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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2019.01094

Remote Ischemic Preconditioning has no Short Term Effect on Blood Pressure, Heart Rate and Arterial Stiffness in Healthy Young Adults

 Jan Müller1*, Marius Taebling1 and  Renate M. Oberhoffer1
  • 1Technical University of Munich, Germany

Objective: Remote ischemic preconditioning (RIPC) are short episodes of ischemia and reperfusion applied to remote tissue to trigger responses in a specific organ or cardiovascular bed. This study investigates whether RIPC has a short-term effect on blood pressure (BP), heart rate and arterial stiffness.
Patients and Methods: From March 2018 to August 2018, we included 40 healthy volunteers (23 female, age 25.6 ± 2.8 years) into this single-blinded randomized-controlled crossover trial. After measuring BP, heart rate and arterial stiffness in supine position participants were randomized into intervention or SHAM group. The intervention group then underwent a RIPC protocol (3 cycles of 5 min of 200 mmHg ischemia followed by 5 min reperfusion) at the thigh. The SHAM group followed the same protocol just on the upper arm with 40 mmHg pressure inflation. Directly after this 30-minutes procedure a reassessment of hemodynamic measures was conducted.
Results: There were no significant changes in all five outcome parameters when comparing the effect of RIPC to SHAM. In peripheral systolic BP the mean difference between groups was ∆1.14 ± 6.5 mmHg, (p=.672) and for diastolic BP ∆-0.69 ± 4.5 mmHg (p=.507). Heart rate shoed a ∆-0.8 ± 4.7 beats/min (p=.397). Regarding arterial stiffness measures, there was also no significant improvements thru RIPC. The mean difference between RIPC and SHAM for central systolic BP was ∆0.40 ± 7.2 mmHg (p=.951) and for PWV ∆0.01 ± 0.26 m/s (p=.563).
Conclusions: This study could not find any short-term effects of RIPC on arterial stiffness, BP and heart rate in a RCT in young healthy adults.

Keywords: arterial stiffness, Remote ischemic preconditioning, Arteriosclerosis - diagnosis, Peripheral vascular, intervention

Received: 18 Jun 2019; Accepted: 08 Aug 2019.

Edited by:

John D. Imig, Medical College of Wisconsin, United States

Reviewed by:

Jochen Steppan, Johns Hopkins University, United States
IGNATIOS IKONOMIDIS, National and Kapodistrian University of Athens, Greece  

Copyright: © 2019 Müller, Taebling and Oberhoffer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. Jan Müller, Technical University of Munich, Munich, Germany, j.mueller@tum.de