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Front. Physiol. | doi: 10.3389/fphys.2019.01074

Fibro-Adipogenic Progenitors (FAPs) cross-talk in skeletal muscle: the social network

  • 1Fondazione Santa Lucia (IRCCS), Italy
  • 2Sapienza University of Rome, Italy

Skeletal muscle is composed of a large and heterogenous assortment of cell populations that interact with each other to maintain muscle homeostasis and orchestrate regeneration. Although Satellite Cells (SCs) - which are muscle stem cells - are the protagonists of functional muscle repair following damage, several other cells such as inflammatory, vascular and mesenchymal cells coordinate muscle regeneration in a finely tuned process.
Fibro-Adipogenic Progenitors (FAPs) are a muscle interstitial mesenchymal cell population, which supports SCs differentiation during tissue regeneration. During the first days following muscle injury FAPs undergo massive expansion, which is followed by their macrophage-mediated clearance and the re-establishment of their steady state pool. It is during this critical time window that FAPs, together with the other cellular components of the muscle stem cell niche, establish a dynamic network of interactions that culminate in muscle repair. A number of different molecules have been recently identified as important mediators of this cross-talk, and its alteration has been associated with different muscle pathologies. In this review, we will focus on the soluble factors that regulate FAPs activity, highlighting their roles in orchestrating the inter-cellular interactions between FAPs and the other cell populations that participate in muscle regeneration.

Keywords: FAPs, Fibrosis, Cytokine - immunological terms, muscle regeneration, stem cell

Received: 01 Apr 2019; Accepted: 05 Aug 2019.

Edited by:

Dario Coletti, Sapienza University of Rome, Italy

Reviewed by:

John J. McCarthy, University of Kentucky, United States
Bianca Maria Scicchitano, Catholic University of the Sacred Heart, Rome, Italy  

Copyright: © 2019 Madaro, Mozzetta, Biferali and Proietti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Luca Madaro, Fondazione Santa Lucia (IRCCS), Rome, Italy,
Mx. Chiara Mozzetta, Sapienza University of Rome, Rome, 00185, Lazio, Italy,