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Front. Physiol. | doi: 10.3389/fphys.2018.00469

Relationship between tumor necrosis factor-α rs361525 polymorphism and gastric cancer risk: a meta-analysis

 Tianshu Xu1,  Zhijun Kong2* and Hui Zhao3*
  • 1Nanjing Drum Tower Hospital, China
  • 2Changzhou No.2 People's Hospital, China
  • 3Wuxi Third People's Hospital, China

Tumor necrosis factor alpha (TNF-α) is an important molecule in inflammatory, infectious and tumor processes, which plays a crucial role in the early stages of gastric cancer (GC). TNF-α rs361525 polymorphism has been demonstrated to be associated with GC risk; however, the association remains conflict and controversial. We therefore conducted this meta-analysis to obtain a more precise estimate of the association of TNF-α rs361525 polymorphism with GC risk. A comprehensive database search of PubMed, Web of Science, EMBASE, and CNKI databases was performed to identify relevant studies through October 5, 2017. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. A total of 20 studies were included in this meta-analysis involving 4,084 cases and 7,010 controls. There was no significant association between TNF-α rs361525 polymorphism and GC risk in the overall populations. In the subgroup analysis, we found that TNF-α rs361525 polymorphism was associated with the increased risk of GC among Asians, while rs361525 polymorphism decreased the risk of GC among Caucasians. Subgroup analysis by genotyping methods revealed increased risk for other methods. In conclusion, this meta-analysis shows that TNF-α rs361525 polymorphism is associated with the risk of GC.

Keywords: tumor necrosis factor alpha, gene polymorphism, Meta-analysis, gastric cancer, Rs361525

Received: 01 Feb 2018; Accepted: 13 Apr 2018.

Edited by:

Stephen J. Pandol, Cedars-Sinai Medical Center, United States

Reviewed by:

Savio George Barreto, Medanta The Medicity, India
Meghit Boumediene Khaled, University of Sidi-Bel-Abbès, Algeria  

Copyright: © 2018 Xu, Kong and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Zhijun Kong, Changzhou No.2 People's Hospital, Changzhou, China, kong_zhijun@sina.com
Dr. Hui Zhao, Wuxi Third People's Hospital, Wuxi, China, hui_1007@163.com