Impact Factor 3.201 | CiteScore 3.22
More on impact ›

Systematic Review ARTICLE

Front. Physiol., 20 July 2018 | https://doi.org/10.3389/fphys.2018.00946

Replicability of Physical Exercise Interventions in Lung Transplant Recipients; A Systematic Review

  • 1Directorate of Research and Education, Physiotherapy & Occupational Therapy Research Center, University Hospital Zurich, Zurich, Switzerland
  • 2Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland
  • 3Department of Physiotherapy and Occupational Therapy, University Hospital Zurich, Zurich, Switzerland
  • 4Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden

Introduction: This systematic review aimed to assess the replicability of physical exercise interventions in lung transplantation patients. For replicability we focused on (1) the description of training principles, (2) the description of FITT components and adherence to the interventions, (3) the amount of detailed information given on the physical exercise intervention, and (4) reporting the methodological quality of the included works.

Methods: Relevant databases (Medline-Ovid, EMBASE, CINAHL, PsychInfo, Cochrane Library) were searched. Author dyads selected and systematically analyzed the included studies independent from each other. A purpose developed checklist was used to assess the details of the exercise interventions and their methodological quality.

Results: From the seven included manuscripts, three described resistance training, one endurance, and three combined training approaches. All manuscripts reported specificity and initial values, six manuscripts mention progression and overload. The exercise principle reversibility was reported once and diminishing returns was not reported at all. All studies reported the type of exercise, three studies reported intensity and one study reported time for training. Not any study completely reported frequency or described adherence to the intervention. Lack of detailed reporting was identified as the cause for murky description of the interventions. The highest score for intervention description was 5 of possible 12 items.

Conclusions: Replicability of many exercise interventions in LTX is not warranted due too poor descriptions of important items related to training. In particular there were insufficiently detailed reporting of training principles and FITT components in programs developed for LTX. Future interventions that aim to train LTX patients should spent effort in writing reports in which the intervention is detailed to such an extent that full replicability in clinical settings can be guaranteed.

Introduction

Background

Survival and health related quality-of-life in patients with end stage pulmonary disease is expected to improve following lung transplantation (LTX) (Hatt et al., 2017). Both in early (less than 1 year) and in late (more than 1 year) LTX patients it seems feasible, safe, and effective to perform physical exercise (PE) following transplantation (Wickerson et al., 2010; Didsbury et al., 2013; Langer, 2015; Wallen et al., 2016). When LTX-exercisers and non-exercisers are compared, some evidence is available supporting that structured PE programs improve maximal exercise capacity, physical function, muscle strength, and bone mineral density (BMD) (Wickerson et al., 2010; Langer et al., 2012) and, thus, favors exercise regarding amelioration of physical and functional task capacities. Such improvements seem especially apparent in patients perceiving their physical functioning as low (Wickerson et al., 2015).

Evidence summaries, however, showed much variability regarding the effects different training programs have on the selected training outcomes for LTX patients. This seems to indicate that not all exercise programs for LTX patients are equally effective (Wickerson et al., 2010; Didsbury et al., 2013; Wallen et al., 2016). These differences in effect might be due to the confusion between exercise and physical activity (Caspersen et al., 1985). Physical activity is “any bodily movement produced by skeletal muscle resulting in energy expenditure” whereas exercise is defined as “a planned, structured, and repetitive subset of physical activity with an identifiable aim to improve or maintain physical fitness” (Caspersen et al., 1985). For clinicians selection and replication of successful exercise programs is important. In addition to evaluating and judging the results of systematic reviews clinicians should, therefore, be able and identify replicable (successful) interventions for the translation of useful interventions in clinical settings (Hoffmann et al., 2014).

Researchers wanting to replicate successful intervention research and clinicians wanting to apply these interventions in their practice both need detailed descriptions of the applied procedures in the intervention program. However, many published intervention research fails to conform to requirements that would guarantee full replicability (Hoffmann et al., 2014). When reporting the results of a PE program, it is important to document the core principles of the used training (Campbell et al., 2012; Winters-Stone et al., 2014) and how these were considered for the population under investigation. These principles of PE are specificity, overload, progression, initial values, reversibility, and diminishing returns; see for a more detailed description (Hoffman, 2002). When designing a PE intervention, adhering to the principles of PE ensures that an appropriate dose and type of exercise can be applied to accomplish a pre-determined training goal; e.g., set goals may relate to endurance, strength and/or physical function. Furthermore, it is of relevance to report the Frequency, Intensity, Time and Type (FITT) of the PE intervention. Only if PE training programs are documented in sufficient detail, their replication can be warranted, and clinicians and researchers are enabled to apply these effective interventions (Hoffmann et al., 2014).

For exercise interventions to be replicable there should at least be reporting of the FITT components (Ammann et al., 2014; Baschung Pfister et al., 2015). This holds true for both more traditional forms of exercise and for innovative training approaches where for example novel technology is used; e.g., exergame based training (Eggenberger et al., 2015; Knols et al., 2016). Randomized controlled trials (RCTs) theoretically provide the best evidence regarding the effectiveness of PE interventions; however, inadequate methodological approaches may overstate treatment effects and bias results (Schulz et al., 2010; Baschung Pfister et al., 2015). Although there are several reviews that describe the outcomes of PE in LTX-patients, to the best of our knowledge there is no overview assessing how well such interventions may be replicated.

Objectives

This systematic review aimed to assess the replicability of physical exercise programs reported in RCTs investigating the use of PE interventions in LTX patients. To assess replicability we focused on (1) the description of exercise principles, (2) the description of FITT components and adherence to the interventions, (3) the amount of detailed information given on the PE intervention and, (4) reporting the methodological quality of the included works.

Methods

Research Protocol

This systematic review was performed using a structured study protocol guiding the search strategy, the selection of the studies, and the abridgement of data entry forms for the analysis, similar as in earlier reviews (Ammann et al., 2014; Knols et al., 2016).

Search Strategy and Data Sources

A librarian experienced in developing searches for systematic reviews (MG; Medical Library of the University of Zurich) developed a purpose-adjusted professional search strategy. The search period covered all years from the start of the medical databases to November 2016, and covered Medline-Ovid, EMBASE, Cochrane Library (PubMed), CINAHL, and PsycInfo. Searches were undertaken using MeSH headings including the following main terms: Organ transplantation, lung transplantation, heart-lung transplantation, lung disease, pulmonary heart disease, thoracic surgery, transplant recipients, chronic obstructive pulmonary disease (COPD), cystic fibrosis, pulmonary hypertension, idiopathic pulmonary fibrosis, lymphangioleiomyomatosis, physical therapy modalities, rehabilitation, exercise movement techniques, exercise therapy, resistance training, physical endurance, physical fitness, motor activity, exercise, perioperative care, balance test, physical activity measures, questionnaire, pedometers or accelerometers, health related quality of life, physical endurance, physical fitness, dyspnea: Borg scale, spirometry, FEV1, peak flow, bone mineral density, range of motion. The following free text words were used: Inspiratory muscle training, exergame or exergaming, robot assisted, high intensity interval training (HIIT), muscle strength, quadriceps and handgrip force, maximal oxygen consumption (VO2max), peak power output (VO2peak), (an-)aerobic threshold, days in hospital, mortality or morbidity, upper extremity endurance capacity, gait speed, sit-to-stand-test, short physical performance battery, timed up and go, 6 min walking test. A detailed description of the search per database is provided in the supplementary file.

Furthermore, from December 2016 to December 2017, the databases were checked monthly by RHK for new publications. The references of all eligible articles and related reviews, as well as recent conference proceedings, were searched and checked through hand searching by NF and RHK. For reporting we used the PRISMA guidelines (Liberati et al., 2009).

Comparators and Interventions

RCTs that contained descriptions of (1) physical exercise training, (2) focused on LTX recipients (including children and adult populations), and (3) described interventions aiming to ameliorate physical function and/or psychosocial outcomes (primary or secondary quantified outcome) were included in the analyses. Studies that included lung transplant candidates that were performing training while being on the LTX waiting list, that included patients with a combined heart and lung transplantation, and were written in non-English languages were excluded.

Study Selection and Data Extraction

Ordaining manuscript eligibility for inclusion was done by two individuals (NF & RHK) (Kamper et al., 2015) after duplicate removal from the search results. NF & RHK screened all the retrieved citations independent from each other and they, after this, met for a consensus discussion. In this discussion manuscripts where disagreement surrounding eligibility was apparent were reviewed together. In case of remaining disagreement between the reviewers EDB was consulted for a final decision regarding in-/exclusion.

Data Extraction and Analysis of the Studies

NF created purpose-designed data collection sheets commensurable with approaches used in previous systematic reviews (Ammann et al., 2014; Baschung Pfister et al., 2015; Knols et al., 2016) (Table 1).

TABLE 1
www.frontiersin.org

Table 1. Overview of the included studies.

Description of Exercise Principles

The assessment and grading of exercise principles (Hoffman, 2002) reporting (Table 2) meant that one point was given for those cases where a clear description of a training principle was identifiable. Absent or unclear descriptions implied giving zero points for the concerned item.

TABLE 2
www.frontiersin.org

Table 2. Description of reporting of the principles of exercise training.

Description of the FITT Exercise Program Components

Similar as in commensurable reviews, where FITT components for cardiovascular and resistive exercise were summarized (Knols et al., 2016), characteristics of exercise sessions, episodes, or bouts per week (Hoffman, 2002) were collected. This included descriptions of recovery time following training, both for exercise and control groups where applicable (Bishop et al., 2008). Intensity refers to the amount of work performed or to the magnitude of effort required performing an activity or exercise. Time, length, or duration in which an activity or exercise is performed was captured; e.g., expressed in minutes, together with information about the exercise type (Hoffman, 2002; Ammann et al., 2014; Baschung Pfister et al., 2015). Registering of FITT component and patients' adherence to the intervention was done with two rating categories by two individuals (NF & DK); “reported” = 1 point, “not or unclear/inconsistently reported” = 0 points (Table 3). FITT components were assumed to be mentioned on two occasions within a manuscript; once while the planned training program was detailed, and the second time in the Results section of a manuscript to cover aspects of adherence to the training plan (Table 3).

TABLE 3
www.frontiersin.org

Table 3. Reporting of planned FITT (gray) and adherence FITT components (white).

Description of the Intervention Details

A purpose developed guide and checklist was exerted to monitor intervention details (Hoffmann et al., 2014). For each single item on the checklist three rating categories were used. Rating was performed by NF and DK, independent from each other, as either “reported,” “unclear or inconsistently reported,” or “not reported” (Table 4).

TABLE 4
www.frontiersin.org

Table 4. Description of the intervention details (TIDieR- Checklist).

Description and Rating of Study Quality

A purpose developed checklist for study quality determination (Downs and Black, 1998) was applied by NF and AM to the critique of studies included in this review. Both performed the ratings independent from each other. “The scoring of the last item (“study power”) was modified from a 0–5 scale to a 0–1 scale, where 1 was scored when the authors reported whether and how they determined their sample size a priori (Schoene et al., 2014). One was scored if a power calculation or sample size calculation was present; zero was scored if there was no power calculation, sample size calculation, or justification whether the number of subjects in the study at hand was appropriate. Items 4 (“description of the intervention”) and 19 (“compliance with the intervention”) were scored “yes” if all FITT components were described in the methods and results for the intervention and the control group (if active at all), respectively. According to other recommendations (Kamper et al., 2015; Moseley et al., 2015), we scored item 26 (“losses to follow-up”) “yes” if the dropout rate was less than 15 percent or if an intention-to-treat analysis was conducted. The score from this modified version ranged from 0 to 28, with a higher score indicating higher methodological quality”. (Knols et al., 2016) (Table 5).

TABLE 5
www.frontiersin.org

Table 5. Downs and black methodological quality list.

Data Analyses

Benchmarks of Landis and Koch (1977) were used for the calculation and interpretation of between rater agreements (percentage agreement & Cohen's kappa, respectively). The categories were poor (0), slight (0.1–0.20), fair (0.21–0.40), moderate (0.41–0.60), substantial (0.61–0.80), and almost perfect (0.81–1.0) agreement (Landis and Koch, 1977). The reporting items of this systematic review follow the PRISMA statement (Liberati et al., 2009; Moher et al., 2009; Knols et al., 2016). Cohens d effect sizes (ES) were calculated immediately after the end of the PE program in case appropriate (Field, 2014).

To enhance rating consistency two meetings were organized to gear different raters to using the same approach and extract exercise principles, FITT components and adherence information, together with a standardized description of intervention items and methodological quality. In case of disagreement, RHK served as a referee in the familiarization session.

Results

Study Selection and Characteristics

The systematic search up to November 2016 provided 1397 citations. Following deduplication, 1070 hits remained. From these, 1055 titles failed meeting the inclusion criteria and were, thus, excluded. Full texts of 15 manuscripts were retrieved and screened. Six studies were at the end available for inclusion. Figure 1 presents the search summary and shows one study could be added following hand searching. The included studies were published from 2003 to 2017. Sample sizes varied between 16 and 80 patients. All studies included adult patients with their age ranging between 45 and 68 years. Altogether, 369 patients were included in the selected articles, 183 females and 186 males. Two studies were performed in Northern America (Mitchell et al., 2003; Braith et al., 2007), three in Europe (Ihle et al., 2011; Langer et al., 2012; Gloeckl et al., 2015) and two in Australia (Fuller et al., 2017a,b). The duration of the PE program in the studies varied between 1 (Gloeckl et al., 2015) and 6 months (Mitchell et al., 2003; Braith et al., 2007; Fuller et al., 2017b). One study of Fuller and colleagues evaluated the effect of a shorter (7 wks.) vs. a longer period (14 wks.) of PE (Fuller et al., 2017a) and another the effect of a supervised vs. a non-supervised exercise group (Fuller et al., 2017b). Two studies reported the effect of resistive strength exercise (Mitchell et al., 2003; Braith et al., 2007), one study the effect of endurance exercise (Langer et al., 2012) and four studies the effects of combined forms of PE (Ihle et al., 2011; Gloeckl et al., 2015; Fuller et al., 2017a,b).

FIGURE 1
www.frontiersin.org

Figure 1. Flowchart of the systematic review. RCT, randomized controlled trial; LTX Lungtransplantation.

Significant between-groups differences were reported in 5 RCTs for preservation of lumbar bone mineral density (BMD), quadriceps strength, walking time, walking distance, peak work rate, bodily pain VAS /Sf-36, and less pain medication intake (paracetamol) (Mitchell et al., 2003; Braith et al., 2007; Langer et al., 2012; Gloeckl et al., 2015; Fuller et al., 2017b). Conversely, three studies did not report significant between group differences for the primary outcomes 6 MWT, quadriceps and hamstrings strength, exercise capacity and self-reported quality of life (Ihle et al., 2011; Fuller et al., 2017a,b) (Table 1). Effect sizes (Cohens d) (Mitchell et al., 2003; Braith et al., 2007) for significant p-values were calculated directly after PE for the outcomes BMD of the lumbar Vertebrae L2-L3 (r = 0.52) (Mitchell et al., 2003), and for BMD as a combination of alendronate &PE training (r = 1.09) (Braith et al., 2007). Effect sizes for absolute isometric lumbar extensor strength values after PE training at 0 degrees were (r = 0.27), 12 degrees (r = 0.07), 24 (r = 0.18), 36 (r = −0.10), 48 (r = −0.08), 60 (r = −0.21), and 72 (r = −0.04) degrees (Mitchell et al., 2003). ES for walking (min /day), movement intensity, daily steps, quadriceps force and 6 Minute Walking Distance (6 MWD) were 0.77, 2.05, 0.92, 1.16, and 0.99, respectively (Langer et al., 2012). The ES for 6 MWD in the study of Gloeckl et al. (2015) was 0.54 and 0.38 for peak work rate (Table 1). Finally, the ES for decreased bodily pain after supervised training was 1.13.

Synthesized Findings Exercise Principles

The Exercise Principles “specificity” and “initial values” were identifiable and reported in all seven studies (Mitchell et al., 2003; Braith et al., 2007; Ihle et al., 2011; Langer et al., 2012; Gloeckl et al., 2015; Fuller et al., 2017a,b), six of seven studies reported the “progression” and “overload” (Mitchell et al., 2003; Braith et al., 2007; Langer et al., 2012; Gloeckl et al., 2015; Fuller et al., 2017a,b), and the principle “reversibility” was reported only once (Fuller et al., 2017b). “Diminishing returns” was not identified in any study (Table 2).

Reporting of FITT components is recapitulated in Table 3. The mean/median of the mentioning of these components was 2 (range 0–7). “Frequency” was described in none of the studies. Four studies reported training intensity (Mitchell et al., 2003; Braith et al., 2007; Langer et al., 2012; Fuller et al., 2017b). One study reported “time” (Langer et al., 2012), and all seven studies reported “type” of exercise (Mitchell et al., 2003; Braith et al., 2007; Ihle et al., 2011; Langer et al., 2012; Gloeckl et al., 2015; Fuller et al., 2017a,b). All RCTs described 3 or less components. Whether the planned training was feasible for the patient populations; e.g., by detailing aspects of adherence to training based on the FITT components, was reported in none of the seven studies (Table 3). Agreement between raters for these two rating categories (expressed through kappa values) was 0.5 (95%CI 0.3–0.7).

Table 4 expresses the results following assessment of the studies with the purpose developed guide and checklist for monitoring intervention details (Hoffmann et al., 2014). Two to five (median three) items were mentioned in the studies, ranging between 0 and 7 items mentioned for the individual studies (median 1.5). The interrater agreement (kappa) was 0.7 (95%CI 0.5–0.8).

Methodological Quality

Methodological flaws in relation to the transparency of reporting of the PE interventions were failure of detailed reporting of the exercise program (item 4), the blinding of the treatment groups (item 14), the proportion of those wo agreed in the trials (item 12), and adjustment of adherence in the exercise program (item 19). The overall methodological quality, expressed as a percentage (Downs and Black, 1998) in Table 5, was 60.7% (median 64.3%) and resulted in an “moderate to substantial” inter-rater agreement (kappa) of 0.7 (95% CI 0.6–0.8).

Discussion

The aim of this systematic review was to evaluate the replicability of exercise interventions for LTX patients by assessing the details of the description of these interventions in randomized control studies. The results showed that PE training components were not described with a level of detail that would guarantee full replicability for researchers wanting to replicate the intervention or for clinicians wanting to implement successful interventions for their patients. Based on the partially sparse descriptions clinicians cannot be confident in replicating the exercise programs such that similar effects are attained for their patients. There was a lack of detail regarding the reporting of items that would be essential for good replicability; e.g., giving sufficient information about the frequency of training, the intensity needed to receive the results, the time needed for one training and the exercise type that has to be applied (Knols et al., 2016).

The identification of these vestigial descriptions of intervention plans that prevent program replication with confidence for both researchers and practitioners is an important uncovered research gap. Although all seven trials reported which type of training was used, none of the studies provided reports on how well patients were able to comply with their prescribed training. Similar results were observed for the description of other important aspects of training components. This is a point of concern because a lack of detailed description regarding both the planning and the adherence to planning of training will make it difficult identifying the true value of an intervention in a clinical setting (Reimer, 1998).

LTX-patients may attain significant improvement in pulmonary function and exercise capacity; however, peak exercise performance remains often suboptimal. Previous studies that evaluated cardio-pulmonary performance following single- and double-LTX report a reduced anaerobic threshold and reduced maximum oxygen consumption even without apparent significant cardiac or ventilatory limitations in the patients (Williams et al., 1992; Evans et al., 1997; Schwaiblmair et al., 1999). LTX- candidates with advanced lung disease (e.g., COPD), are often severely deconditioned and have reduced skeletal muscle mass and weakness (1999, 1999; Ahya and Kawut, 2005). Weak LTX patients are less likely to favorably respond to PE interventions (Vivodtzev et al., 2011). Seen from this perspective it becomes clear why it is so important to be able and identify replicable successful interventions. The proper description and application of interventions with sufficient details will not only prevent wasteful research from happening but will also potentially increase the impact of research on the health of patients.

In this review specificity, initial values, overload and, progression were the most frequently applied (i.e., explicitly reported) training principles, in 7/7 (specificity & initial values) and 6/7 (overload & progression) of the reviewed studies respectively. In accordance with this reporting, most exercise trials clearly outlined training progression and reported their intervention to be specifically designed to the target population. These aspects warrant reproducibility with respect to these training principles. In contrast to this, however, reversibility values (1/7) and diminishing return (0/7) were only once or not at all considered. This is a point of concern because without knowing the baseline fitness levels of studied participants, it is difficult to generalize the findings to a clinical setting. In clinical settings important reductions in skeletal muscle force immediately after lung transplantation have been mentioned with striking differences in recovery behavior observable between men and women (Maury et al., 2008). Delayed recovery of exercise capacity is, furthermore, secondary to slow recovery of muscle strength in these patients (Walsh et al., 2013). It seems fair to speculate that the mechanisms behind slower recovery rates for women might be better elucidated when information about initial fitness levels would be available and could be compared to sex specific reference values.

Moreover, interpretation of exercise results is hindered due to a lack of reporting exercise frequency (0/7), intensity (4/7) and, Time (1/7). Information about these FITT components of exercise are, however, important since appropriate training parameters in terms of time, frequency, and intensity seem necessary to achieve improvements in limb muscle function and exercise capacity of LTX patients (Langer, 2015).

Current guidelines for pulmonary rehabilitation do not include lung transplant candidates or recipients (Spruit et al., 2013) indicating the existing unclarity related to whether LTX patients can reap benefits from specific rehabilitation or exercise programs. This prompted a multi-disciplinary group of experts in solid organ transplantation; e.g., clinicians, researchers, administrators and patient representatives, to formulate research recommendations in this area (Mathur et al., 2014). The number three place in the top research priorities identified by the group was given to knowledge translation about current evidence together with identified gaps in evidence to relevant stakeholders (Mathur et al., 2014). This is expected to give a boost in addressing future research in exercise for solid organ transplant. Based on the findings of our review the reporting of exercise intervention programs that would allow full replication of the interventions should be added to such an agenda. The reporting of future RCTs evaluating PE interventions in LTX patients may ameliorate when standards of trial reporting (Moher et al., 2001) are already taken into account in the trial planning phase, together with checklists helping in the detailed description of interventions.

Study Limitations

There were some limitations related to this systematic review that should be mentioned. To the best of our knowledge, this systematic review is the first to investigate the replicability of exercise interventions in LTX patients by assessing reporting of exercise training principles. This makes that instead of focusing on the actual intervention outcomes the review rather directs attention on the reporting of intervention content. In our endeavor to achieve a robust systematic review, we developed and documented the methods (e.g., a systematic search strategy and several worksheets for collecting and synthesizing the data) in advance. Due to the number of existing trials on LTX exercise interventions, we decided to focus exclusively on RCTs to ensure high external validity. However, some limitations are a consequence of this approach. Because we restricted our search to English language publications we might have missed out on studies reported in other languages. This gives a possibility that important RCTs published in other languages were missed. Second, because of the scope of the review, we did not perform meta-analyses of RCT results. Therefore, we cannot make any recommendations concerning preferable exercise interventions for LTX patients. However, due to the fact that no guidelines for this patients group currently exists (Spruit et al., 2013) we estimate this limitation not being grave. Currently we cannot refer to credible literature for training recommendations based on best available evidence for LTX patients. Furthermore, a selection bias may have been present, as the database search was performed by a professional librarian up to November 2016, hereafter the databases were checked monthly by RHK and NF up to December 2017.

Conclusions

This review showed that replicability of many exercise interventions in LTX is not warranted due to poor descriptions of important items related to training. In particular there were insufficiently detailed reporting of training principles and FITT components in programs developed for LTX. When training program details are lacking or insufficiently described, translation into clinical practice is left with uncertainties in relation to the effectiveness of the programs. Future interventions that aim to train LTX patients should spent effort in writing reports in which the intervention is detailed to such an extent that full replicability in clinical settings can be guaranteed.

Author Contributions

RK conceived the methodology and carried out quality assessment, data analysis, and manuscript writing. NF participated in methodology conception, data assessment, and analyses and manuscript writing. DK and AM carried out data collection and analysis, and manuscript writing. EdB supervised progress, helped with methodology conception, manuscript writing & critical revision for scientific content. All authors read and approved the final manuscript.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The reviewer RA and handling Editor declared their shared affiliation at time of review.

Acknowledgments

Dr. Martina Gosteli (MG) from the Scientific Library of the University of Zurich is acknowledged for her help in developing and conducting the search strategy of this review.

Abbreviations

BMD, bone mineral density; COPD, Chronic obstructive pulmonary disease, FEV1, Forced expiratory volume in 1 second; FITT, Frequency, Intensity, Time, Type; HIIT, High intensity interval training; LTX, Lung transplantation; PE, Physical exercise; VO2max, Maximum oxygen consumption, VO2peak, Peak power output.

References

Skeletal muscle dysfunction in chronic obstructive pulmonary disease. (1999) A statement of the American Thoracic Society and European Respiratory Society. Am. J. Respir. Crit. Care. Med. 159(4 Pt 2), S1–S40.

Ahya, V. N., and Kawut, S. M. (2005). Noninfectious pulmonary complications after lung transplantation. Clin. Chest Med. 26, 613–622. doi: 10.1016/j.ccm.2005.06.006

PubMed Abstract | CrossRef Full Text

Ammann, B. C., Knols, R. H., Baschung, P., de Bie, R. A., and de Bruin, E. D. (2014). Application of principles of exercise training in sub-acute and chronic stroke survivors: a systematic review. BMC Neurol. 14:167. doi: 10.1186/s12883-014-0167-2

PubMed Abstract | CrossRef Full Text | Google Scholar

Baschung Pfister, P., de Bruin, E. D., Tobler-Ammann, B. C., Maurer, B., and Knols, R. H. (2015). The relevance of applying exercise training principles when designing therapeutic interventions for patients with inflammatory myopathies: a systematic review. Rheumatol. Int. 35, 1641–1654. doi: 10.1007/s00296-015-3343-9

PubMed Abstract | CrossRef Full Text | Google Scholar

Bishop, P. A., Jones, E., and Woods, A. K. (2008). Recovery from training: a brief review: brief review. J. Strength Cond. Res. 22, 1015–1024. doi: 10.1519/JSC.0b013e31816eb518

PubMed Abstract | CrossRef Full Text | Google Scholar

Braith, R. W., Conner, J. A., Fulton, M. N., Lisor, C. F., Casey, D. P., Howe, K. S., et al. (2007). Comparison of alendronate vs alendronate plus mechanical loading as prophylaxis for osteoporosis in lung transplant recipients: a pilot study. J. Heart Lung Transplant. 26, 132–137. doi: 10.1016/j.healun.2006.11.004

PubMed Abstract | CrossRef Full Text | Google Scholar

Campbell, K. L., Neil, S. E., and Winters-Stone, K. M. (2012). Review of exercise studies in breast cancer survivors: attention to principles of exercise training. Br. J. Sports Med. 46, 909–916. doi: 10.1136/bjsports-2010-082719

PubMed Abstract | CrossRef Full Text | Google Scholar

Caspersen, C. J., Powell, K. E., and Christenson, G. M. (1985). Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 100, 126–131.

PubMed Abstract | Google Scholar

Didsbury, M., McGee, R. G., Tong, A., Craig, J. C., Chapman, J. R., Chadban, S., et al. (2013). Exercise training in solid organ transplant recipients: a systematic review and meta-analysis. Transplantation 95, 679–687. doi: 10.1097/TP.0b013e31827a3d3e

PubMed Abstract | CrossRef Full Text | Google Scholar

Downs, S. H., and Black, N. (1998). The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J. Epidemiol. Community Health 52, 377–384. doi: 10.1136/jech.52.6.377

PubMed Abstract | CrossRef Full Text | Google Scholar

Eggenberger, P., Schumacher, V., Angst, M., Theill, N., and de Bruin, E. D. (2015). Does multicomponent physical exercise with simultaneous cognitive training boost cognitive performance in older adults? A 6-month randomized controlled trial with a 1-year follow-up. Clin. Interv. Aging 10, 1335–1349. doi: 10.2147/CIA.S87732

PubMed Abstract | CrossRef Full Text | Google Scholar

Evans, A. B., Al-Himyary, A. J., Hrovat, M. I., Pappagianopoulos, P., Wain, J. C., Ginns, L. C., et al. (1997). Abnormal skeletal muscle oxidative capacity after lung transplantation by 31P-MRS. Am. J. Respir. Crit. Care Med. 155, 615–621. doi: 10.1164/ajrccm.155.2.9032203

PubMed Abstract | CrossRef Full Text | Google Scholar

Field, A. (2014). Discovering Statistics Using IBM SPSS Statistics: and Sex and Drugs and Rock'n'roll, 4th Edn. London: Sage.

Fuller, L. M., Button, B., Tarrant, B., Steward, R., Bennett, L., Snell, G., et al. (2017a). Longer versus shorter duration of supervised rehabilitation after lung transplantation: a randomized trial. Arch. Phys. Med. Rehabil. 98, 220–226.e3. doi: 10.1016/j.apmr.2016.09.113

PubMed Abstract | CrossRef Full Text | Google Scholar

Fuller, L. M., El-Ansary, D., Button, B. M., Corbett, M., Snell, G., Marasco, S., et al. (2017b). Effect of upper limb rehabilitation compared to no upper limb rehabilitation in lung transplant recipients - a randomized controlled trial. Arch. Phys. Med. Rehabil. 99, 1257–1264.e2. doi: 10.1016/j.apmr.2017.09.115

PubMed Abstract | CrossRef Full Text | Google Scholar

Gloeckl, R., Heinzelmann, I., Seeberg, S., Damisch, T., Hitzl, W., and Kenn, K. (2015). Effects of complementary whole-body vibration training in patients after lung transplantation: a randomized, controlled trial. J. Heart Lung Transplant. 34, 1455–1461. doi: 10.1016/j.healun.2015.07.002

PubMed Abstract | CrossRef Full Text | Google Scholar

Hatt, K., Kinback, N. C., Shah, A., Cruz, E., and Altschuler, E. L. (2017). A review of lung transplantation and its implications for the acute inpatient rehabilitation team. PM R 9, 294–305. doi: 10.1016/j.pmrj.2016.09.013

PubMed Abstract | CrossRef Full Text | Google Scholar

Hoffman, J. (2002). Physiological Aspects of Sport Training and Performance: Champaign, IL: Human Kinetics.

Google Scholar

Hoffmann, T. C., Glasziou, P. P., Boutron, I., Milne, R., Perera, R., Moher, D., et al. (2014). Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ 348:g1687. doi: 10.1136/bmj.g1687

PubMed Abstract | CrossRef Full Text | Google Scholar

Ihle, F., Neurohr, C., Huppmann, P., Zimmermann, G., Leuchte, H., Baumgartner, R., et al. (2011). Effect of inpatient rehabilitation on quality of life and exercise capacity in long-term lung transplant survivors: a prospective, randomized study. J Heart Lung Transplant. 30, 912–919. doi: 10.1016/j.healun.2011.02.006

PubMed Abstract | CrossRef Full Text | Google Scholar

Kamper, S. J., Moseley, A. M., Herbert, R. D., Maher, C. G., Elkins, M. R., and Sherrington, C. (2015). 15 years of tracking physiotherapy evidence on PEDro, where are we now? Br. J. Sports Med. 49, 907–909. doi: 10.1136/bjsports-2014-094468

PubMed Abstract | CrossRef Full Text | Google Scholar

Knols, R. H., Vanderhenst, T., Verra, M. L., and de Bruin, E. D. (2016). Exergames for patients in acute care settings: systematic review of the reporting of methodological quality, FITT components, and program intervention details. Games Health J. 5, 224–235. doi: 10.1089/g4h.2015.0067

PubMed Abstract | CrossRef Full Text | Google Scholar

Landis, J. R., and Koch, G. G. (1977). The measurement of observer agreement for categorical data. Biometrics 33, 159–174. doi: 10.2307/2529310

PubMed Abstract | CrossRef Full Text | Google Scholar

Langer, D. (2015). Rehabilitation in patients before and after lung transplantation. Respiration 89, 353–362. doi: 10.1159/000430451

PubMed Abstract | CrossRef Full Text | Google Scholar

Langer, D., Burtin, C., Schepers, L., Ivanova, A., Verleden, G., Decramer, M., et al. (2012). Exercise training after lung transplantation improves participation in daily activity: a randomized controlled trial. Am. J. Transplant.12, 1584–1592. doi: 10.1111/j.1600-6143.2012.04000.x

PubMed Abstract | CrossRef Full Text | Google Scholar

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P., et al. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J. Clin. Epidemiol. 62, e1–e34. doi: 10.1016/j.jclinepi.2009.06.006

PubMed Abstract | CrossRef Full Text

Mathur, S., Janaudis-Ferreira, T., Wickerson, L., Singer, L. G., Patcai, J., Rozenberg, D., et al. (2014). Meeting report: consensus recommendations for a research agenda in exercise in solid organ transplantation. Am. J. Transplant. 14, 2235–2245. doi: 10.1111/ajt.12874

PubMed Abstract | CrossRef Full Text | Google Scholar

Maury, G., Langer, D., Verleden, G., Dupont, L., Gosselink, R., Decramer, M., et al. (2008). Skeletal muscle force and functional exercise tolerance before and after lung transplantation: a cohort study. Am. J. Transplant. 8, 1275–1281. doi: 10.1111/j.1600-6143.2008.02209.x

PubMed Abstract | CrossRef Full Text | Google Scholar

Mitchell, M. J., Baz, M. A., Fulton, M. N., Lisor, C. F., and Braith, R. W. (2003). Resistance training prevents vertebral osteoporosis in lung transplant recipients. Transplantation 76, 557–562. doi: 10.1097/01.TP.0000076471.25132.52

PubMed Abstract | CrossRef Full Text | Google Scholar

Moher, D., Liberati, A., Tetzlaff, J., and Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J. Clin. Epidemiol. 62, 1006–1012. doi: 10.1016/j.jclinepi.2009.06.005

PubMed Abstract | CrossRef Full Text

Moher, D., Schulz, K. F., and Altman, D. G. (2001). The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 357, 1191–1194. doi: 10.1016/S0140-6736(00)04337-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Moseley, A., Costa, L. O. P., and Hegenscheidt, S. (2015). Interrater- und Paralleltest-reliabilität der deutschen version der PEDro-skala. Physioscience 11, 164–170. doi: 10.1055/s-0035-1554029

CrossRef Full Text | Google Scholar

Reimer, D. (1998). Physical Fitness Training. Field Manual No 21., 20.

Schoene, D., Valenzuela, T., Lord, S. R., and de Bruin, E. D. (2014). The effect of interactive cognitive-motor training in reducing fall risk in older people: a systematic review. BMC Geriatr. 14:107. doi: 10.1186/1471-2318-14-107

PubMed Abstract | CrossRef Full Text | Google Scholar

Schulz, K. F., Altman, D. G., and Moher, D. (2010). CONSORT (2010) Statement: updated guidelines for reporting parallel group randomised trials. J. Clin. Epidemiol. 63, 834–840. doi: 10.1016/j.jclinepi.2010.02.005

PubMed Abstract | CrossRef Full Text

Schwaiblmair, M., Reichenspurner, H., Muller, C., Briegel, J., Furst, H., Groh, J., et al. (1999). Cardiopulmonary exercise testing before and after lung and heart-lung transplantation. Am. J. Respir. Crit Care Med. 159, 1277–1283. doi: 10.1164/ajrccm.159.4.9805113

PubMed Abstract | CrossRef Full Text | Google Scholar

Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., et al. (2013). An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am. J. Respir. Crit. Care med. 188, e13–e64. doi: 10.1164/rccm.201309-1634ST

PubMed Abstract | CrossRef Full Text | Google Scholar

Vivodtzev, I., Pison, C., Guerrero, K., Mezin, P., Maclet, E., Borel, J. C., et al. (2011). Benefits of home-based endurance training in lung transplant recipients. Respir. Physiol. Neurobiol. 177, 189–198. doi: 10.1016/j.resp.2011.02.005

PubMed Abstract | CrossRef Full Text | Google Scholar

Wallen, M. P., Skinner, T. L., Pavey, T. G., Hall, A., Macdonald, G. A., and Coombes, J. S. (2016). Safety, adherence and efficacy of exercise training in solid-organ transplant candidates: a systematic review. Transplant. Rev. 30, 218–226. doi: 10.1016/j.trre.2016.07.004

PubMed Abstract | CrossRef Full Text | Google Scholar

Walsh, J. R., Chambers, D. C., Davis, R. J., Morris, N. R., Seale, H. E., Yerkovich, S. T., et al. (2013). Impaired exercise capacity after lung transplantation is related to delayed recovery of muscle strength. Clin Transplant. 27, E504–E511. doi: 10.1111/ctr.12163

PubMed Abstract | CrossRef Full Text | Google Scholar

Wickerson, L., Mathur, S., and Brooks, D. (2010). Exercise training after lung transplantation: a systematic review. J. Heart Lung Transplant. 29, 497–503. doi: 10.1016/j.healun.2009.12.008

PubMed Abstract | CrossRef Full Text | Google Scholar

Wickerson, L., Mathur, S., Singer, L. G., and Brooks, D. (2015). Physical activity levels early after lung transplantation. Phys. Ther. 95, 517–525. doi: 10.2522/ptj.20140173

PubMed Abstract | CrossRef Full Text | Google Scholar

Williams, T. J., Patterson, G. A., McClean, P. A., Zamel, N., and Maurer, J. R. (1992). Maximal exercise testing in single and double lung transplant recipients. Am. Rev. Respir. Dis. 145, 101–105. doi: 10.1164/ajrccm/145.1.101

PubMed Abstract | CrossRef Full Text | Google Scholar

Winters-Stone, K. M., Neil, S. E., and Campbell, K. L. (2014). Attention to principles of exercise training: a review of exercise studies for survivors of cancers other than breast. Br. J. Sports Med. 48, 987–995. doi: 10.1136/bjsports-2012-091732

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: lung transplant, exercise, tidier checklist, adherence, systematic review, methodological

Citation: Knols RH, Fischer N, Kohlbrenner D, Manettas A and de Bruin ED (2018) Replicability of Physical Exercise Interventions in Lung Transplant Recipients; A Systematic Review. Front. Physiol. 9:946. doi: 10.3389/fphys.2018.00946

Received: 11 January 2018; Accepted: 28 June 2018;
Published: 20 July 2018.

Edited by:

Yih-Kuen Jan, University of Illinois at Urbana-Champaign, United States

Reviewed by:

Bruno Balbi, Fondazione Salvatore Maugeri, Veruno (IRCCS), Italy
Ruopeng An, University of Illinois at Urbana-Champaign, United States

Copyright © 2018 Knols, Fischer, Kohlbrenner, Manettas and de Bruin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Eling D. de Bruin, eling.debruin@hest.ethz.ch