MINI REVIEW article
Front. Med. Technol.
Sec. Nano-Based Drug Delivery
Volume 7 - 2025 | doi: 10.3389/fmedt.2025.1668738
This article is part of the Research TopicFuture of MedTech: Advances in Nano-Based Drug DeliveryView all articles
Review on extraction technology and function of plant-derived exosome-like nanoparticles
Provisionally accepted
Jiali Cheng
Yi Zhu*- China Agricultural University, Beijing, China
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Plant-derived exosome-like nanoparticles(PELNs) are currently a hot research topic, which have been confirmed to have similar structures and functions to mammalian-derived exosomes. PELNs are lipid bilayer membrane nanovesicles containing bioactive constituents such as miRNA, mRNA, protein, and lipids obtained from plant cells, that can participate in intercellular communication and mediate transboundary communication, have high bioavailability and low immunogenicity, are relatively safe, and have been shown to play an important role in maintaining cell homeostasis and preventing, and treating a variety of diseases. In this review, we describe the biogenesis, isolation and purification methods, structural composition, stability and function of PELNs, mainly introducing the role of PELN in anti-inflammatory, anti-tumor, and drug delivery. Overall, we summarized the importance and challenges of PELNs and provided a theoretical basis for the future research and clinical application of PELNs.
Keywords: plant-derived exosome-like nanoparticles, Isolation, stability, Drug delivery, Challenges
Received: 18 Jul 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Cheng and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Zhu, cjl_serena@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.