CASE REPORT article
Front. Hematol.
Sec. Blood Cancer
Volume 4 - 2025 | doi: 10.3389/frhem.2025.1655966
Extramedullary Plasmacytoma of the Stomach: A Rare Manifestation of Relapsed Multiple Myeloma
Provisionally accepted
- 1St Mary's General Hospital, Passaic, United States
- 2Saint Michael's Medical Center, Newark, United States
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Extramedullary plasmacytoma (EMP) involving the gastrointestinal (GI) tract is a rare and serious manifestation of multiple myeloma (MM), often indicative of disease relapse and poor prognosis. Case Presentation: We report a case of a 64-year-old female with MM previously treated with cyclophosphamide, bortezomib and dexamethasone (CyBorD) chemotherapy, autologous stem cell transplant, and denosumab, who presented four months post-transplant with melena. Esophagogastroduodenoscopy revealed a submucosal gastric nodule. Histopathology and flow cytometry confirmed monoclonal IgG kappa plasma cell infiltration, consistent with plasmacytoma. Bone marrow biopsy demonstrated remission with less than 3% plasma cells. The patient received local radiotherapy and was started on a daratumumab-based chemotherapy regimen for relapsed MM. Conclusion: Secondary EMP involving the stomach is an exceedingly rare but important differential in MM patients presenting with GI bleeding. This case highlights the need for vigilance in monitoring for extramedullary relapse post-transplant, as early diagnosis and aggressive treatment may impact outcomes.
Keywords: Multiple Myeloma, Extramedullary plasmacytoma, Gastric plasmacytoma, relapse, Autologous stem cell transplant
Received: 29 Jun 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Dirican, Ajayi, Bijoy, Mardini, Shaaban and Guron. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Canan D Dirican, canan.dirican@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.