ORIGINAL RESEARCH article
Front. Hum. Neurosci.
Sec. Brain Health and Clinical Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnhum.2025.1629366
Influence of Dual Vitamin D Therapy on the Outcome in Patients with Moderate-to-Severe Acute Anterior Circulation Cerebral Infarction and vitamin D insufficiency
Provisionally accepted
- 1Neurology Department, Beibei Hospital of Chongqing Medical University, Chongqing, China
- 2Beibei Hospital of Chongqing Medical University, Chongqing, China
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Objective: To observe whether dual vitamin D supplementation therapy can improve the prognosis of patients with moderate-to-severe anterior circulation acute cerebral infarction accompanied by vitamin D deficiency. Methods: A retrospective analysis was conducted on 36 patients with moderate-to-severe anterior circulation acute cerebral infarction accompanied by vitamin D deficiency. They were divided into a dual vitamin D supplementation therapy group and a control group. The 90-day mRS scores of the two groups of patients and the occurrence of hypercalcemia were compared. Results: The difference in the number of mRS 0-3 cases at 90 days was statistically higher in the dual vitamin D supplementation group than in the control group. (P<0.05). No hypercalcemia was observed in either group. Conclusion: Dual vitamin D supplementation improves outcomes in patients with moderate-to-severe anterior circulation acute cerebral infarction accompanied by vitamin D deficiency, and is relatively safe.
Keywords: Vitamin D, Dual supplementation therapy, Vitamin D Deficiency, Acute cerebralinfarction, prognosis
Received: 15 May 2025; Accepted: 17 Sep 2025.
Copyright: © 2025 Jing, Ying, Chun and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Chen, 364799684@qq.com
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