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This article is part of the Research Topic

Arrhythmogenic Substrates in Diabetes and Obesity

Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2018.01670

Mitochondrial dysfunction-associated arrhythmogenic substrates in diabetes mellitus

Jiajia Song1,  Ruilin Yang1,  Jing Yang1 and  Lufang Zhou1*
  • 1University of Alabama at Birmingham, United States

There is increasing evidence that diabetic cardiomyopathy increases the risk of cardiac arrhythmias and sudden cardiac death. While the detailed mechanisms remain incompletely understood, the loss of mitochondrial function, which is often observed in the heart of patients with diabetes, has emerged as a key contributor to the arrhythmogenic substrates. In this mini review, the pathophysiology of mitochondrial dysfunction in diabetes mellitus is explored in detail, followed by descriptions of several mechanisms potentially linking mitochondrial dysfunction to arrhythmogenesis in the context of diabetic cardiomyopathy.

Keywords: Mitochondrial dysfunction, redox signaling, arrhythmogenesis, Diabetes cardiomyopathy, Fibrosis

Received: 24 Aug 2018; Accepted: 07 Nov 2018.

Edited by:

Fadi G. Akar, Icahn School of Medicine at Mount Sinai, United States

Reviewed by:

Tong Liu, Tianjin Medical University, China
Michael A. Colman, University of Leeds, United Kingdom  

Copyright: © 2018 Song, Yang, Yang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Lufang Zhou, University of Alabama at Birmingham, Birmingham, 35294, Alabama, United States, lfzhou@uab.edu