CASE REPORT article
Front. Hematol.
Sec. Red Cells, Iron and Erythropoiesis
Case Report: Luspatercept for Transfusion-Dependent Anemia of Unknown Etiology
Provisionally accepted
- 1University of Missouri–Kansas City, Kansas City, United States
- 2University of Missouri-Kansas City, Kansas City, United States
- 3Virginia Commonwealth University, Richmond, United States
- 4Saint Luke's Hospital of Kansas City, Kansas City, United States
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Anemia is a common clinical problem with diverse etiologies. Transfusion-dependent anemia (TDA), defined by the need for frequent red blood cell transfusions, can arise from various hematologic disorders. However, in rare instances, despite extensive diagnostic evaluation, the underlying cause may remain elusive. We present a case of a young woman with severe, transfusion-dependent anemia of unknown etiology who failed multiple therapeutic strategies but achieved transfusion independence following treatment with luspatercept. This case highlights the potential for off-label use of luspatercept beyond currently approved indications.
Keywords: Anemia, anemia of unknown etiology, Luspatercept, Tranfusion-dependent anemia, transfusion
Received: 27 Sep 2025; Accepted: 02 Dec 2025.
Copyright: © 2025 Chandra, Bansal, Sharma and Cossor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Simran Chandra
Furha Cossor
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.