ORIGINAL RESEARCH article
Front. Hum. Neurosci.
Sec. Brain Health and Clinical Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnhum.2025.1654763
This article is part of the Research TopicAlterations in brain structure and cognitive function caused by cerebrovascular diseases Volume IIView all 3 articles
Risk of Postoperative Major Adverse Cerebrovascular Events in Patients with Spontaneous Intracranial Hematoma Stratified by Type 2 Diabetes Mellitus
Provisionally accepted
- Peking University Third Hospital, Haidian, China
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Diabetes Mellitus (DM) is a common concomitant disease of spontaneous intracranial hemorrhage (ICH). Postoperative major adverse cerebrovascular events (post-MACEs) may diminish the surgical benefits of patients with ICH. However, evidence regarding the impact of DM on post-MACEs remains limited.This was a multicenter cohort study that enrolled ICH patients presenting to eight neurosurgery departments between January 1, 2015, and May 31, 2021. Patients were categorized into DM group and no diabetes mellitus (nDM) group, based on the presence or absence of DM. Intergroup comparisons were performed using chi-square tests for categorical variables and Mann-Whitney U tests for continuous variables. Multivariate logistic regression analysis was conducted to assess the impact of DM on post-MACEs and 30-days mortality after adjusting for confounding factors. A stratified analysis was also conducted based on the type of post-MACEs.A total of 688 ICH patients were included in the study, of whom 576 (83.7%) were classified into the nDM group and 112 (16.3%) into the DM group. Compared with the nDM group, the DM group exhibited significantly higher incidences of overall post-MACEs (28.6%), ischemic post-MACEs (14.3%), hemorrhagic post-MACEs (23.2%), and 30-days mortality (9.8%). After adjusting for potential confounding factors including sex, age, alcohol, coronary heart disease, dyslipidemia, antiplatelet therapy, and intraventricular hemorrhage, DM remained a significant predictor of overall
Keywords: Spontaneous intracranial hematoma 1, Diabetes mellitus 2, surgery 3, Complications 4, Stroke5
Received: 26 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Yang, Wang, Ji, Sun, Feng, Liu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Yang, Peking University Third Hospital, Haidian, China
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