MINI REVIEW article
Front. Med. Technol.
Sec. Nano-Based Drug Delivery
Emerging Drug Delivery Approach using Nanomaterials for the Treatment of Endometrial Cancer
Provisionally accepted
Zhuorong Miao1,2Xiaoyan Xiong3Jiahong Gao1,2Yubing Hu1,2Jin Dongdong3Guiyuan Yu1,2Ping Jin1,2*
Wenjun Chen3*- 1Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
- 2Southern Medical University, Guangzhou, China
- 3Harbin Institute of Technology Shenzhen, Shenzhen, China
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Endometrial cancer, accounting for over 90% of uterine malignancies, has experienced a significant global rise in incidence and mortality. Conventional therapies face limitations including fertility compromise, systemic toxicity, drug resistance, and poor outcomes in advanced/recurrent cases. Considering the unique physical and chemical properties of nanomaterials, the emerging drug delivery approaches based on nanomaterials are regarded as a promising pathway for enhanced therapeutic efficiency to combat endometrial cancer. Herein, this mini-review discusses emerging drug delivery approaches to overcome current treatment challenges. We classify common therapeutic nanomaterials into polymer-based nanocarriers, quantum dots, liposomes, and exosomes, analyzing their synthesis, mechanisms, and preclinical efficacy. Finally, scientific challenges and future perspectives for ongoing research in this field are presented.
Keywords: nanomaterials, endometrial cancer, Drug delivery, Nanoplatform, Fertility-preservation treatment
Received: 08 Aug 2025; Accepted: 06 Nov 2025.
Copyright: © 2025 Miao, Xiong, Gao, Hu, Dongdong, Yu, Jin and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ping Jin, pingjin68@smu.edu.cn
Wenjun Chen, chenwenjun@hit.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.