SYSTEMATIC REVIEW article
Front. Nephrol.
Sec. Clinical Research in Nephrology
Volume 5 - 2025 | doi: 10.3389/fneph.2025.1617466
Exploring Global Calcimimetics research trends: A Systematic and Thematic Review of Web of Science and Scopus Databases from 1997 to 2024
Provisionally accepted
- 1Libyan International Medical University, Benghazi, Libya
- 2The Chinese University of Hong Kong, Shatin, Hong Kong Region, China
- 3International University of Africa, Khartoum, South Sudan
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Background: Calcimimetics are group of medications increase the sensitivity of the Calcium receptors to extracellular calcium ions and inhibit the release of PTH in chronic kidney disease patients.: The aim of the study was to analyze the global trends in publication of Calcimimetics articles through bibliometric analysis of Web of Science database & Scopus and identify the top most cited articles from 1997 to 2024. Methods A systematic and thematic analysis was made to provide a substantial insight into the Calcimimetics research. Data were analyzed using VOS viewer, Var1.6.6, and the Biblioshiny tool. Results: 3500 documents were identified for analysis. There was an exponential growth in Calcimimetics associated publications (from 57 documents in 2004 to 258 in 2021). The Mean of the Total Citation Per Articles showed decreasing from 226 in 1998 to 0 in 2024. The United States was the most productive country. Goodman W emerged as the most prolific author with high-level of metrics (n = 45, TNC = 4768, and h_index=27). Fukazawa M. was the longest in research activity in the field with published 97 documents in 25 years. "Nephrology Dialysis Transplantation" was the most publishing journal; 112 documents, with h_index of 43. Thematic keyword Plus analysis identified three key domains such as pharmacological targets (CaSR, cinacalcet) reported in Niche themes, and Central CKD-MBD pathways (hemodialysis, vascular calcification, and vitamin D, case reports as reported in emerging/decline themes. The small linkage between 'diabetes' and ' media 'al metabolism' (despite shared CKD complications) suggests a critical research gam. While our thematic map highlights robust research on CKD-MBD pathophysiology, critical clinical outcomes remain underexplored. Future trials should highlight these gaps, particularly in high-risk subgroups like diabetic CKD patients. Conclusion: This review results offer a summary of the global landscape, key research areas, and possible future directions in calcimimetics research. This information can assist researchers in exploring the knowledge structure and understanding future trends in calcimimetics research and supporting collaboration towards advance global research on Calcimimetics.
Keywords: Calcimimetics, CKD, A Systematic and Thematic, Co-citation analysis, thematic mapping analysis
Received: 24 Apr 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Abdelrahman, Musa, Mgbechidinma and Ahmed. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Riad Mohammed Abdelrahman, Libyan International Medical University, Benghazi, Libya
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