CASE REPORT article
Front. Nephrol.
Sec. Glomerular disease
Volume 5 - 2025 | doi: 10.3389/fneph.2025.1594639
This article is part of the Research TopicRising Stars in Nephrology 2024: Illuminating the Future of Kidney HealthView all 3 articles
IgA nephropathy with crescent cell lesions in human brucellosis patient-a case report
Provisionally accepted
Dongli QI*
Yi Xu*- Shenzhen Second People's Hospital, Shenzhen, China
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Brucellosis is known to impact multiple organ systems in humans, including the urogenital system; however, the occurrence of glomerular diseases is relatively uncommon. In this study, we present the case of a 45-year-old male with no prior history of renal disease, who developed gross hematuria, proteinuria, acute kidney injury, anemia, hypoproteinemia, pleural effusion, arthralgia, and lymphadenopathy following an acute Brucella infection. Renal biopsy revealed mesangial proliferative IgA nephropathy with partial crescents, classified according to the Oxford classification as M1E0S0T0C2, in conjunction with Brucella spondylitis. The patient achieved complete remission after four months of anti-brucellosis therapy with doxycycline, levofloxacin, and rifampicin. In this paper, we present a case study of IgA nephropathy complicated by cellular crescent lesions resulting from acute Brucella infection, which was entirely resolved following anti-Brucella therapy.Additionally, we review previously documented cases of Brucella-associated glomerular disease confirmed through renal biopsy, aiming to offer a reference for clinical diagnosis and treatment.
Keywords: Glomerulonephritis, IgA nephropathy, Brucellosis, Acute Kidney Injury, renal biopsy pathology, Brucella-associated glomerular disease
Received: 16 Mar 2025; Accepted: 28 Jun 2025.
Copyright: © 2025 QI and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dongli QI, Shenzhen Second People's Hospital, Shenzhen, China
Yi Xu, Shenzhen Second People's Hospital, Shenzhen, China
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