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Hypothesis and Theory ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2019.01205

Depiction of physiological homeostasis by self-coupled system and its significance

 Xia Lu1, 2, Guantao Jin3,  Wenjin Chen2,  Xinguang Yu1 and Feng Ling2*
  • 1Department of Neurosurgery, Chinese PLA General Hospital and Medical School of Chinese PLA, China
  • 2Department of Neurosurgery, Xuanwu Hospital Capital Medical University and China International Institution of Neuroscience, China
  • 3Advanced School of Art and Humanities, China Academy of Art, China

The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics can be expressed by simple mathematical language. A new disease group was revealed and some useful inferences were obtained through mathematical deduction. They were supported by published studies. SCS-based depiction of homeostasis should be a requisite supplement to medical knowledge systems based on NFS.

Keywords: SCS = self-coupled system, NFS = negative feedback system, Continuous monitoring, WRFID = Weakened regulatory function induced disease, Homeostasis maintenance

Received: 09 Jul 2019; Accepted: 04 Sep 2019.

Copyright: © 2019 Lu, Jin, Chen, Yu and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Feng Ling, Xuanwu Hospital Capital Medical University and China International Institution of Neuroscience, Department of Neurosurgery, Beijing, China,