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Front. Physiol. | doi: 10.3389/fphys.2019.01216

Myo-REG: a portal for signaling interactions in muscle regeneration

 Alessandro Palma1*,  Alberto Calderone1, Andrea Cerquone Perpetuini1,  Federica Ferrentino1,  Claudia Fuoco1,  Cesare Gargioli1,  Giulio Giuliani1, Marta Iannuccelli1, Luana Licata1, Elisa Micarelli1, Serena Paoluzi1, Livia Perfetto1,  Lucia Lisa Petrilli1,  Alessio Reggio1,  Marco Rosina1,  Francesca Sacco1, Simone Vumbaca1, Alessandro Zuccotti1, Luisa Castagnoli1 and  Gianni Cesareni1, 2
  • 1University of Rome Tor Vergata, Italy
  • 2Fondazione Santa Lucia (IRCCS), Italy

Muscle regeneration is a complex process governed by the interplay between several muscle-resident mononuclear cell populations. Following acute or chronic damage these cell populations are activated, communicate via cell-cell interactions and/or paracrine signals, influencing fate decisions via the activation or repression of internal signaling cascades. These are highly dynamic processes, occurring with distinct temporal and spatial kinetics. The main challenge toward a system level description of the muscle regeneration process is the integration of this plethora of inter- and intra-cellular interactions.
We integrated the information on muscle regeneration in a web portal. The scientific content annotated in this portal is organized into two information layers representing relationships between different cell types and intracellular signaling-interactions, respectively. The annotation of the pathways governing the response of each cell type to a variety of stimuli/perturbations occurring during muscle regeneration takes advantage of the information stored in the SIGNOR database. Additional curation efforts have been carried out to increase the coverage of molecular interactions underlying muscle regeneration and to annotate cell-cell interactions.
To facilitate the access to information on cell and molecular interactions in the context of muscle regeneration, we have developed Myo-REG, a web portal that captures and integrates published information on skeletal muscle regeneration.
The muscle-centered resource we provide is one of a kind in the myology field. A friendly interface allows users to explore, approximately 100 cell interactions or to analyze intracellular pathways related to muscle regeneration. Finally, we discuss how data can be extracted from this portal to support in silico modeling experiments.

Keywords: muscle regeneration, cell signaling, cell-cell interaction, pathways, Cell model, web resource, Bioinformatic database

Received: 13 Jun 2019; Accepted: 06 Sep 2019.

Copyright: © 2019 Palma, Calderone, Cerquone Perpetuini, Ferrentino, Fuoco, Gargioli, Giuliani, Iannuccelli, Licata, Micarelli, Paoluzi, Perfetto, Petrilli, Reggio, Rosina, Sacco, Vumbaca, Zuccotti, Castagnoli and Cesareni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mr. Alessandro Palma, University of Rome Tor Vergata, Roma, Italy,