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Front. Physiol. | doi: 10.3389/fphys.2017.00975

Genetic Association between Matrix Metalloproteinases Gene Polymorphisms and Risk of Prostate Cancer: A Meta-Analysis

  • 1Department of Urology, Zhongnan Hospital, Wuhan University, China
  • 2Department of Urology, Xi'an Jiaotong University, China

Background and Objective: Studies suggests that matrix metalloproteinase (MMP)-2 -1306 C/T and MMP-1 -1607 1G/2G polymorphisms affect the risk of prostate cancer. However, the conclusions remain controversial and no pooled evidence of this topic has been published. Therefore, we aimed to perform a meta-analysis to shed some light on the controversial conclusion pertaining to the associations of MMP-2 -1306 C/T and MMP-1 -1607 1G/2G polymorphisms with prostate cancer susceptibility.

Methods: A thorough literature search was performed up to August, 2016 with the PubMed, EMBASE, CBM, CNKI, and Wanfang databases. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated to address the correlations between these polymorphisms and risk of prostate cancer.

Results: The meta-analysis included six studies (1921 patients and 1988 controls) on MMP-2 -1306 C/T polymorphism and three studies on MMP-1 -1607 1G/2G polymorphism (438 patients and 394 controls), respectively. The overall results of meta-analysis showed that an elevated risk of the disease was implicated inMMP-2 -1306 C/T polymorphism under two genetic models (CT vs. CC: OR = 1.78, 95% CI = 1.33-2.38; TT+CT vs. CC: OR = 1.62, 95% CI = 1.24-2.12) and no significant association was observed between MMP-1 -1607 1G/2G polymorphism and the risk of prostate cancer. The subgroup analysis results of MMP-2 -1306 C/T polymorphism were similar to the overall results. However, decreased risk of prostate cancer was observed in the Caucasians for MMP-1 -1607 1G/2G polymorphism.

Conclusions: Current meta-analysis indicates that MMP-2 -1306 C/T polymorphism is associated with elevated risk of prostate cancer, but MMP-1 -1607 1G/2G polymorphism may inhibit the occurrence of prostate cancer in Caucasians. Further studies are warranted to verify the conclusions.

Keywords: prostate cancer, Matrix Metalloproteinases, Meta-analysis, Polymorphism, Single Nucleotide, Genetic Variation

Received: 17 Jul 2017; Accepted: 15 Nov 2017.

Edited by:

Brian J. Morris, University of Sydney, Australia

Reviewed by:

Alberto Passi, University of Insubria, Italy
Kirsty Pringle, University of Newcastle, Australia  

Copyright: © 2017 Weng, Zeng, Wang, Liu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Xing-Huan Wang, Zhongnan Hospital, Wuhan University, Department of Urology, Wuhan, China,