%A Zhang,Xiao-Guang %A Shan,Chang %A Zhu,Jia-Zhen %A Bao,Xiao-Yi %A Tong,Qiang %A Wu,Xi-Fan %A Tang,Xiao-Chen %A Xue,Ting %A Liu,Jie %A Zheng,Guo-Qing %A Wang,Yan %D 2018 %J Frontiers in Physiology %C %F %G English %K Mesenchymal Stem Cells,Borneol,Stroke,Neurogenesis,Neuroprotection %Q %R 10.3389/fphys.2017.01133 %W %L %M %P %7 %8 2018-January-17 %9 Original Research %+ Jie Liu,Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine,China,liujie3131@tongji.edu.cn %+ Guo-Qing Zheng,Department of Internal Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,China,gq_zheng@sohu.com %+ Yan Wang,Department of Internal Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,China,wywzchina@sina.com %# %! Mesenchymal stem cells and borneol for ischemic stroke %* %< %T Additive Neuroprotective Effect of Borneol with Mesenchymal Stem Cells on Ischemic Stroke in Mice %U https://www.frontiersin.org/articles/10.3389/fphys.2017.01133 %V 8 %0 JOURNAL ARTICLE %@ 1664-042X %X Intravenous stem cell transplantation initiates neuroprotection related to the secretion of trophic factor. Borneol, a potential herbal neuroprotective agent, is a penetration enhancer. Here, we aimed to investigate whether they have additive neuroprotective effect on cerebral ischemia. Borneol was given to mice by gavage 3 days before middle cerebral artery occlusion (MCAO) induction until the day when the mice were sacrificed. Mesenchymal stem cells (MSCs) were intravenously injected at 24 h after MCAO induction. Neurological deficits, infarct volume, cell death, and neurogenesis were evaluated. Combined use of MSCs and borneol could more effectively reduce infarction volume and cell apoptosis, enhance neurogenesis, and improve the functional recovery than that of MSCs alone. The findings showed that combined use of borneol and stem cells provided additive neuroprotective effect on cerebral ischemia. However, the supposed effect of borneol on the improved MSC penetration still needs further direct evidence.