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Front. Physiol. | doi: 10.3389/fphys.2019.00641

Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans

 Caroline Beaudoin-Chabot1, Lei Wang1, 2, Alexey V. Smarun3, Drasko Vidović3,  Mikhail S. Shchepinov4 and  Guillaume Thibault1*
  • 1School of Biological Sciences, College of Science, Nanyang Technological University, Singapore
  • 2Department of Physiology and Biophysics, Leonard M. Miller School of Medicine, United States
  • 3School of Chemistry, Faculty of Science, Monash University, Australia
  • 4Retrotope Inc., United States

Chemically reinforced essential fatty acids promise to flight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential fatty acids with the isotope deuterium. This substitution leads to stronger chemical bonds and, hence, the prevention of substantial chemical damage. This approach has the advantage of preventing the harmful accumulation of reactive oxygen species (ROS) by inhibiting the propagation of lipid peroxidation while antioxidants potentially neutralise beneficial oxidative species. Here, we developed a model system to mimic the human dietary requirement of omega-3 in C. elegans to study the role of deuterated polyunsaturated fatty acids (D-PUFAs). Deuterated trilinolenin [D-TG(54:9)] was sufficient to prevent the accumulation of lipid peroxides and to reduce the accumulation or ROS. Moreover, D-TG(54:9) significantly extended the lifespan of worms under normal and oxidative stress conditions. These findings suggest that D-PUFAs can be used as a food supplement to decelerate the aging process, resulting in extended lifespan.

Keywords: Polyunsaturated fatty acid (PUFA), Deuterated fatty acids, Oxidative Stress, Lipid peroxidation (LPO), Lifespan - Longevity, C. elegans, Essential fatty acids, Linolenic acid

Received: 10 Mar 2019; Accepted: 06 May 2019.

Edited by:

Mauricio A. Retamal, Universidad del Desarrollo, Chile

Reviewed by:

Manuel Torres, Lipopharma Therapeutics, Spain
Leonardo R. Silveira, Campinas State University, Brazil
Andrey Y. Abramov, Institute of Neurology, Faculty of Brain Sciences, University College London, United Kingdom  

Copyright: © 2019 Beaudoin-Chabot, Wang, Smarun, Vidović, Shchepinov and Thibault. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Guillaume Thibault, School of Biological Sciences, College of Science, Nanyang Technological University, Singapore, 637551, Singapore, thibault@ntu.edu.sg