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Front. Synaptic Neurosci. | doi: 10.3389/fnsyn.2018.00042

The role of calcium-permeable AMPARs in long-term potentiation at principal neurons in the rodent hippocampus

 Pojeong Park1, 2, 3, 4,  Heather Kang2, 3, 4, Thomas M. Sanderson1, 4,  Zuner A. Bortolotto4,  John Georgiou3, 5,  Min Zhuo1, 2,  Bong-Kiun Kaang1 and  Graham L. Collingridge1, 2, 3, 4*
  • 1Seoul National University, South Korea
  • 2University of Toronto, Canada
  • 3Lunenfeld-Tanenbaum Research Institute, Canada
  • 4University of Bristol, United Kingdom
  • 5Sinai Health System, Canada

Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the PKA- and protein synthesis-dependent component of LTP.

Keywords: NMDA receptor, long-term potential (LTP), Hippocampus (CA1), calcium-permeable AMPA receptors, synaptic tagging

Received: 15 Sep 2018; Accepted: 05 Nov 2018.

Edited by:

Karri P. Lamsa, University of Szeged, Hungary

Reviewed by:

Lisa Topolnik, Laval University, Canada
Tomi Taira, University of Helsinki, Finland  

Copyright: © 2018 Park, Kang, Sanderson, Bortolotto, Georgiou, Zhuo, Kaang and Collingridge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Graham L. Collingridge, Seoul National University, Seoul, South Korea, collingridge@lunenfeld.ca