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This article is part of the Research Topic

Skin Functions and Mechanisms

Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2019.00519

Another Reason For Using Caffeine In Dermocosmetics: Sunscreen Adjuvant

 Catarina Rosado1, Viviane K. Tokunaga2, Rafael Sauce2,  Camila Oliveira2, Fernanda Sarruf3,  Roberto Parise-Filho2, Elisabete Maurício1, Tânia Almeida1, Maria Velasco2 and  André R. Baby2*
  • 1CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Portugal
  • 2University of São Paulo, Brazil
  • 3Institute of Integrated Clinical Research (Brazil), Brazil

The excessive exposure to ultraviolet (UV) radiation is the main cause of skin cancer, the most commonly diagnosed cancer in the world. In this context, the development of innovative and more effective sunscreens, with bioactive compounds like caffeine, displaying antioxidant and anticancer potential, is required. This research work assessed in vitro and in vivo the efficacy and safety of topical sunscreen formulations containing caffeine as an adjuvant of the UV filters. Sunscreens were prepared with 2.5% w/w caffeine or in the absence of this compound. In order to evaluate the safety of these formulations, stratum corneum hydration, skin barrier and colorimetry were assessed in vivo in healthy subjects before and after skin treatment with the samples. The efficacy of the sunscreens was assessed in vitro, using PMMA plates and a spectrophotometer equipped with an integrating sphere; and in vivo by the determination of the sun protection factor (SPF). None of the formulations caused erythema or impaired the skin barrier function. The in vitro functional characterization showed higher SPF values for the caffeine formulation. The in vivo studies also confirmed the higher SPF value of the formulation combining caffeine with the filters, compared to the caffeine-free sample. This improvement contributed to an increase of, approximately, 25% in the in vivo anti-UVB protection. In conclusion, caffeine was well tolerated by the skin and increased the photoprotective activity, being a new alternative adjuvant in sunscreens formulation.

Keywords: Caffeine, sunscreen, Sun Protection Factor, UV radiation, cutaneous compatibility

Received: 29 May 2018; Accepted: 11 Apr 2019.

Edited by:

Enzo Berardesca, San Gallicano Hospital, Italy

Reviewed by:

Paola Perugini, University of Pavia, Italy
Ivan D. Da Silva Souza, Independent researcher, Brazil  

Copyright: © 2019 Rosado, Tokunaga, Sauce, Oliveira, Sarruf, Parise-Filho, Maurício, Almeida, Velasco and Baby. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. André R. Baby, University of São Paulo, São Paulo, Brazil, andrerb@usp.br