ORIGINAL RESEARCH article
Front. Hum. Neurosci.
Sec. Motor Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnhum.2025.1572971
This article is part of the Research TopicFine motor control measurements in neuromotor disordersView all articles
Performance of the Digital Trail Making Test in Older Adults with White Matter Lesions
Provisionally accepted
- 1Baoding First Central Hospital, Baoding, Hebei Province, China
- 2Inner Mongolia Autonomous Region Cancer Hospital, Hohhot, Inner Mongolia Autonomous Region, China
- 3984th Hospital of the People's Liberation Army, Beijing, Beijing Municipality, China
- 4Seventh Medical Center of PLA General Hospital, Beijing, China
- 5Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China
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Background: Studies have reported that the digital assessment technology coupling with traditional trail making test (TMT) can capture additional information around brand-new cognitive domain.The goal of the current study is to exhibit the performance in the digital Trail Making Test (dTMT) in older people with White Matter Lesions (WML).In this single-center, observational study, 18 elderly WML patients admitted to our hospital from June 2021 to June 2022 served as the WML group and 18 participants matched for age, gender, and educational level who were undergoing physical examination in our hospital during the same period served as the control group. The participants completed the dTMTA and dTMTB to obtain the outcomes, including dTMT completion time, number of errors, time inside each circle, total pathway deviation of each step, and velocity of drawing of each step. WML severity were scored according to the Fazekas scale. Multiple neuropsychological assessments were carried out to assess cognitive function. Perdue Pegboard Test (PPT) was used to display the unimanual dexterity (dominant hand task) and fine-motor control (assembly task). The relationships between dTMT variables and cognition and motion in elderly patients with WML were analyzed by linear regression analysis.
Keywords: cognitive dysfunction, fine motor control, white matter lesions, Trail Making Test, small vessel disease
Received: 08 Feb 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Shan, Tian, Zhào, Zhao and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fangyuan Wei, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China
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