karlsruhe Institute of Technology (KIT), Germany

Copyright © 2019 Haid, Zago, Promsri, Doix and Federolf. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Thomas H. Haid, thomas.haid@uibk.ac.at