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Front. Physiol. | doi: 10.3389/fphys.2018.00287

Mitochondria in Cardiac Postconditioning

Pasquale Pagliaro1*, Saveria Femminò1, Jasmin Popara1 and  Claudia Penna1*
  • 1Scienze Cliniche Biologiche, Università degli Studi di Torino, Italy

Mitochondria play a pivotal role in cardioprotection. Here we report some fundamental studies which considered the role of mitochondrial components (connexin 43, mitochondrial KATP channels and mitochondrial permeability transition pore) in postconditioning cardioprotection. We briefly discuss the role of mitochondria, reactive oxygen species and gaseous molecules in postconditioning. Also the effects of anesthetics - used as cardioprotective substances - is briefly considered in the context of postconditioning. The role of mitochondrial postconditioning signaling in determining the limitation of cell death is underpinned. Issues in clinical translation are briefly considered. The aim of the present mini-review is to discuss in a historical perspective the role of main mitochondria mechanisms in cardiac postconditioning.

Keywords: Cardioprotection, ischemia/reperfusion, Reactive Oxygen Species, redox signaling, Mitochondria, Heart

Received: 24 Jan 2018; Accepted: 12 Mar 2018.

Edited by:

Mariarosaria Santillo, University of Naples Federico II, Italy

Reviewed by:

Giulio Agnetti, Johns Hopkins University, United States
Kerstin Boengler, Justus Liebig Universität Gießen, Germany  

Copyright: © 2018 Pagliaro, Femminò, Popara and Penna. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Pasquale Pagliaro, Università degli Studi di Torino, Scienze Cliniche Biologiche, Regione Gonzole 10 - Orbassano, Turin, 10043, Italy,
Dr. Claudia Penna, Università degli Studi di Torino, Scienze Cliniche Biologiche, Regione Gonzole 10 - Orbassano, Turin, 10043, Italy,