CASE REPORT article
Front. Hematol.
Sec. Blood Cancer
Volume 4 - 2025 | doi: 10.3389/frhem.2025.1553336
Successful Management of Acute Promyelocytic Leukemia in the Third Trimester of pregnancy: Case report and Review of Literature
Provisionally accepted
Sirichai Puttirangsan
B PrasertkanchanaNatnipa Parapob
Sirichai Srichairatanakool
Thanawat Rattanathammethee*- Chiang Mai University, Chiang Mai, Thailand
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Acute promyelocyte leukemia (APL) during pregnancy is an exceptionally rare occurrence with high maternal and fetal mortality rate, requiring a highly tailored approach to therapy. We report a case of a patient diagnosed with APL during the third trimester of pregnancy, who initially presented with spontaneous ecchymoses. Treatment was initiated with all-trans retinoic acid (ATRA) and a modified dose of idarubicin, leading to rapid correction of coagulopathy and complete remission of APL. The patient subsequently underwent induced labor, resulting in an uncomplicated vaginal delivery without significant hemorrhage and no evidence of embryopathy in the neonate. To date, no published reports of successful deliveries in patients with APL have been documented in Thailand. This case highlights how a multidisciplinary approach involving obstetricians, hematologists, and neonatologists ensured both maternal survival and optimal neonatal outcomes.
Keywords: Acute promyelocytic leukemia, Pregnancy, Third Trimester, Multidisciplinary approaches, Perinatal Care
Received: 30 Dec 2024; Accepted: 29 May 2025.
Copyright: © 2025 Puttirangsan, Prasertkanchana, Parapob, Srichairatanakool and Rattanathammethee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Thanawat Rattanathammethee, Chiang Mai University, Chiang Mai, Thailand
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