REVIEW article
Front. Hematol.
Sec. Immunobiology and Immunotherapy
Volume 4 - 2025 | doi: 10.3389/frhem.2025.1610794
Advances in Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for HematologicMalignancies and Autoimmune Conditions: A Review of the 2024 American Society of Hematology Annual Meeting
Provisionally accepted
- University of Kansas Medical Center, Kansas City, United States
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Recent advancements in Chimeric Antigen Receptor T cell (CAR T) therapies and manufacturing technologies have expanded treatment options for patients with hematologic malignancies and autoimmune diseases. This review synthesizes the findings from abstracts and oral presentations delivered at the 66th American Society of Hematology (ASH) Annual Meeting. The clinical trial data featured in this review highlights the safety and efficacy of next-generation CAR T constructs, the efficiency of emerging manufacturing technologies, and the expanded indications for CAR T cell therapeutics.
Keywords: Leukemia, oncology, Hematology, Lymphoma, CAR T cancer therapy, Immunotherapy
Received: 14 Apr 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Davis and Lutfi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Samuel Davis, University of Kansas Medical Center, Kansas City, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.