Neural Control of Cardiovascular Function During Exercise in Hypertension
- 1Wayne State University School of Medicine, United States
During dynamic exercise, hypertensive subjects can experience robust increases in arterial pressure and cardiac dysfunction to such an extent that heavy exercise is often not recommended in these patients due to the dangerously high levels of blood pressure sometimes observed. Currently, the mechanisms mediating this cardiovascular dysfunction during dynamic exercise in hypertension are not fully understood. The major reflexes thought to mediate the cardiovascular responses to exercise in normal subjects are central command, arterial baroreflex, and responses to stimulation of skeletal muscle mechano-sensitive and metabo-sensitive afferents. This review will summarize our current understanding of the roles of these reflexes and their interactions in mediating the altered cardiovascular responses to exercise observed in hypertension. We conclude that much work is needed to fully understand the mechanisms mediating excessive pressor response to exercise often seen in hypertensive patients.
Keywords: Hypertension, exercise pressor reflex, Arterial baroreceptor reflex, arterial pressure, Exercice, metaboreflex, mechanoreflex, central command, Baroreflex
Received: 27 Sep 2018;
Accepted: 06 Dec 2018.
Edited by:Antonio Crisafulli, Università degli studi di Cagliari, Italy
Reviewed by:Ferdinando Iellamo, Università degli Studi di Roma Tor Vergata, Italy
Lauro C. Vianna, Universidade de Brasília, Brazil
Konstantina Dipla, Aristotle University of Thessaloniki, Greece
Copyright: © 2018 Dombrowski, Mannozzi and O'Leary. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: PhD. Donal S. O'Leary, Wayne State University School of Medicine, Detroit, United States, firstname.lastname@example.org