Systematic Review ARTICLE
Dental Findings in Patients With Non-surgical Hypoparathyroidism and Pseudohypoparathyroidism: A Systematic Review
- 1Section for Pediatric Dentistry, Department of Dentistry and Oral Health, Health, Aarhus University, Aarhus, Denmark
- 2Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
- 3Center for Oral Health in Rare Diseases, Department of Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark
- 4Faculté de Chirurgie Dentaire, Institut d'Etudes Avancées, USIAS, FMTS, RARENET Interreg V, Université de Strasbourg, Strasbourg, France
- 5Pôle de Médecine et Chirurgie Bucco-Dentaires, Centre de Référence des Maladies Rares Orales et Dentaires, O-Rares, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
- 6Institut de Génétique et de Biologie Moléculaire and Cellulaire, Centre Européen de Recherche en Biologie et en Médecine, Université de Strasbourg, Centre National de la Recherche Scientifique UMR7104, Institut National de la Santé et de la Recherche Médicale U964, Illkirch, France
Background: Dental aberrations have been mentioned in relation to non-surgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP). However, a systematic review of dental characteristics have not been performed. The present systematic review describes the dental findings in patients with Ns-HypoPT and PHP.
Methods: Studies on Ns-HypoPT and PHP reporting dental features were eligible. A systematic literature search was conducted using four bibliographic databases (Web of Science, Scopus, Pubmed, and Embase) and was limited to studies written in English. Reviews, meta-analyses and letters were excluded. Both the research and reporting of results were based on PRISMA (preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines.
Results: Of 88 studies included, nine were cross-sectional, one was a prospective cohort study, 26 were case series, and 52 were case reports. The most frequently reported findings in patients with Ns-HypoPT were enamel opacities, enamel hypoplasia, hypodontia, and eruption disturbances. In patients with PHP, enamel hypoplasia, eruption disturbance, and deviation of the root morphology were the most frequently reported findings.
Conclusion: An association between enamel hypoplasia and Ns-HypoPT and PHP is likely. The results should, however, be interpreted cautiously due to the limited number of high-quality studies. The present review confirms the need of further well-designed studies, such as large-scale studies, e.g., multicenter studies, to conclude on the reported associations between Ns-HypoPT/PHP and enamel hypoplasia.
Hypoparathyroidism (HypoPT) is characterized by low levels of plasma calcium with inappropriately low levels of parathyroid hormone, as well as high phosphate levels. The most common cause of HypoPT is following neck surgery (Marx, 2000). Non-surgical hypoparathyroidism (Ns-HypoPT) can be induced by various etiologies, either by genetic mutations, autoimmune diseases, radiation, sarcoidosis, or accumulation of iron or cobber. The genetic types are dominated by 22q11 deletion syndrome (22q11DS) and the autoimmune diseases are dominated by autoimmune polyglandular syndrome type 1 (APS 1). The most common genetic reasons for Ns-HypoPT is 22q11 deletion, resulting in hypoplasia of the parathyroid glands. The scientific literature reports that up to 20% of all patients with 22q11 deletion develop chronic HypoPT, and up to 60% of all patients with 22q11 deletion have latent HypoPT (Olesen et al., 2010). Previously, 22q11DS was known as DiGeorge syndrome (OMIM#188400) or Velocardiofacial syndrome (OMIM#192430). Another well-known source of hypocalcemia with low PTH levels is autosomal dominant hypocalcemia (ADH) triggered by an activating mutation in the genes encoding the calcium-sensing receptor (CaSR) mainly placed in the parathyroid glands (Bilezikian et al., 2011). Autoimmune HypoPT is caused by mutations in AIRE, resulting in APS 1 (Bilezikian et al., 2011). The classification and diagnostic criteria of genetic and autoimmune causes of Ns-HypoPT is, however, a challenge. In the literature, idiopathic hypoparathyroidism (IHP) designates HypoPT with unknown etiology.
Pseudohypoparathyroidism (PHP) is characterized by end-organ resistance to PTH. PHP is caused by mutations in either GNAS, STX16, or GNASAS1 on the maternal allele of chromosome 20q13 and is subdivided into groups depending on the clinical and hormonal phenotypes: type 1a (known as Albright Hereditary Osteodystrophy, AHO; OMIM #103580), type 1b (OMIM #603233), type 1c (OMIM#612464), and type 2 (OMIM #203390). Patients with PHP may also have symptoms related to insufficiency of other G-protein coupled hormones, especially TSH. Despite the general peripheral resistance to PTH, patients with PHP may have organ specific variations in their sensitivity to circulating PTH. This is believed to be attributable to genetic imprinting. AHO without biochemical abnormalities is known as pseudopseudohypoparathyroidism (PPHP) and is due to mutation of GNAS on the paternal allele of chromosome 20q13 (OMIM#612463).
A number of dental findings have been reported in relation to the diseases mentioned above (Illum et al., 1981; Jensen et al., 1981). Low levels of PTH in Ns-HypoPT and end-organ resistance to PTH in PHP leads to hypocalcemia. Hypocalcemia is hypothesized as one of the potential causes of disturbances of the tooth development, e.g., enamel opacities and enamel hypoplasia (Garfunkel et al., 1979; Gao et al., 2015). Studies on dental manifestations of the various types of Ns-HypoPT and PHP, e.g., enamel hypoplasia, enamel opacities, hypodontia, root deviations, and eruption disturbances are, however, often mentioned with only few references (Goswami et al., 2009; Velez et al., 2009; Kamarthi et al., 2013). Furthermore, dental findings are often reported as general characteristics of patients with Ns-HypoPT and PHP (Kamarthi et al., 2013).
A number of more recent and larger studies on 22q11DS describe in more details the dental findings in this specific subgroup (Klingberg et al., 2007; Nordgarden et al., 2012). As mentioned above, not all patients with 22q11DS have HypoPT. Thus, a full understanding of the dental features related to Ns-HypoPT and PHP diseases is not available.
The aim of the present study was to conduct a systematic review reporting on dental findings in patients with Ns-HypoPT and PHP.
Materials and Methods
The systematic review was based on PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses; Moher et al., 2009) and contained the PICO elements (Participants, intervention, comparison, outcome, and study design). In collaboration with an experienced research librarian (JLS), the first author conducted the search for relevant publications in four databases, PubMed, Web of Science, Scopus, and Embase.
The literature search was based on the central terms in the classification of genetic and autoimmune causes of hypoparathyroidism (Table 1).
Regarding PICOS, the population was defined through the following key words: “pseudopseudohypoparathyroidism,” “pseudohypoparathyroidism,” “hypoparathyroidism,” “22q11 deletion syndrome,” “DiGeorge syndrome,” and “CaSR gene mutation.” These words were connected with the Boolean operator “OR.” To determine the outcomes, the key words “Enamel hypomineralization,” “enamel hypomineralization,” “dental anomalies,” “root defects,” “impacted tooth,” “tooth impaction,” “enamel hypoplasia,” “tooth malformation,” “tooth defect,” “tooth deviation,” “tooth deviations,” “tooth deviation,” “tooth abnormalities,” “tooth abnormality,” “short root,” “tooth agenesis,” “oral manifestations,” “tooth demineralization,” “dental enamel hypoplasia,” “odontodysplasia,” “anodontia,” “tooth abnormalities,” “dental enamel,” “tooth,” and “teeth” were connected with the Boolean operator “OR.” Both the population and the outcome were connected with the Boolean operator “AND.” Interventions and comparators were not included in the search term due to low number of studies. The full electronic search strategy for PubMed is shown in Figure 1. In addition to the original search, a hand-search of the reference lists of the publications entered into the review was performed, with special focus on the known Scandinavian authors, e.g., Børglum, Klingberg, and Nordgarden (Børglum Jensen et al., 1983; Klingberg et al., 2005; Nordgarden et al., 2012). Lastly, an additional search on Scandinavian languages (Danish, Swedish, and Norwegian) was performed.
Selection Criteria and Data Extraction
After identification of relevant publications, the duplicates were removed. The selection of publications was conducted in two phases, based on (1) the title and abstract, and (2) the full-text publication (Figure 2). The abstracts were included when they met the following inclusion criteria or when the first author was in doubt. All original reports, studying dental characteristics in Ns-HypoPT and PHP, were considered eligible for the present review. The systematic literature search included publications published in English up to date (January 2018). The exclusion criteria was as following: not original research publications (reviews, editorials, conference abstract, book chapter, letter, or commentaries), topic different from dental findings, animal studies, description of patients without teeth or newborn, publications without specification of dental anomalies, patients not suffering from Ns-HypoPT or PHP, and languages different from English, Danish, Swedish, or Norwegian.
The reasons for exclusion of publications are mentioned in Figure 2. The publications were inserted into the EndNote X8® software, and a list of references was generated for further analysis and selection.
We aimed to assess the publications according to Newcastle-Ottawa Quality Assessment Scale (Hospital, 2014) (NOS), Centre for Evidence-Based Medicine (CEBM) (Medicin, 2017), and Strength of Recommendation Taxonomy (SORT) (Ebell et al., 2004). Results were reported in five tables, two concerning Ns-HypoPT (Tables 2, 3), and another two related to PHP (Tables 4, 5) and one related to quality assessment (Table 6).
Data extraction was carried out using a tailored form that had been pilot-tested. The first author carried out the data extraction.
During the quality assessment, some of the findings were challenging, such as Fraser and co-workers publishing the same study in 1979 (Nikiforuk and Fraser, 1979), and in1981 (Nikiforuk and Fraser, 1981) and in 1982 (Fraser and Nikiforuk, 1982). Therefore, the findings in these three publications were included only once in the present review. The study by Garfunkel et al. (1979) was a histological assessment of teeth extracted from patients in the study by Pisanty et al. (Pisanty and Garfunkel, 1977). The reported findings were identical in both publications. Therefore, the findings were included only once. In addition, the reported treatment-related findings and soft tissue findings were not included, as these topics were not a part of the aim of the present review (Klingberg et al., 2002; Bruserud et al., 2016). Selective reporting and observational bias might be a risk, as case series and case reports were included, and this may affect the cumulative evidence.
The first author conducted the two selection phases based on the abstracts and the full-text publications. If difficulties in the interpretation of the information in the publications appeared, consensus was reached between the first author and two other authors (HG and DH). The results of the data extraction are displayed in Tables 2–5.
After having performed a systematic literature search, it became clear that the number, character, and quality of the publications on the subject were at a relatively low scientific level to provide a basis for making a systematic review according to the guidelines in NOS, CEMB, and SORT. High quality studies were almost absent, as most of the studies were case reports and case series (Tables 2–5). However, nine studies on Ns-HypoPT were cross-sectional studies, and one on Ns-HypoPt was a prospective cohort study. Using NOS for cohort studies, none of these studies were classified as high quality (Table 6). None of the studies concerning PHP met the inclusion criteria for NOS assessment. All studies were included in the review due to low number of quality studies. The reported diagnoses in the publications included in the present study were categorized according to the classification given in Table 1.
Tables 2–5 display the extracted results. Table 2 illustrates study characteristics for Ns-HypoPT studies (Humphreys, 1939; Hansted and Holst, 1952; Hinrichs, 1956; Thew and Goulston, 1962; Pisanty, 1966; Sjöberg, 1966; Greenberg et al., 1969; Hermans et al., 1969; Moshkowitz et al., 1969; Riley, 1969; Nally, 1970; Frensilli et al., 1971; Lovestedt, 1971; Assif, 1977; Pisanty and Garfunkel, 1977; Myllärniemi and Perheentupa, 1978; Lindeberg, 1979; Goepferd and Flaitz, 1981; Illum et al., 1981; Jensen et al., 1981; Nikiforuk and Fraser, 1981; Børglum Jensen et al., 1983; Harrell, 1983; Ingemarsson, 1984; Lyles et al., 1985; de Carvalho et al., 1986; Porter and Scully, 1986; Ahonen et al., 1990; Porter et al., 1992, 1995; Walls and Soames, 1993; Hershkovitz et al., 1995; Lukinmaa et al., 1996; Firth et al., 1997; Jaquez et al., 1997; Perniola et al., 1998; Fukui et al., 2000; Winer and Merke, 2000; Klingberg et al., 2002, 2005, 2007; Al-Malik, 2004; López-Jornet et al., 2005; Oberoi and Vargervik, 2005; Yang et al., 2005; da Silva Dalben et al., 2008; McGovern et al., 2008; Kelly et al., 2009; Pavlic and Waltimo-Siren, 2009; Toka et al., 2010; Wasersprung et al., 2010; Heliövaara et al., 2011; Kollios et al., 2011; Oberoi et al., 2011; Nordgarden et al., 2012; Ponranjini et al., 2012; El Batawi, 2013; Kamarthi et al., 2013; Nortjé, 2013; Ali et al., 2014; Srirangarajan et al., 2014; Laccetta et al., 2015; Matthews-Brzozowska et al., 2015; Bruserud et al., 2016; Ferre et al., 2016; Bjanid et al., 2017; Lewyllie et al., 2017; Mohsenipour et al., 2017) with subgroups A–E corresponding to the classification given in Table 1. Table 3 illustrates the oro-dental findings in Ns-HypoPT studies. Two studies (Jackson and Whyte, 1967; Kinirons and Glasgow, 1985) were not included in the tables, as they only reported on dentinal changes seen in light microscope. Table 4 illustrates study characteristics for all PHP studies (Croft et al., 1965; Ritchie, 1965; Okano et al., 1969; Glynne et al., 1972; Witkop, 1976; Myllärniemi and Perheentupa, 1978; Illum et al., 1980; Jensen et al., 1981; Nikiforuk and Fraser, 1981; Storm et al., 1985; Lagarde et al., 1989; Brown and Aaron, 1991; Cohen, 1991; Gomes et al., 2002; Goswami et al., 2009; Velez et al., 2009; Sengupta et al., 2012; Hugar et al., 2014; Reis et al., 2016; Delantoni et al., 2017; Gallacher et al., 2017) as a combined group, and Table 5 illustrates the oro-dental findings in PHP studies. The studies included were published between 1939 and 2017 (Humphreys, 1939; Lewyllie et al., 2017). The majority were case reports (52 papers) or case series (26 papers), and only nine cross-sectional and one prospective cohort study were included.
Only one of the included studies claimed the group of participants to be representative for the population studied (Ahonen et al., 1990). The number of participants with oral examination among the 88 studies included, ranged from 1 to 68 (Ahonen et al., 1990; Firth et al., 1997). The age of participants in the studies varied from 0 to 67 years. The total number of studies describing Ns-HypoPT were 68, comprising 630 patients in the five different subgroups A–E (Table 2). However, only 39 of the 309 patients in subgroup C (22q11DS) also reported having HypoPT, and 208 of the 233 patients in subgroup D (APS 1) underwent an oral examination. Out of 233 patients, only 154 had HypoPT. The total number of patients with Ns-HypoPT, who underwent an oral examination, was 603. The total number of studies describing PHP was 21, including a total of 56 patients (Table 4).
Diagnostic Criteria Used in the Publications
The studies lacked the use of international standardized criteria for the description of dental anomalies. Only few studies (n = 4) mentioned the diagnostic criteria used to assess dental anomalies, e.g., as dental opacities and enamel hypoplasia (Klingberg et al., 2002, 2007; da Silva Dalben et al., 2008; Nordgarden et al., 2012). In addition, no studies described the criteria for the distinction between impactions and retentions.
Findings of Dental Characteristics
In 603 patients with Ns-HypoPT and oral examination, the most prevalent findings were dental tissue alterations as enamel hypoplasia [n = 251 (42%)], enamel opacities [n = 115 (19%)], quantitative dental anomaly as hypodontia [n = 73 (12%)], and eruption disturbances, especially delayed eruption [n > 38 (>6%) the exact number was not specified in all the studies; Table 3]. However, only 14 of the 68 studies (21%) on Ns-HypoPT reported information on the genetic molecular diagnosis of the disease. In the studies mentioned in Table 3, a number of additional findings as cemental hyperplasia, widened periodontal ligament space, widened apical foramen, thickening of lamina dura, hyperdontia, resorptions, forced bite, as well as osteitis with normal root formation were occasionally reported (Thew and Goulston, 1962; Frensilli et al., 1971; Jensen et al., 1981; Børglum Jensen et al., 1983; Toka et al., 2010; Nordgarden et al., 2012; El Batawi, 2013; Srirangarajan et al., 2014; Lewyllie et al., 2017). Dentinal changes were described in three publications (Jackson and Whyte, 1967; Kinirons and Glasgow, 1985; Fukui et al., 2000). Kinirons and Glasgow found no gross dentinal changes in three patients. In contrast, Jackson and Whyte and Fukui and co-workers found irregularities of calcification and matrix formation in one patient, respectively.
In patients with PHP (n = 56), the most frequently reported findings were dental tissue alterations as enamel hypoplasia [n = 41 (73%)], deviation of root morphology [n>22 (>39%)], blunting of root apex [n = 21 (38%)], and eruption disturbances, especially retention [n = 14 (25%); Table 5]. Only three studies reported detailed information on genetic molecular diagnosis. In addition to findings listed in Table 5, enamel pearls, widened apical foramen, as well as ankylosed teeth were occasionally reported in a limited number of studies (Croft et al., 1965; Jensen et al., 1981; Lagarde et al., 1989; Brown and Aaron, 1991).
Calcium and phosphate metabolism is affected in Ns-HypoPT and PHP and considered of importance to tooth development (Pindborg, 1982). Many different, but sporadically-occurring, dental features were found in patients with Ns-HypoPT and PHP. The most frequently reported dental findings in patients suffering from Ns-HypoPT were enamel hypoplasia, enamel opacities, hypodontia, and various types of eruption disturbances. The most frequently reported dental findings in patients with PHP were enamel hypoplasia, eruption disturbances, and deviation of root morphology. However, the character of studies and the number of cases, providing the basis of the studies, were too small to determine relatively, which dental anomalies were having the strongest association with the two diseases.
As in the dental field, well-defined diagnostic criteria also appear to be a challenge in the medical field. IHP, a condition with unknown etiology, is classified as a subgroup of Ns-HypoPT (Table 2). However, we cannot exclude the possibility that a few (n ≤ 15) of these patients with IHP might suffer from PHP. Description of verification of Hypo-PT was lacking and the details of the medical examinations underlying the diagnosis was not fully documented in some of these publications (Lovestedt, 1971; Assif, 1977; Illum et al., 1981; Nortjé, 2013; Mohsenipour et al., 2017). The majority of the case reports are published before 1985, and molecular genetic tests were not included in these papers. One study described a patient with acute meningo-encephalitis and, therefore, they made no attempt to establish whether it was a case of PHP or IHP (Assif, 1977), but the patient was diagnosed as IHP. Nine studies out of 25 studies reporting IHP (36%) performed a test (administration of parathyroid hormone) to rule out the diagnosis of PHP (Humphreys, 1939; Hinrichs, 1956; Thew and Goulston, 1962; Pisanty, 1966; Sjöberg, 1966; Moshkowitz et al., 1969; Riley, 1969; Frensilli et al., 1971; Illum et al., 1981). Only eight out of 25 studies (32%) provided information on PTH levels (Table 4), as an indication of these patients having Ns-HypoPT, most likely 22q11DS or APS 1. Some studies of IHP reported pulp deviations and root deviations (Assif, 1977; Illum et al., 1981) with a greater frequency than reported in the other subgroups of Ns-HypoPT. From a dental point of view, this might indicate that a few patients in the IHP group instead may have suffered from PHP. Furthermore, other studies on IHP reported on enamel opacities. This dental finding, however, is only reported few times in PHP patients, but occurs with a higher frequency in Ns-HypoPT, subgroups like 22q11DS and APS 1 (Pisanty, 1966; Moshkowitz et al., 1969; Jensen et al., 1981; Kelly et al., 2009). This could indicate that some of the patients denominated as having IHP in reality could have suffered from 22q11DS or APS 1.
Teeth develop in a predictable sequence over 20 years, and formation and/or eruption of teeth can be used to estimate age up to early adulthood (AlQahtani et al., 2014). This means that disturbances in processes related to tooth development at a particular time point can cause defects (e.g., enamel opacities or enamel hypoplasia) on the tooth at different localizations. Standardized terminology and criteria for diagnosis of enamel hypoplasia and enamel opacities was not used in the majority of the included studies in the present review. In addition, there was no distinction between retention and impaction, as these words seemed to be used synonymously (Illum et al., 1981; Jensen et al., 1981; Ponranjini et al., 2012; Delantoni et al., 2017). Furthermore, standard protocol was lacking for the overall oral examination in the majority of the publications. Selective reporting and observational bias might be a risk, as case series and case reports were included.
Inaccuracies in the terminology on enamel abnormalities were noted. Enamel anomalies described as white stainings (Goswami et al., 2009), chalky white areas (Lagarde et al., 1989), or dull white in color (Ritchie, 1965) are not the characteristics of opacities only. Dental fluorosis and caries can also cause white spot lesions, which were not discussed in the publications (Ritchie, 1965; Lagarde et al., 1989; Goswami et al., 2009). In addition, negative findings were not stated in a number of studies. Hence, it was unknown if negative findings were assessed or not. Furthermore, in studies with 22q11 DS or APS 1, it was not always possible to differentiate patients diagnosed with HypoPT from those without the diagnosis. It is therefore uncertain which of the reported dental findings are in fact associated with HypoPT.
Dental findings related to Ns-HypoPT and PHP differed; e.g., blunting of root apex was reported more frequently in patients with PHP than in patients with Ns-HypoPT. PHP is often diagnosed later in life, because only type 1a has a clear phenotype, and patients often develop hypocalcemia later than patients with Ns-HypoPT do. However, it has so far not been possible to establish any correlation between enamel hypoplasia and the age of diagnosis/treatment (Reis et al., 2016). Patients with PHP may be exposed to hypocalcemia later in life than other relevant patient categories. Therefore, this could explain why the root is affected more frequently in patients with PHP compared to patients with Ns-HypoPT.
Hypocalcemia is proposed to be involved in the etiology of enamel opacities and enamel hypoplasia. Studies have shown that enamel opacities and enamel hypoplasia develop in children who suffer from hypocalcemia during the period of enamel formation (secretion, mineralization, and maturation; Stimmler et al., 1973; Nikiforuk and Fraser, 1981; Fraser and Nikiforuk, 1982; Klingberg et al., 2005; Kelly et al., 2009). However, enamel opacities and hypoplasia are reported more often in the permanent than in the primary dentition (Nordgarden et al., 2012). Stimmler et al. (1973) found that enamel defects occurred in postnatally developed teeth of children who suffered from neonatal tetany caused by hypocalcemia. Nikiforuk and Fraser (1981) support this finding. They found that all patients with enamel hypoplasia had hypocalcemia. Moreover, they found no correlation between enamel hypoplasia and plasma phosphate concentration. They hypothesized that enamel hypoplasia is a more sensitive indicator of hypocalcaemia than the classic neurological indices (i.e., tetany and convulsion). In addition, an animal study showed that rats with thyro-parathyrodectomi-induced hypocalcemia developed incisors with enamel hypoplasia (Chardi et al., 1998). However, normal tooth formation may not only depend on calcium metabolism. In mice, GCM2 and PTH, which are genes associated with Ns-HypoPT and PHP, are not expressed during cap stage of tooth germs formation. In contrast, CaSR and AIRE are moderately expressed (higher in lower molars than in upper molars) and TBX1, GNAS and STX16 are highly expressed during tooth germs formation in mouse (Laugel-Haushalter et al., 2013). A direct effect during tooth development in humans mediated via Tbx1, GNAS, STX16, CASR, and AIRE is therefore possible. The etiology of enamel defects in patients suffering from APS 1 remains unclear (Perniola et al., 1998). Porter et al. (1995) reported an association of enamel defects with HypoPT, but Ahonen et al. (1990) suggested that there was no such association.
PTH receptor 1, PTHR1, a G protein-coupled receptor for parathyroid hormone and parathyroid hormone-like mutations, has shown to cause primary failure of tooth eruption (Decker et al., 2008). Failure of tooth eruption is also seen in Ns-HypoPT and patients with PHP. Primary failure of eruption is characterized by posterior rather than anterior tooth involvement; however, this is not the pattern seen in Ns-HypoPT and PHP. The etiology of failure of eruption in Ns-HypoPT and PHP must, therefore, be hypothesized to be different from that related to PTHR1 mutations.
Worldwide interest in the association between Ns-HypoPT/PHP and dental findings is seen, as a substantial amount of the studies were performed in Asia, North and South America, and Europe. Most studies included both clinical and radiographic dental findings, which could be considered a strength. However, studies used different methods for the description of the patients, e.g., one study concerning IHP and one concerning PHP described dental findings based on only few X-rays (Lovestedt, 1971; Witkop, 1976), and a study on 22q11DS described dental findings based only on 38 exfoliated teeth from 15 different patients (Klingberg et al., 2005). Consequently, these studies did not include findings of teeth other than those that had been exfoliated or examined by radiographic examination. Hence, it is difficult to draw firm conclusions and to provide a full overview of the topic based on the available publications at present time.
In conclusion, the findings of the present review indicate a high prevalence of enamel hypoplasia and enamel opacities in patients suffering from Ns-HypoPT, and a high prevalence of enamel hypoplasia and root deviation in patients with PHP. None of the studies included in the present review were classified as high-quality studies; therefore, the results have to be interpreted cautiously. This confirms the need for further well-designed studies, for example, larger multicenter studies with identical shared protocol and definition of the diagnostic criteria as a groundwork for an identical and systematic collection of dental findings in patients with rare diseases as Ns-HypoPT and PHP.
DH developed the idea of the manuscript. All authors contributed to design. JH established the literature search string with help from DH, HG. JH extracted data from publications. JH, LU, HG, and DH contributed to analysis and interpretation of data. JH wrote the first draft of the manuscript. All authors contributed to manuscript revision, read and approved the submitted version.
This work was supported by a grant from the Danish Dental Association [NA].
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The reviewer ELN and handling Editor declared their shared affiliation.
We acknowledge the research librarian Janne Lytoft Simonsen (JLS) at The Royal Danish Library, Aarhus University, Aarhus, Denmark for her kind help with the literature search. We also acknowledge Virginie Laugel-Haushalter at Laboratoire de Génétique Médicale, INSERM UMRS_1112, Institut de Génétique Médicale d'Alsace, FMTS, Université de Strasbourg, Strasbourg, France, who helped to gather information about the Gene Expression in tooth formation in mouse.
Ahonen, P., Myllärniemi, S., Sipilä, I., and Perheentupa, J. (1990). Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N. Engl. J. Med. 322, 1829–1836. doi: 10.1056/NEJM199006283222601
Ali, M. Y., Rashiduzzaman, H. M., Masud, M., Wadud, M. A., Quadir, S., Fattah, S. K. A., et al. (2014). A case report on autoimmune polyendocrine syndrometype 1. J. Med. 15, 98–101. doi: 10.3329/jom.v15i1.19886
AlQahtani, S. J., Hector, M. P., and Liversidge, H. M. (2014). Accuracy of dental age estimation charts: Schour and Massler, Ubelaker and the London Atlas. Am. J. Phys. Anthropol. 154, 70–78. doi: 10.1002/ajpa.22473
Bilezikian, J. P., Khan, A., Potts, J. T. Jr., Brandi, M. L., Clarke, B. L., Shoback, D., et al. (2011). Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J. Bone Miner. Res. 26, 2317–2337. doi: 10.1002/jbmr.483
Bjanid, O., Adamczyk, P., Stojewśka, M., Roszkowska-Bjanid, D., Paszyna-Grzeskowiak, M., Jedzura, A., et al. (2017). Rare case of nephrocalcinosis in a 14-year-old girl: questions. Pediatr. Nephrol. 32, 607–608. doi: 10.1007/s00467-016-3434-1
Bruserud, ø., Oftedal, B. E., Landegren, N., Erichsen, M. M., Bratland, E., Lima, K., et al. (2016). A longitudinal follow-up of autoimmune polyendocrine syndrome type 1. J. Clin. Endocrinol. Metab. 101, 2975–2983. doi: 10.1210/jc.2016-1821
Chardi, H., Acevedo, A. C., and Risnes, S. (1998). SEM study of the development of rat incisor enamel hypoplasia under hypocalcemia induced by thyro-parathyroidectomy. Connect. Tissue Res. 39, 157–164. doi: 10.3109/03008209809023922
da Silva Dalben, G., Richieri-Costa, A., and de Assis Taveira, L. A. (2008). Tooth abnormalities and soft tissue changes in patients with velocardiofacial syndrome. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 106, e46–e51. doi: 10.1016/j.tripleo.2008.04.019
Decker, E., Stellzig-Eisenhauer, A., Fiebig, B. S., Rau, C., Kress, W., Saar, K., et al. (2008). PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Am. J. Hum. Genet. 83, 781–786. doi: 10.1016/j.ajhg.2008.11.006
Delantoni, A., Lyroudia, K., Rafailidis, V., and Chryssogonidis, I. (2017). Pseudohypoparathyroidism diagnosed in adulthood: maxillofacial clinical and radiographic findings. Oral Radiol. 33, 153–156. doi: 10.1007/s11282-016-0254-8
Ebell, M. H., Siwek, J., Weiss, B. D., Woolf, S. H., Susman, J., Ewigman, B., et al. (2004). Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. Am. Fam. Phys. 69, 548–556. doi: 10.3122/jabfm.17.1.59
Ferre, E. M., Rose, S. R., Rosenzweig, S. D., Burbelo, P. D., Romito, K. R., Niemela, J. E., et al. (2016). Redefined clinical features and diagnostic criteria in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. JCI Insight 1:e88782. doi: 10.1172/jci.insight.88782
Firth, N. A., O'Grady, J. F., and Reade, P. C. (1997). Oral squamous cell carcinoma in a young person with candidosis endocrinopathy syndrome: a case report. Int. J. Oral Maxillofac. Surg. 26, 42–44. doi: 10.1016/S0901-5027(97)80845-4
Fukui, N., Amano, A., Akiyama, S., Daikoku, H., Wakisaka, S., and Morisaki, I. (2000). Oral findings in DiGeorge syndrome: clinical features and histologic study of primary teeth. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 89, 208–215. doi: 10.1067/moe.2000.103884
Gallacher, A. A., Pemberton, M. N., and Waring, D. T. (2017). The dental manifestations and orthodontic implications of hypoparathyroidism in childhood. J. Orthod. 45, 46–50. doi: 10.1080/14653125.2017.1406685
Gao, S., Moreno, M., Eliason, S., Cao, H., Li, X., Yu, W., et al. (2015). TBX1 protein interactions and microRNA-96-5p regulation controls cell proliferation during craniofacial and dental development: implications for 22q11.2 deletion syndrome. Hum. Mol. Genet. 24, 2330–2348. doi: 10.1093/hmg/ddu750
Glynne, A., Hunter, I. P., and Thomson, J. A. (1972). Pseudohypoparathyroidism with paradoxical increase in hypocalcaemic seizures due to long-term anticonvulsant therapy. Postgrad. Med. J. 48, 632–636. doi: 10.1136/pgmj.48.564.632
Gomes, M. F., Camargo, A. M., Sampaio, T. A., Graziozi, M. A., and Armond, M. C. (2002). Oral manifestations of Albright hereditary osteodystrophy: a case report. Rev. Hosp. Clin. Fac. Med. Sao Paulo 57, 161–166. doi: 10.1590/S0041-87812002000400006
Goswami, M., Verma, M., Singh, A., Grewal, H., and Kumar, G. (2009). Albright hereditary osteodystrophy: a rare case report. J. Indian Soc. Pedod. Prev. Dent. 27, 184–188. doi: 10.4103/0970-4388.57101
Greenberg, M. S., Brightman, V. J., Lynch, M. A., and Ship, I. I. (1969). Idiopathic hypoparathyroidism, chronic candidiasis, and dental hypoplasia. Oral Surg. Oral Med. Oral Pathol. 28, 42–53. doi: 10.1016/0030-4220(69)90192-3
Heliövaara, A., Rantanen, I., and Arte, S. (2011). Dental development and tooth agenesis in children with velocardiofacial syndrome. Int. J. Paediatr. Dent. 21, 446–450. doi: 10.1111/j.1365-263X.2011.01148.x
Hermans, P. E., Ulrich, J. A., and Markowitz, H. (1969). Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria. Am. J. Med. 47, 503–519. doi: 10.1016/0002-9343(69)90181-8
Hershkovitz, E., Shalitin, S., Levy, J., Leiberman, E., Weinshtock, A., Varsano, I., et al. (1995). The new syndrome of congenital hypoparathyroidism associated with dysmorphism, growth retardation, and developmental delay–a report of six patients. Isr. J. Med. Sci. 31, 293–297.
Hospital, T. O. (2014). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Available online at: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp (Accessed November 16, 2017).
Illum, F., Dupont, E., Jensen, S. B., Petersen, O. F., Alsbirk, K. E., Rømer, F. K., et al. (1981). [Idiopathic hypoparathyroidism. Recent diagnostic and therapeutic aspects]. Ugeskr. Laeg. 143, 1528–1532.
Jaquez, M., Driscoll, D. A., Li, M., Emanuel, B. S., Hernandez, I., Jaquez, F., et al. (1997). Unbalanced 15;22 translocation in a patient with manifestations of DiGeorge and velocardiofacial syndrome. Am. J. Med. Genet. 70, 6–10. doi: 10.1002/(SICI)1096-8628(19970502)70:1<6::AID-AJMG>3.0.CO;2-Z
Kelly, A., Pomarico, L., and de Souza, I. P. (2009). Cessation of dental development in a child with idiopathic hypoparathyroidism: a 5-year follow-up. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 107, 673–677. doi: 10.1016/j.tripleo.2008.11.017
Klingberg, G., Dietz, W., Oskarsdóttir, S., Odelius, H., Gelander, L., and Noren, J. G. (2005). Morphological appearance and chemical composition of enamel in primary teeth from patients with 22q11 deletion syndrome. Eur. J. Oral Sci. 113, 303–311. doi: 10.1111/j.1600-0722.2005.00223.x
Klingberg, G., Lingström, P., Oskarsdottir, S., Friman, V., Bohman, E., and Carlen, A. (2007). Caries-related saliva properties in individuals with 22q11 deletion syndrome. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 103, 497–504. doi: 10.1016/j.tripleo.2006.09.018
Kollios, K., Tsolaki, A., Antachopoulos, C., Moix, I., Morris, M. A., Papadopoulou, M., et al. (2011). Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome (APECED) due to AIRET16M mutation in a consanguineous Greek girl. J. Pediatr. Endocrinol. Metab. 24, 599–601. doi: 10.1515/jpem.2011.012
Laccetta, G., Toschi, B., Fogli, A., Bertini, V., Valetto, A., and Consolini, R. (2015). Clinical phenotype of DiGeorge syndrome with negative genetic tests: a case of DiGeorge-like syndrome? Case Rep. Pediatr. 2015:938074. doi: 10.1155/2015/938074
Laugel-Haushalter, V., Paschaki, M., Thibault-Carpentier, C., Dembelé, D., Dollé, P., and Bloch-Zupan, A. (2013). Molars and incisors: show your microarray IDs. BMC Res. Notes 6:113. doi: 10.1186/1756-0500-6-113
Lewyllie, A., Roosenboom, J., Indencleef, K., Claes, P., Swillen, A., Devriendt, K., et al. (2017). A comprehensive craniofacial study of 22q11.2 deletion syndrome. J. Dent. Res. 96, 1386–1391. doi: 10.1177/0022034517720630
Lukinmaa, P. L., Waltimo, J., and Pirinen, S. (1996). Microanatomy of the dental enamel in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): report of three cases. J. Craniofac. Genet. Dev. Biol. 16, 174–181.
Lyles, K. W., Burkes, E. J. Jr., McNamara, C. R., Harrelson, J. M., Pickett, J. P., and Drezner, M. K. (1985). The concurrence of hypoparathyroidism provides new insights to the pathophysiology of X-linked hypophosphatemic rickets. J. Clin. Endocrinol. Metab. 60, 711–717. doi: 10.1210/jcem-60-4-711
Matthews-Brzozowska, T., Baranowska, J., Roginski, P., Obersztyn, E., and Cudziło, D. (2015). Malocclusions and craniofacial anomalies in a child with velo-cardio-facial syndrome. Dev. Period Med. 19, 490–495.
McGovern, E., Fleming, P., Costigan, C., Dominguez, M., Coleman, D. C., and Nunn, J. (2008). Oral health in Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). Eur. Arch. Paediatr. Dent. 9, 236–244. doi: 10.1007/BF03262642
Medicin, C. F. E.-B. (2017). OCEBM Levels of Evidence. University of Oxford. Available online at: http://www.cebm.net/ocebm-levels-of-evidence/ (Accessed November 16, 2017).
Mohsenipour, R., Mohebbi, A., Rostami, P., Fallahi, A., and Rahmani, P. (2017). Prevalence of dental abnormalities in different calcium metabolism disorders in a group of Iranian children. Biomed. Res. 28, 6757–6762.
Myllärniemi, S., and Perheentupa, J. (1978). Oral findings in the autoimmune polyendocrinopathy-candidosis syndrome (APECS) and other forms of hypoparathyroidism. Oral Surg. Oral Med. Oral Pathol. 45, 721–729. doi: 10.1016/0030-4220(78)90147-0
Nikiforuk, G., and Fraser, D. (1979). Etiology of enamel hypoplasia and interglobular dentin: the roles of Hypocalcemia and Hypophosphatemia. Metab. Bone Dis. Related Res. 2, 17–23. doi: 10.1016/0221-8747(79)90014-6
Nordgarden, H., Lima, K., Skogedal, N., Følling, I., Storhaug, K., and Abrahamsen, T. G. (2012). Dental developmental disturbances in 50 individuals with the 22q11.2 deletion syndrome; relation to medical conditions? Acta Odontol. Scand. 70, 194–201. doi: 10.3109/00016357.2011.629624
Okano, K., Fujita, T., Orimo, H., and Yoshikawa, M. (1969). A case of pseudohypoparathyroidism with increased bone turnover and demineralization. Endocrinol. Jpn. 16, 423–431. doi: 10.1507/endocrj1954.16.423
Pavlic, A., and Waltimo-Siren, J. (2009). Clinical and microstructural aberrations of enamel of deciduous and permanent teeth in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Arch. Oral Biol. 54, 658–665. doi: 10.1016/j.archoralbio.2009.03.009
Perniola, R., Tamborrino, G., Marsigliante, S., and De Rinaldis, C. (1998). Assessment of enamel hypoplasia in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J. Oral Pathol. Med. 27, 278–282. doi: 10.1111/j.1600-0714.1998.tb01956.x
Porter, S. R., Haria, S., Scully, C., and Richards, A. (1992). Chronic candidiasis, enamel hypoplasia, and pigmentary anomalies. Oral Surg. Oral Med. Oral Pathol. 74, 312–314. doi: 10.1016/0030-4220(92)90065-X
Reis, M. T., Matias, D. T., Faria, M. E., and Martin, R. M. (2016). Failure of tooth eruption and brachydactyly in pseudohypoparathyroidism are not related to plasma parathyroid hormone-related protein levels. Bone 85, 138–141. doi: 10.1016/j.bone.2016.02.002
Sengupta, S., Ravindran, R. D., Kannusamy, V., and Tamrakar, V. (2012). Bilateral simultaneous disc edema and cataract associated with albright hereditary osteodystrophy. Middle East Afr. J. Ophthalmol. 19, 166–168. doi: 10.4103/0974-9233.92136
Sjöberg, K. H. (1966). Moniliasis–an internal disease? Three cases of idiopathic hypoparathyroidism with moniliasis, steatorrhea, primary amenorrhea and pernicious anemia. Acta Med. Scand. 179, 157–166. doi: 10.1111/j.0954-6820.1966.tb05443.x
Srirangarajan, S., Satyanarayan, A., Ravindra, S., and Thakur, S. (2014). Dental manifestation of primary idiopathic hypoparathyroidism. J. Indian Soc. Periodontol. 18, 524–526. doi: 10.4103/0972-124X.138755
Velez, I., Bond, M., Ellen, S., Ede-Nichols, D., Larumbe, J., Oramas, V., et al. (2009). Hereditary osteodystrophy with multiple hormone resistance–a case report. J. Clin. Pediatr. Dent. 34, 67–69. doi: 10.17796/jcpd.34.1.33017umx4n144285
Wasersprung, D., Platis, C. M., Cohen, S., Kaczko, L., Zunser, I., Peretz, B., et al. (2010). Case report: Sanjad–Sakati syndrome: dental findings and treatment. Eur. Arch. Paediatr. Dent. 11, 151–154. doi: 10.1007/BF03262733
Keywords: hypoparathyroidism, pseudohypoparathyroidism, 22q11 deletion syndrome, dental anomalies, enamel hypoplasia
Citation: Hejlesen J, Underbjerg L, Gjørup H, Bloch-Zupan A, Sikjaer T, Rejnmark L and Haubek D (2018) Dental Findings in Patients With Non-surgical Hypoparathyroidism and Pseudohypoparathyroidism: A Systematic Review. .Front. Physiol. 9:701. doi: 10.3389/fphys.2018.00701
Received: 20 March 2018; Accepted: 18 May 2018;
Published: 19 June 2018.
Edited by:Catherine Chaussain, Université Paris Descartes, France
Reviewed by:Ana Carolina Acevedo, University of Brasília, Brazil
Elvire Le Norcy, Université Paris Descartes, France
Copyright © 2018 Hejlesen, Underbjerg, Gjørup, Bloch-Zupan, Sikjaer, Rejnmark and Haubek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Dorte Haubek, email@example.com