Effectiveness of Magnetocardiography as A Non-invasive Tool for Functional Assessment of Myocardial Ischemia in Patients with Stable Coronary Artery Disease

Wen-Fei He¹Lihuan Zeng²Nan-Shan Xie³Hao-Xing Liu¹Wen-Min Cui¹Ying Wang¹Zhi-Jian Zhang¹Guan-Lun Ye¹Zhi-Ying Qin¹Zhi-Qiang Guo¹Jun Ma⁴Jianfang Luo^1,5*

• ¹Department of Cardiology,Guangdong Provincial People's Hospital's Nanhai Hospital,the Second People's Hospital of Nanhai District, Foshan, China
• ²Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, China
• ³Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Southern Medical University, Guangzhou, China
• ⁴Raysight Intelligent Medical Technology, Shenzhen, China
• ⁵Department of Cardiology,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University, Guangzhou, China

Background: Identification of coronary ischemia in suspected coronary artery disease (CAD) remains challenging. Magnetocardiography (MCG) demonstrated comparably high diagnostic efficiency for detecting coronary ischemia in previous studies. However, limited evidence exists comparing MCG versus computed tomography angiography-derived fractional flow reserve (CTFFR) in suspected CAD patients.Methods: A total of 291 patients with CTA-confirmed diameter stenosis ranging from 30% to 90% were included and divided into two groups based on the CTFFR values, the stable coronary artery disease (SCAD) group (≤ 0.8) and the non-SCAD group (> 0.8). Magnetic field map (MFM) parameters were employed to construct a diagnostic model. The performance of the models was evaluated using receiver operating characteristic(ROC) curves, accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).Results: Patients with SCAD showed a mean MCG score of 5.6 ± 2.9, while the non-SCAD group demonstrated a mean score of 2.0 ± 1.9 (P < 0.001). The area under the curve (AUC) for ROC analysis was 0.824 (95% CI: 0.772-0.877). Point 5 was selected as the operational cutoff value providing a favorable balance of sensitivity and specificity. Ultimately, MCG score yielded a sensitivity of 69.6%, specificity of 87.9%, PPV of 72.7%, NPV of 86.2%, and accuracy of 82.1%.: Compared to CTFFR, MCG demonstrated superior specificity and moderate sensitivity for de t e c t i n g CAD in patients with diameter stenosis CTA ranging from 30% to 90%. It may provide an alternative to functional evaluation prior to invasive or radiation exposure methods. Keywords：Magnetocardiography (MCG); angiography-derived fractional flow reserve; stable coronary artery disease; coronary ischemia is a challenging issue 删除[无限]: