REVIEW article
Front. Hum. Neurosci.
Sec. Brain Health and Clinical Neuroscience
Deep Learning Approaches for EEG-Based Healthcare Applications: A Comprehensive Review
Provisionally accepted
- Geely university, Chengdu, China
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Electroencephalography (EEG) is a longstanding means of non-invasively recording brain signals and has become highly valuable for the study of neurological and cognitive processes. Recent progress in deep learning has also greatly improved both EEG signal analysis and interpretation, making more accurate, reliable and scalable solutions in various healthcare applications. In this review, we present a comprehensive summary of the convergence of EEG and deep learning, with an emphasis on diagnostic of neurological disorders, brain recovery, mental health conditions, and brain-computer interface (BCI) applications. We methodically investigate the application of convolutional neural networks (CNNs), recurrent neural networks (RNNs), long short-term memory (LSTM) models, transformer models and hybrid architectures for EEG-based tasks. Key challenges that have been hampering emerging solutions are critically covered, namely signal-related variability, the lack of data, and deep learning model limited interpretability. Finally, we highlight emerging trends, open issues and promising research directions, with the aim of laying a solid ground towards the improvement of EEG-based healthcare applications and to drive future research in this fast-growing research area.
Keywords: brain–computer interface (BCI), Convolutional neural networks (CNNs), Deep Learning(DL), Electroencephalography (EEG), healthcare, Long short-term memory (LSTM), Multimodal Biosignal Integration, Recurrent neural networks (RNNs)
Received: 20 Aug 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 Lyu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruifang Lyu
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