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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Physiol. | doi: 10.3389/fphys.2019.01330

Carotid stiffness assessment with ultrafast ultrasound imaging in case of bicuspid aortic valve

 Guillaume Goudot1*,  Tristan Mirault2, 3, Lina Khider2, 4,  Olivier Pedreira4, Charles Cheng3, Jonathan Porée5, Maxime Gruest4, Xavier Jeunemaitre3, Mathieu Pernot4 and Emmanuel Messas2, 3*
  • 1Institut National de la Santé et de la Recherche Médicale (INSERM), France
  • 2Hôpital Européen Georges-Pompidou (HEGP), France
  • 3INSERM U970 Paris-Centre de Recherche Cardiovasculaire (PARCC), France
  • 4INSERM U1273 Physics for Medicine Paris (ESPCI), France
  • 5Université de Sciences Lettres de Paris, France

Aims: To compare the carotid stiffness and flow parameters by ultrafast ultrasound imaging (UF), in bicuspid aortic valve (BAV) patients to first-degree relatives (controls).

Methods: BAV patients (n=92) and controls (n=48) were consecutively included at a reference center for BAV. Aortic valve and ascending aorta were evaluated by echocardiography. Common carotid arteries were evaluated by UF with a linear probe. A high frame rate (2,000 frames/s) was used to measure the pulse wave velocity (PWV). The arterial diameter change over the cardiac cycle was obtained by UF-Doppler imaging. This allowed us to measure the distensibility and the maximal rate of systolic distension (MRSD). The wall shear stress (WSS) was measured based on the same acquisitions, by analysing blood flow velocities close to the carotid walls.

Results: BAV patients had significantly larger aortic diameters (p<0.001) at the Valsalva sinus and at the tubular ascending aorta but no larger carotid diameters. No significant differences were found in carotid stiffness parameters (distensibility, MRSD and PWV), even though these patients had a higher aortic stiffness. Carotid stiffness correlated linearly with age and similar slopes were obtained for BAV patients and controls. No difference in carotid WSS was found between BAV patients and controls.

Conclusion: Our results clearly show that the carotid stiffness and flow parameters are not altered in case of BAV compared with controls.

Keywords: bicuspid aortic valve, arterial stiffness, ultrafast 2-dimensional imaging, carotid, Wall Shear Stress (WSS)

Received: 19 May 2019; Accepted: 04 Oct 2019.

Copyright: © 2019 Goudot, Mirault, Khider, Pedreira, Cheng, Porée, Gruest, Jeunemaitre, Pernot and Messas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Guillaume Goudot, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France,
Prof. Emmanuel Messas, Hôpital Européen Georges-Pompidou (HEGP), Paris, France,