The complex role of store operated calcium entry pathways and related proteins in the function of cardiac, skeletal and vascular smooth muscle cells
- 1Fisiología Médica y Biofisica, Universidad de Sevilla, Spain
- 2Fisiología, Facultad de Veterinaria, Universidad de Extremadura, Spain
Cardiac, skeletal and smooth muscle cells shared the common feature of contraction in response to different stimuli. Agonist-induced muscle’s contraction is triggered by a cytosolic free Ca2+ concentration increase due to a rapid Ca2+ release from intracellular stores and a transmembrane Ca2+ influx, mainly through L-type Ca2+ channels. Compelling evidences have demonstrated that Ca2+ might also enter through other cationic channels such as Store-Operated Ca2+ Channels (SOCCs), involved in several physiological functions and pathological conditions. The opening of SOCCs is regulated by the filling state of the intracellular Ca2+ store, the sarcoplasmic reticulum, which communicates to the plasma membrane channels through the Stromal Interaction Molecule 1/2 (STIM1/2) protein. In muscle cells, SOCCs can be mainly non-selective cation channels formed by Orai1 and other members of the Transient Receptor Potential-Canonical (TRPC) channels family, as well as highly selective Ca2+ Release-Activated Ca2+ (CRAC) channels, formed exclusively by subunits of Orai proteins likely organized in macromolecular complexes. This review summarizes the current knowledge of the complex role of Store Operated Calcium Entry (SOCE) pathways and related proteins in the function of cardiac, skeletal and vascular smooth muscle cells.
Keywords: Ca2+, Orai, STIM, TRPC., cardiomyocytes, skeletal muscle, vascular smooth muscle
Received: 07 Jan 2018;
Accepted: 06 Mar 2018.
Edited by:Fabio Mammano, Istituto di Biologia Cellulare e Neurobiologia (CNR), Italy
Reviewed by:John C. Chatham, University of Alabama at Birmingham, United States
Cristina Fasolato, Università degli Studi di Padova, Italy
Copyright: © 2018 Avila-Medina, Mayoral, Dominguez-Rodriguez, Gallardo, Ribas, Ordoñez, ROSADO DIONISIO and Smani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Tarik Smani, Universidad de Sevilla, Fisiología Médica y Biofisica, Seville, Spain, email@example.com