Frontiers in Synaptic Neuroscience

Review

Published on 10 Dec 2025

Synaptic transmission in supragranular layers of the human cortex – comparative review of structure, function, and plasticity

Amelie Eichler
Pia Kruse
Charlotte Schob
Maximilian Lenz

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1724377

365 views

Mini Review

Published on 09 Dec 2025

From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation of in vitro neural circuits

Song Wang
Sarah Gordon
Chris French
Ranjith R. Unnithan
Dechuan Sun

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1732955

335 views

Review

Accepted on 24 Nov 2025

Aging and Alzheimer's: The Critical Role of Mitochondrial Dysfunction and Synaptic Alterations

Pinky Pinky
Zitin Wali
Neha Neha
Prachi Tiwari
Mohamed El-Tanani
Syed Arman Rabbani
Suhel Parvez

Frontiers in Synaptic Neuroscience

170 views

Original Research

Published on 18 Nov 2025

GABAB receptors negatively modulate excitatory plasticity at the mossy fiber synapse onto parvalbumin-expressing basket and axo-axonic cells in the dentate gyrus

Rita M. Loureiro
Sam A. Booker
Akos Kulik
Imre Vida

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1656759

1,150 views

Brief Research Report

Published on 05 Nov 2025

Opposite serotonergic modulation of sharp waves in the dorsal and ventral hippocampus

Charalampos L. Kandilakis
Costas Papatheodoropoulos

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1701349

1,054 views

Review

Published on 15 Oct 2025

Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations

Agnieszka Pawlak
Jakub Stefanowicz
Zofia Kotkowska
Agata Gabryelska
Marcin Sochal
Filip Napieraj
Magdalena Kotlicka-Antczak
Dominik Strzelecki

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1656232

3,011 views

Review

Published on 10 Oct 2025

AMPA receptors in the evolving synapse: structure, function, and disease implications

Fleming Francis
Dewan Chettri
Deepak Nair

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1661342

2,720 views

Mini Review

Published on 02 Oct 2025

Exploring the singularity of human neurons: keep calm and carry on

Baptiste Libé-Philippot

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1672646

2,250 views

Original Research

Published on 13 Aug 2025

PKMζ drives spatial memory reconsolidation but not maintenance

João Rodrigo de Oliveira
Janine I. Rossato
Johseph P. G. Souza
Rodrigo Orvate
Livia Carneiro
Ana Luizi Baracho
Martín Cammarota

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1638371

2,300 views

Original Research

Published on 05 Aug 2025

Morphological variability may limit single-cell specificity to electric field stimulation

Daniel Trotter
Aref Pariz
Axel Hutt
Jérémie Lefebvre

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1621352

1,947 views

Original Research

Published on 27 May 2025

Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux

Jyotsna Mishra
Kyle Bevers
Keguo Li
Armaan Zare
James S. Heisner
Ailing Tong
Wai-Meng Kwok
David F. Stowe
Amadou K. S. Camara

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1562065

3,113 views

Original Research

Published on 25 Apr 2025

A novel peptide inhibitor of TRPM2 channels improves recovery of memory function following traumatic brain injury

James E. Orfila
Robert M. Dietz
Christian Schroeder
Olivia P. Patsos
Amelia Burch
Kiara E. Bahamonde
Kelley A. Coakley
Danelle J. Carter
Amy C. Clevenger
Tara B. Hendry-Hofer

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1534379

3,088 views
2 citations

Original Research

Published on 14 Apr 2025

High frequency stimulation activates hot spots of spontaneous synaptic transmission

Herson Astacio
Maria Bykhovskaia

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1539868

2,099 views

Original Research

Published on 04 Apr 2025

A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping

Thomas M. Bartol
Mariam Ordyan
Terrence J. Sejnowski
Padmini Rangamani
Mary B. Kennedy

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1547948

3,289 views
3 citations

Original Research

Published on 17 Feb 2025

Postsynaptic spiking determines anti-Hebbian LTD in visual cortex basket cells

Christina Y. C. Chou
Wouter J. Droogers
Txomin Lalanne
Eric Fineberg
Tal Klimenko
Hannah Owens
P. Jesper Sjöström

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2025.1548563

2,571 views

Brief Research Report

Published on 20 Dec 2024

β-adrenergic receptor-induced E-S potentiation in the dorsal and ventral hippocampus

George Trompoukis
Athina Miliou
Costas Papatheodoropoulos

Frontiers in Synaptic Neuroscience

doi 10.3389/fnsyn.2024.1511485

1,864 views
1 citation