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Front. Physiol. | doi: 10.3389/fphys.2018.01236

Semaphorins and their receptors: from axonal guidance to atherosclerosis

  • 1Soochow University, China

Abstract
Semaphorins are a large family of secreted, transmembrane, or GPI-anchored proteins initially identified as axon guidance cues signaling through their receptors, neuropilins and plexins. Emerging evidence suggests that beyond the guidance, they also function in a broad spectrum of pathophysiological conditions, including atherosclerosis, a vascular inflammatory disease. Particular semaphorin members have been demonstrated to participate in atherosclerosis via eliciting endothelial dysfunction, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity and neovascularization. In this review, we focus on the role of those semaphorin family members in the development of atherosclerosis and highlight the mechanistic relevance of semaphorins with atherogenesis.

Keywords: Semaphorins, Atherosclerosis, Inflammation, Cell infiltration, Angiogenesis

Received: 27 May 2018; Accepted: 15 Aug 2018.

Edited by:

Vincenzo Lionetti, Scuola Sant'Anna di Studi Avanzati, Italy

Reviewed by:

Suowen Xu, University of Rochester, United States
Sivareddy Kotla, University of Texas MD Anderson Cancer Center, United States  

Copyright: © 2018 Hu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Shuhong Hu, Soochow University, Suzhou, China, hushuhong19901010@126.com
MD, PhD. Li Zhu, Soochow University, Suzhou, China, zhul@suda.edu.cn