@ARTICLE{10.3389/fphys.2012.00468, AUTHOR={Kohr, Mark and Roof, Steve and Zweier, Jay and Ziolo, Mark}, TITLE={Modulation of myocardial contraction by peroxynitrite}, JOURNAL={Frontiers in Physiology}, VOLUME={3}, YEAR={2012}, URL={https://www.frontiersin.org/articles/10.3389/fphys.2012.00468}, DOI={10.3389/fphys.2012.00468}, ISSN={1664-042X}, ABSTRACT={Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca2+ handling, proposed signaling pathways, and protein end-targets.} }