Articles | Frontiers

Original Research

Published on 23 Aug 2023

Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults

in Ethnopharmacology

Kirsten M. Wright
Melissa Bollen
Jason David
Bridgette Mepham
Armando Alcázar Magaña
Christine McClure
Claudia S. Maier
Joseph F. Quinn
Amala Soumyanath

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1228030

4,949 views
9 citations

Original Research

Published on 13 Jan 2023

Development and validation of two bioanalysis methods for the determination of etimicin in human serum and urine by liquid chromatography-tandem mass spectrometry: Applications to a human pharmacokinetic and breakpoint study

in Pharmacology of Infectious Diseases

Xinge Cui
Xin Zheng
Jianwei Ren
Hongzhong Liu
Yuan Jia
Aiguo Wu
Xiaohong Han

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1076046

3,480 views
4 citations

Review

Published on 06 Dec 2024

Novel and rapid analytical platform development enabled by advances in 3D printing

in Biomedical Analysis and Diagnostics

Alexander S. Malinick
Cole P. Ebel
Daniel D. Stuart
Santino N. Valiulis
Victor A. Hanson
Quan Cheng

Frontiers in Analytical Science

doi 10.3389/frans.2024.1505510

3,234 views
3 citations

Original Research

Published on 27 Jan 2026

A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children

in Metabolomics

Yuan-Yuan Zhang
Jie Wang
Hong-Li Guo
Shi-Yu Wu
Hai-Feng Zhang
Peng-Fei Zheng
Hong-Jun Miao
Feng Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1745458

426 views

Original Research

Published on 23 Jul 2019

Method Validation for Simultaneous Quantification of Olmesartan and Hydrochlorothiazide in Human Plasma Using LC-MS/MS and Its Application Through Bioequivalence Study in Healthy Volunteers

in Translational Pharmacology

Arvind Kumar
Surya Prakash Dwivedi
Tulika Prasad

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00810

9,297 views
21 citations

Original Research

Published on 09 Nov 2023

HPLC for simultaneous quantification of free mannose and glucose concentrations in serum: use in detection of ovarian cancer

in Analytical Chemistry

Yulong Chen
Qin Yao
Lijuan Zhang
Pengjiao Zeng

Frontiers in Chemistry

doi 10.3389/fchem.2023.1289211

6,631 views
12 citations

Perspective

Published on 22 Mar 2022

Secretomics—A Key to a Comprehensive Picture of Unconventional Protein Secretion

in Membrane Traffic and Organelle Dynamics

Gereon Poschmann
Jasmin Bahr
Jürgen Schrader
Ioana Stejerean-Todoran
Ivan Bogeski
Kai Stühler

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2022.878027

9,213 views
18 citations

Original Research

Published on 07 Mar 2019

Development of an Optimized LC-MS Method for the Detection of Specialized Pro-Resolving Mediators in Biological Samples

in Inflammation Pharmacology

Laura Kutzner
Katharina M. Rund
Annika I. Ostermann
Nicole M. Hartung
Jean-Marie Galano
Laurence Balas
Thierry Durand
Michael S. Balzer
Sascha David
Nils Helge Schebb

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00169

17,313 views
98 citations

Original Research

Published on 03 Jan 2022

Development and Validation of a Bioanalytical UHPLC-MS/MS Method Applied to Murine Liver Tissue for the Determination of Indocyanine Green Loaded in H-Ferritin Nanoparticles

in Analytical Chemistry

Cristina Sottani
Elena Grignani
Danilo Cottica
Serena Mazzucchelli
Marta Sevieri
Arianna Chesi
Fabio Corsi
Sarah Galfrè
Francesco Saverio Robustelli della Cuna
Enrica Calleri

Frontiers in Chemistry

doi 10.3389/fchem.2021.784123

4,315 views
6 citations

Original Research

Published on 26 Sep 2024

Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK/ALK inhibitor, in HLMs using fast UPLC–MS/MS method: in silico metabolic lability and DEREK alerts screening

in Analytical Chemistry

Mohamed W. Attwa
Haitham AlRabiah
Ali S. Abdelhameed
Adnan A. Kadi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1323738

1,705 views
1 citation

Original Research

Published on 24 Oct 2024

Pharmacokinetics study of atracurium, dexmedetomidine, midazolam and 1-hydroxymidazolam in patients undergoing acute aortic dissection surgery

in Drug Metabolism and Transport

Huiling Si
Xuanxuan Xu
Yuhao Liang
Shuaibo Shi
Fan Xie
Jie Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427553

1,742 views

Review

Published on 15 Feb 2024

Multiplex electrochemical sensing platforms for the detection of breast cancer biomarkers

in Diagnostic and Therapeutic Devices

Connor O’Brien
Chun Keat Khor
Sina Ardalan
Anna Ignaszak

Frontiers in Medical Technology

doi 10.3389/fmedt.2024.1360510

10,599 views
15 citations

Original Research

Published on 20 Apr 2023

High brightness red emitting polymer beads for immunoassays: Comparison between trifluoroacetylacetonates of Europium

in Inorganic Chemistry

Daniel K. Dinga
Ewa Kasprzycka
Israel P. Assunção
Franziska Winterstein
Amina Alizade
Volkan Caliskanyürek
Dirk Blödorn
Johannes Winkle
Ulrich Kynast
Marina Lezhnina

Frontiers in Chemistry

doi 10.3389/fchem.2023.1179247

4,871 views
5 citations

Original Research

Published on 26 Aug 2022

Pharmacokinetic and pharmacodynamic similarity evaluation between an insulin glargine biosimilar product and Lantus® in healthy subjects: Pharmacokinetic parameters of both parent insulin glargine and M1 were used as endpoints

in Drug Metabolism and Transport

Yiya Wang
Ying Zhou
Juefang Ding
Xianjing Li
Fengxue Guo
Jianfei Zhang
Li Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2022.962201

5,845 views
6 citations

Original Research

Published on 29 Mar 2023

Integrated summary of immunogenicity of polatuzumab vedotin in patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma

in Vaccines and Molecular Therapeutics

Randall C. Dere
Richard L. Beardsley
Dan Lu
Tong Lu
Grace H-W. Ku
Gabriel Man
Van Nguyen
Surinder Kaur

Frontiers in Immunology

doi 10.3389/fimmu.2023.1119510

7,238 views
7 citations

Systematic Review

Published on 22 May 2025

Immunogenicity risk assessment for tailored mitigation and monitoring of biotherapeutics during development: recommendations from the European Immunogenicity Platform

in Vaccines and Molecular Therapeutics

Joanna Grudzinska-Goebel
Karin Benstein
Karien Bloem
Kyra J. Cowan
Boris Gorovits
Maria Jadhav
Melody Janssen
Vibha Jawa
Andrea Kiessling
Daniel Kramer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581153

12,718 views
8 citations

Review

Published on 10 Sep 2024

Reviewing advances in nanophotonic biosensors

in Nanoscience

Zunaira Javaid
Muhammad Aamir Iqbal
Saher Javeed
Siti Sarah Maidin
Kareem Morsy
Ali A. Shati
Jeong Ryeol Choi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1449161

4,572 views
11 citations

Original Research

Published on 29 Sep 2017

Artificial Polysialic Acid Chains as Sialidase-Resistant Molecular-Anchors to Accumulate Particles on Neutrophil Extracellular Traps

in Vaccines and Molecular Therapeutics

Christina E. Galuska
Jan A. Dambon
Andrea Kühnle
Kim F. Bornhöfft
Gerlinde Prem
Kristina Zlatina
Thomas Lütteke
Sebastian P. Galuska

Frontiers in Immunology

doi 10.3389/fimmu.2017.01229

5,655 views
19 citations

Original Research

Published on 04 Dec 2018

A Compartmented Flow Microreactor System for Automated Optimization of Bioprocesses Applying Immobilized Enzymes

in Bioprocess Engineering

Raphael Heinzler
Jonas Hübner
Thomas Fischöder
Lothar Elling
Matthias Franzreb

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2018.00189

5,644 views
15 citations

Original Research

Published on 27 Mar 2025

High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring

in Drug Metabolism and Transport

Jinglong Wang
Junjie Wang
Chenxiao Zhang
Guofei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531496

4,687 views
3 citations

Original Research

Published on 10 Nov 2023

Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development

in Antigen Presenting Cell Biology

M. Violet Lee
Ola M. Saad
Sylvia Wong
Jason LaMar
Lynn Kamen
Ben Ordonia
Rachel Melendez
Azadeh Hassanzadeh
Shan Chung
Surinder Kaur

Frontiers in Immunology

doi 10.3389/fimmu.2023.1295285

7,773 views
13 citations

Original Research

Published on 11 Nov 2024

Immunogenicity assessment strategy for a chemically modified therapeutic protein in clinical development

in B Cell Biology

Charlotte Hagman
Gaetan Chasseigne
Robert Nelson
Florian Anlauff
Mark Kagan
Allison B. Goldfine
Grzegorz Terszowski
Maria Jadhav

Frontiers in Immunology

doi 10.3389/fimmu.2024.1438251

4,528 views
3 citations

Original Research

Published on 01 Jul 2025

Quantitative bead–based multiplex assay for simultaneous determination of IgG concentrations of pertussis toxin, filamentous hemagglutinin, pertactin, diphtheria, tetanus, Haemophilus influenzae b, and hepatitis B in human serum samples

in Vaccines and Molecular Therapeutics

Vishal Rathod
Sagar Katke
Sumant Patil
Sachin Bhandare
Laxmikant Kadam
Manish Gautam
Prabhu Gumma
Krishna Manoj Kumar
Laura Hassall
Cathy Asokanathan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587567

3,568 views
1 citation

Review

Published on 24 Nov 2025

Nonclinical regulatory considerations for investigational new drug applications for regulatory T cell therapies

in Regulatory Science

Phuong-Uyen Dinh
Lauren Mihalcik

Frontiers in Medicine

doi 10.3389/fmed.2025.1626067

1,680 views