BRIEF RESEARCH REPORT article
Front. Nephrol.
Sec. Critical Care Nephrology
Volume 5 - 2025 | doi: 10.3389/fneph.2025.1583913
Association between lactate dehydrogenase to albumin ratio and ICU mortality in patients with acute kidney injury:a retrospective cohort study
Provisionally accepted
- intensive care unit, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
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Background：Acute kidney injury(AKI) is a prevalent and severe medical condition which is frequently observed in the intensive care unit (ICU). Although numerous biomarkers have been identified to predict the prognosis of AKI, the lactate dehydrogenase to albumin ratio ( LDH/ALB ratio,LAR) has not been extensively investigated. The principal objective of this study is to assess the relationship between LAR and all-cause mortality in patients with AKI.Methods：A total of 6831 AKI patients were included in this study,divided into survival (n= 5152) and non-survival groups (n =1679).The association between LAR and mortality was examined through restricted cubic spline (RCS) analysis and Cox regression analysis.Subgroup analysis was used to search for interactive factors.Additionally, the prognostic capability of LAR was further evaluated using receiver operating characteristic (ROC) curve analysis.Results:The LAR was remarkably higher in the non-survival group (p <0.001).RCS indicated a non-linear correlation between LAR and ICU death (P for non-linearity < 0.001).An LAR of 10.4 was used as the cutoff point to generate the high-LAR and low-LAR subgroups,Kaplan-Meier curves revealed that the ICU cumulative survival rate for patients with AKI was significantly lower in the high-LAR group (Log-rank P < 0.001).The LAR's prediction of ICU mortality in AKI patients yielded an area under the ROC curve of 0.65.Conclusion:Our research suggests LAR monitoring may be promising as a prognostic marker among patients with AKI.Higher LAR is associated with greater ICU mortality.
Keywords: Lactate dehydrogenase, albumin, lactate dehydrogenase to albumin ratio, Acute Kidney Injury, Mortality
Received: 26 Feb 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Gao, Chen, Wu, Xu and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huizhen Chen, intensive care unit, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, China
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