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Front. Physiol. | doi: 10.3389/fphys.2018.01642

Dynamic Cerebral Autoregulation Remains Stable During the Daytime (8 AM to 8 PM) in Healthy Adults

  • 1First Hospital, Jilin University, China
  • 2Shenzhen Institutes of Advanced Technology (CAS), China

Many functions of the human body possess a daily rhythm, disruptions of which often lead to disease. Dynamic cerebral autoregulation (dCA) stabilizes the cerebral blood flow to prompt normal neural function. However, whether dCA is stable across the day remains unknown. This study aimed to investigate the daily rhythm of dCA. Fifty-one healthy adults (38.294 ± 13.279 years, 40 females) were recruited and received six dCA measurements per individual that were conducted at predefined time points: 8:00, 9:00, 11:00, 14:00, 17:00, and 20:00. Although the blood pressure fluctuated significantly, there was no statistical difference in phase difference and gain (autoregulatory parameters) across the six time points. This study demonstrates that dCA remains stable during the interval from 8 AM to 8 PM and underscores the importance of stable dCA in maintaining cerebral blood flow and neural function.

Keywords: Dynamic cerebral autoregulation, Blood pressure (BP), cerebral blood flow (CBF), daily rhythm, Cerebrovascular disease (CVD)

Received: 25 Jul 2018; Accepted: 30 Oct 2018.

Edited by:

Alexey Goltsov, Abertay University, United Kingdom

Reviewed by:

Giovanna Zoccoli, Università degli Studi di Bologna, Italy
Evgeny Zherebtsov, Aston University, United Kingdom  

Copyright: © 2018 Guo, Ma, Liu, Guo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Zhen-Ni Guo, First Hospital, Jilin University, Changchun, Jilin Province, China, zhen1ni2@163.com
Prof. Yi Yang, First Hospital, Jilin University, Changchun, Jilin Province, China, doctoryangyi@163.com