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Front. Physiol. | doi: 10.3389/fphys.2018.00135

The role of Sirt6 in obesity and diabetes

Jiangying Kuang1, Lei Chen1, Qin Tang1, Jinhang Zhang1, Yanping Li1 and  Jinhan He1*
  • 1Sichuan University, China

Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase and ADP-ribose transferase enzyme. It has an important role in physiological and pathological processes, regulating aging, cancer, obesity, insulin resistance, inflammation, and energy metabolism. Recent studies have suggested that reduced Sirt6 action is related to obesity and diabetes. Aging and overnutrition, two major risk factors for obesity and diabetes, lead to decreased Sirt6 level and function, which results in abnormal glucose and lipid metabolism. Whole-body ablation of Sirt6 in mice results in severe hypoglycemia. Sirt6 deficiency leads to liver steatosis and promotes diet-induced obesity and insulin resistance. Sirt6 has a protective effect on obesity and diabetes. This review surveys evidence for an emerging role of Sirt6 as a regulator of metabolism in mammals and summarizes its major functions in obesity and diabetes.

Keywords: SIRT6, Obesity, Diabetes Mellitus, Type 2, LiPo, Gluconeogenesis

Received: 07 Jan 2018; Accepted: 12 Feb 2018.

Edited by:

Dechun Feng, National Institute on Alcohol Abuse and Alcoholism, United States

Reviewed by:

Hua Wang, Anhui Medical University, China
ZIyi Liu, National Institutes of Health (NIH), United States  

Copyright: © 2018 Kuang, Chen, Tang, Zhang, Li and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Jinhan He, Sichuan University, Chengdu, China, jinhanhe@scu.edu.cn