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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2019.00844

Inflammatory, Oxidative stress, and Angiogenic Growth Factor Responses to Repeated-Sprint Exercise in Hypoxia

 Nobukazu Kasai1, 2, Chihiro Kojima1, 2, Daichi Sumi1, 2, Akiho Ikutomo1 and  Kazushige Goto3*
  • 1College of Sport and Health Science, Ritsumeikan University, Japan
  • 2Japan Society for the Promotion of Science (JSPS), Japan
  • 3Faculty of Sport and Health Science, Ritsumeikan University, Japan

The present study was designed to determine the effects of repeated sprint exercise in moderate hypoxia on inflammatory, muscle damage, oxidative stress, and angiogenic growth factor responses among athletes. Ten male college track and field sprinters [mean ± standard error (SE): age, 20.9 ± 0.1 years; height, 175.7 ± 1.9 cm; body weight, 67.3 ± 2.0 kg] performed two exercise trials in either hypoxia [HYPO; fraction of inspired oxygen (FiO2), 14.5%] or normoxia (NOR; FiO2, 20.9%). The exercise consisted of three sets of 5 × 6-s maximal sprints with 30-s rest periods between sprints and 10 min rest periods between sets. After completing the exercise, subjects remained in the chamber for 3 h under the prescribed oxygen concentration (hypoxia or normoxia). The average power output during exercise did not differ significantly between trials (P = 0.17). Blood lactate concentrations after exercise were significantly higher in the HYPO trial than in the NOR trial (P < 0.05). Plasma interleukin-6 concentrations increased significantly after exercise (P < 0.01), but there was no significant difference between the two trials (P = 0.07). Post-exercise plasma interleukin-1 receptor antagonist, serum myoglobin, serum lipid peroxidation, plasma vascular endothelial growth factor (VEGF), and urine 8-hydroxydeoxyguanosine concentrations did not differ significantly between the two trials (P > 0.05). In conclusion, exercise-induced inflammatory, muscle damage, oxidative stress, and VEGF responses following repeated sprint exercise were not different between hypoxia and normoxia.

Keywords: maximal sprint, Hypoxic exercise, Inflammation, Angiogenic growth factor, Track and field sprinters

Received: 13 Mar 2019; Accepted: 19 Jun 2019.

Edited by:

François Billaut, Laval University, Canada

Reviewed by:

Franck Brocherie, Institut national du sport, de l'expertise et de la performance, France
Raphael Faiss, Centre de recherche et d’expertise des sciences anti-dopage, Faculté des sciences sociales et politiques, Université de Lausanne, Switzerland  

Copyright: © 2019 Kasai, Kojima, Sumi, Ikutomo and Goto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Kazushige Goto, Ritsumeikan University, Faculty of Sport and Health Science, Kyoto, Japan, kagoto@fc.ritsumei.ac.jp