Impact Factor 3.394

The world's 3rd most-cited Physiology journal

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2019.00004

DYNAMIC, NOT ISOMETRIC RESISTANCE TRAINING IMPROVES MUSCLE INFLAMMATION, OXIDATIVE STRESS AND HYPERTROPHY IN RATS

 Rodrigo V. Neves1*,  Thiago S. Rosa1,  Michel K. Souza1, 2, Alexsander Oliveira1, Guatavo Gomes1,  Bernardo Brixi1, Luiz Souza1,  Lysleine A. Deus1,  Herbert G. Simões1, Whitney Stone3,  Jonato Prestes1 and  Milton Moraes1
  • 1Universidade Católica de Brasília, Brazil
  • 2Federal University of São Paulo, Brazil
  • 3University of Central Missouri, United States

This study aimed to compare the effects of dynamic (DRT) and isometric (IRT) resistance training on blood glucose, muscle redox capacity, inflammatory state, and muscle strength and hypertrophy. Fifteen 12-week-old male Wistar rats were randomly allocated into 3 groups: control group (CTL), DRT and IRT, n = 5 animals per group. The animals were submitted to a maximal weight carried (MWC; every 15 days) and maximum isometric resistance (MIR; pre- and post-training) tests. Both training protocols were performed 5 times a week during 12 weeks, consisting of 1 set of 8 uninterrupted climbs for 1 min with a 30% overload of MWC. The animals in the IRT group remained under isometry for 1 minute. The DRT group experienced greater MWC from pre to post-training compared to the CTL and IRT groups (p<.0001). The DRT and IRT groups displayed similar gains in MIR (p=.3658). The DRT group exhibited improved glycemic homeostasis (p=.0111), redox (p<.0001), and inflammatory (p<.0001) balance as compared with CTL and IRT groups. In addition, the improved glycemic profile was associated with an increase in muscle strength and hypertrophy, improvement in redox balance and inflammation status. We conclude that DRT was more effective than IRT on increasing cross-sectional area, but not muscle strength, in parallel to improved blood glucose, inflammatory status, and redox balance.

Keywords: Muscle Strength, strength training, static resistance training, Blood Glucose, Inflammation, Cytokines, Antioxidant Defense, Oxidative Stress

Received: 05 Oct 2018; Accepted: 07 Jan 2019.

Edited by:

Kimberly Huey, Drake University, United States

Reviewed by:

Rudy Valentine, Iowa State University, United States
Matthew M. Robinson, Oregon State University, United States  

Copyright: © 2019 Neves, Rosa, Souza, Oliveira, Gomes, Brixi, Souza, Deus, Simões, Stone, Prestes and Moraes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ms. Rodrigo V. Neves, Universidade Católica de Brasília, Brasília, 71966-700, Brazil, rpassosneves@yahoo.com.br